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Chemistry

D-Index
43
Citations
7919
World Ranking
17129
National Ranking
4216

Overview

Sriram Krishnaswamy is affiliated with the Children's Hospital of Philadelphia in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with particular focus in subfields such as Hematology, Molecular Biology, Genetics, Organic Chemistry, and Surgery.

Their work addresses key topics including Blood Coagulation and Thrombosis Mechanisms, Hemophilia Treatment and Research, Coagulation, Bradykinin, Polyphosphates, and Angioedema, Cancer-related gene regulation, Platelet Disorders and Treatments, Heparin-Induced Thrombocytopenia and Thrombosis, and Advanced biosensing and bioanalysis techniques.

Notable recent publications by Sriram Krishnaswamy include:

  • FcRn augments induction of tissue factor activity by IgG-containing immune complexes, 2020, Blood
  • Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex, 2020, Journal of Biological Chemistry
  • Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors, 2024, Nature Communications
  • An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa, 2024, Proceedings of the National Academy of Sciences
  • Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples, 2022, Cell chemical biology

Sriram Krishnaswamy frequently collaborates with several co-authors, including Bruce A. Sullenger, Juliana M. Layzer, Haixiang Yu, Shekhar Kumar, and Vladimir N. Kolyadko.

The scientist's publications are often found in journals such as Blood, Research and Practice in Thrombosis and Haemostasis, Journal of Biological Chemistry, Journal of Thrombosis and Haemostasis, and UNC Libraries.

Best Publications

  • Surface-dependent reactions of the vitamin K-dependent enzyme complexes

    KG Mann;ME Nesheim;WR Church;P Haley

  • Cofactor Proteins in the Assembly and Expression of Blood Clotting Enzyme Complexes

    Kenneth G. Mann;Richard J. Jenny;Sriram Krishnaswamy

  • Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.

    Sriram Krishnaswamy;W. R. Church;M. E. Nesheim;K. G. Mann

  • Regulation of Extrinsic Pathway Factor Xa Formation by Tissue Factor Pathway Inhibitor

    Robert J. Baugh;George J. Broze;Sriram Krishnaswamy

  • Surface-dependent hemostasis.

    Mann Kg;Krishnaswamy S;Lawson Jh

  • Prothrombinase complex assembly. Kinetic mechanism of enzyme assembly on phospholipid vesicles.

    Sriram Krishnaswamy;K. C. Jones;K. G. Mann

  • The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction.

    S Krishnaswamy;K G Mann;M E Nesheim

  • Role of the membrane surface in the activation of human coagulation factor X.

    Sriram Krishnaswamy;Kenneth A. Field;Thomas S. Edgington;James H. Morrissey

  • The transition of prothrombin to thrombin

    Sriram Krishnaswamy

  • Exosite-driven substrate specificity and function in coagulation.

    S. Krishnaswamy

  • Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation.

    Sriram Krishnaswamy

  • The binding of factor Va to phospholipid vesicles.

    Sriram Krishnaswamy;Kenneth G. Mann

  • Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13

    Wenjing Cao;Sriram Krishnaswamy;Rodney M. Camire;Peter J. Lenting;Peter J. Lenting

  • New insights into the spatiotemporal localization of prothrombinase in vivo.

    Lacramioara Ivanciu;Sriram Krishnaswamy;Sriram Krishnaswamy;Rodney M. Camire;Rodney M. Camire

  • Zymogen/enzyme discrimination using peptide chloromethyl ketones.

    E. B. Williams;Sriram Krishnaswamy;K. G. Mann

  • The binding of activated protein C to factors V and Va.

    S Krishnaswamy;E B Williams;K G Mann

  • Formation of Factors IXa and Xa by the Extrinsic Pathway DIFFERENTIAL REGULATION BY TISSUE FACTOR PATHWAY INHIBITOR AND ANTITHROMBIN III

    Genmin Lu;George J. Broze;Sriram Krishnaswamy;Sriram Krishnaswamy

  • The interaction of human factor VIIa with tissue factor.

    Sriram Krishnaswamy

  • Regions Remote from the Site of Cleavage Determine Macromolecular Substrate Recognition by the Prothrombinase Complex

    Andreas Betz;Sriram Krishnaswamy

  • Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase.

    Sai K. Buddai;Larisa Toulokhonova;Peter W. Bergum;George P. Vlasuk

Frequent Co-Authors

Kenneth G. Mann
Kenneth G. Mann University of Vermont
Mortimer Poncz
Mortimer Poncz Children's Hospital of Philadelphia
Michael E. Nesheim
Michael E. Nesheim Queen's University
Bruce A. Sullenger
Bruce A. Sullenger Duke University
Wolfram Ruf
Wolfram Ruf Johannes Gutenberg University of Mainz
James A. Huntington
James A. Huntington University of Cambridge
Paul E. Bock
Paul E. Bock Vanderbilt University
Douglas B. Cines
Douglas B. Cines University of Pennsylvania
George P. Vlasuk
George P. Vlasuk Navitor Pharmaceuticals
Peter J. Lenting
Peter J. Lenting University of Paris-Saclay

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