World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
22653
World Ranking
3365
National Ranking
1691

Medicine

D-Index
85
Citations
22938
World Ranking
14735
National Ranking
7454

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Mortimer Poncz is affiliated with the Children's Hospital of Philadelphia in the United States. Their research primarily focuses on hematology within the broader field of medicine, contributing extensively to the understanding of platelet disorders and heparin-induced thrombocytopenia and thrombosis.

The scientist's publications span various topics in hematology, immunology, genetics, surgery, and pulmonary and respiratory medicine. Key research themes include platelet disorders and treatments, blood disorders and treatments, neutrophil and oxidative mechanisms, cell adhesion molecules, blood coagulation and thrombosis mechanisms, and the complement system in diseases.

Among the frequent venues for their research are Blood, bioRxiv (Cold Spring Harbor Laboratory), Research and Practice in Thrombosis and Haemostasis, Blood Advances, and the Journal of Thrombosis and Haemostasis.

Significant recent papers authored or co-authored by Poncz include:

  • Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation, 2020, Blood
  • Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19, 2022, Frontiers in Immunology
  • Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis, 2020, Nature Communications
  • FcRn augments induction of tissue factor activity by IgG-containing immune complexes, 2020, Blood
  • Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes, 2021, Blood

Frequent co-authors include Lubica Rauova, Douglas B. Cines, Gowthami M. Arepally, Amrita Sarkar, and M. Anna Kowalska, reflecting a collaborative network within their field of study.

Poncz has been recognized as a Member of the Association of American Physicians, indicating a professional acknowledgment within the medical research community.

Best Publications

  • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

    W.-J. Song;M. G. Sullivan;R. D. Legare;S. Hutchings

  • Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.

    Charles A. Stanley;Yen K. Lieu;Betty Y.L. Hsu;Alberto B. Burlina

  • Construction of Human Gene Libraries from Small Amounts cf Peripheral Blood: Analysis of β-Like Globin Genes

    M. Poncz;D. Solowiejczyk;B. Harpel;Y. Mory

  • Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

    Ingmar Bruns;Daniel Lucas;Sandra Pinho;Jalal Ahmed

  • Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.

    Kim E. Nichols;John D. Crispino;Mortimer Poncz;James G. White

  • Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

    M Poncz;R Eisman;R Heidenreich;S M Silver

  • Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV.

    Tomasz Rozmyslowicz;Marcin Majka;Jacek Kijowski;Samuel L Murphy

  • Prevalence of Heparin-Associated Antibodies Without Thrombosis in Patients Undergoing Cardiopulmonary Bypass Surgery

    Thomas L. Bauer;Gowthami Arepally;Barbara A. Konkle;Bernadette Mestichelli

  • "Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method

    M Poncz;D Solowiejczyk;M Ballantine;E Schwartz

  • Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

    Lubica Rauova;Li Zhai;M. Anna Kowalska;Gowthami M. Arepally

  • Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.

    Lubica Rauova;Mortimer Poncz;Steven E. McKenzie;Michael P. Reilly

  • Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcγRIIA

    Michael P. Reilly;Scott M. Taylor;Scott M. Taylor;Nealie K. Hartman;Nealie K. Hartman;Gowthami M. Arepally;Gowthami M. Arepally

  • Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia.

    J Amiral;A Marfaing-Koka;M Wolf;MC Alessi

  • Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters.

    Stephanie Pitsilos;Jennifer Hunt;Emile R. Mohler;Anand M. Prabhakar

  • The genomic organization of platelet glycoprotein IIIa.

    A B Zimrin;S Gidwitz;S Lord;E Schwartz

  • Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators.

    Charles A. Stanley;Jie Fang;Karen Kutyna;Betty Y.L. Hsu

  • Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs.

    Jing Yang;Jie Wu;M. Anna Kowalska;Ashutosh Dalvi

  • Organization of the gene for platelet glycoprotein IIb

    Randy Heidenreich;Robin Eisman;Saul Surrey;Kathleen Delgrosso

  • Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

    Xun Wang;John D. Crispino;Danielle L. Letting;Minako Nakazawa

  • Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment

    Helen V. Yarovoi;Dubravka Kufrin;Dubravka Kufrin;Dubravka Kufrin;Don E. Eslin;Don E. Eslin;Don E. Eslin;Michael A. Thornton;Michael A. Thornton;Michael A. Thornton

Frequent Co-Authors

Douglas B. Cines
Douglas B. Cines University of Pennsylvania
Deborah L. French
Deborah L. French Children's Hospital of Philadelphia
Joel S. Bennett
Joel S. Bennett University of Pennsylvania
Saul Surrey
Saul Surrey Thomas Jefferson University
Gerd A. Blobel
Gerd A. Blobel Children's Hospital of Philadelphia
Michael S. Marks
Michael S. Marks Children's Hospital of Philadelphia
Vladimir R. Muzykantov
Vladimir R. Muzykantov University of Pennsylvania
Lawrence F. Brass
Lawrence F. Brass University of Pennsylvania
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Sriram Krishnaswamy
Sriram Krishnaswamy Children's Hospital of Philadelphia

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