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Biology and Biochemistry

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Overview

Lawrence F. Brass is affiliated with the University of Pennsylvania in the United States. Their research primarily falls within the field of Medicine, with a particular focus on subfields including Public Health, Environmental and Occupational Health, Hematology, Gender Studies, Cardiology and Cardiovascular Medicine, and Immunology and Allergy.

The scientist has contributed extensively to topics related to Platelet Disorders and Treatments, Health and Medical Research Impacts, Diversity and Career in Medicine, Innovations in Medical Education, Cell Adhesion Molecules Research, Blood Properties and Coagulation, and Antiplatelet Therapy and Cardiovascular Diseases.

Recent publications by Lawrence F. Brass reflect ongoing research in hematologic and vascular biology. Notable papers include:

  • "Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation," 2020, Proceedings of the National Academy of Sciences
  • "A Human Vascular Injury-on-a-Chip Model of Hemostasis," 2020, Small
  • "RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival," 2020, Blood
  • "GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets," 2020, Blood Advances
  • "Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry," 2020, Research and Practice in Thrombosis and Haemostasis

Frequent co-authors in Lawrence F. Brass's research include Myles H. Akabas, Shuchi Gupta, Timothy J. Stalker, Maurizio Tomaiuolo, and Daniel DeHelian.

Their work appears regularly in several scientific journals, with multiple publications in venues such as:

  • JCI Insight
  • Blood
  • Research and Practice in Thrombosis and Haemostasis
  • Journal of Thrombosis and Haemostasis
  • Proceedings of the National Academy of Sciences

Through these interdisciplinary efforts, Lawrence F. Brass engages with diverse aspects of medicine, addressing biological mechanisms relevant to platelet biology, vascular injury, and related therapeutic strategies within cardiovascular and hematologic contexts.

Best Publications

  • Guidelines for the Early Management of Adults With Ischemic Stroke A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.

    Harold P. Adams;Gregory del Zoppo;Mark J. Alberts;Deepak L. Bhatt

  • Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

    S J Shattil;J A Hoxie;M Cunningham;L F Brass

  • Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

    Marina Molino;Elliot S. Barnathan;Robert Numerof;Jim Clark

  • Thrombin and platelet activation.

    Lawrence F. Brass

  • Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

    Natalie Signoret;Joanne Oldridge;Annegret Pelchen-Matthews;Per J. Klasse

  • Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues.

    Michael R. D'Andrea;Claudia K. Derian;Didier Leturcq;Sherry M. Baker

  • Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

    Timothy J. Stalker;Elizabeth A. Traxler;Jie Wu;Kenneth M. Wannemacher

  • Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.

    R R Vassallo;T Kieber-Emmons;K Cichowski;L F Brass

  • Internalization and recycling of activated thrombin receptors

    James A. Hoxie;Menaka Ahuja;Elizabeth Belmonte;Shelly Pizarro

  • Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

    Peter J. O'Brien;Nicolas Prevost;Marina Molino;M.Katherine Hollinger

  • Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology

    Harold P. Adams;Gregory del Zoppo;Mark J. Alberts;Deepak L. Bhatt

  • Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis.

    Xiaoli Shi;Beena Gangadharan;Lawrence F Brass;Wolfram Ruf

  • Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2

    Donna Woulfe;Hong Jiang;Alicia Morgans;Robert Monks

  • Induction of the fibrinogen receptor on human platelets by intracellular mediators

    S J Shattil;L F Brass

  • Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.

    L. F. Brass;Michael Laposata;H. S. Banga;S. E. Rittenhouse

  • Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions

    Benjamin J. Doranz;Michael J. Orsini;Julie D. Turner;Trevor L. Hoffman

  • Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

    Harjit Singh Banga;Elizabeth R. Simons;Lawrence F. Brass;Susan E. Rittenhouse

  • Protease activated receptors: theme and variations.

    Peter J O'Brien;Marina Molino;Mark Kahn;Lawrence F Brass

  • An RNAi-Based Approach Identifies Molecules Required for Glutamatergic and GABAergic Synapse Development

    Suzanne Paradis;Dana B. Harrar;Dana B. Harrar;Yingxi Lin;Yingxi Lin;Alex C. Koon;Alex C. Koon

  • Endothelial Cell Thrombin Receptors and PAR-2 TWO PROTEASE-ACTIVATED RECEPTORS LOCATED IN A SINGLE CELLULAR ENVIRONMENT

    Marina Molino;Marina Molino;Marilyn J. Woolkalis;John Reavey-Cantwell;Domenico Praticó

Frequent Co-Authors

Scott L. Diamond
Scott L. Diamond University of Pennsylvania
James A. Hoxie
James A. Hoxie University of Pennsylvania
David R. Manning
David R. Manning University of Pennsylvania
Mortimer Poncz
Mortimer Poncz Children's Hospital of Philadelphia
Jie Wu
Jie Wu Temple University
Sanford J. Shattil
Sanford J. Shattil University of California, San Diego
Mark L. Kahn
Mark L. Kahn University of Pennsylvania
John W. Weisel
John W. Weisel University of Pennsylvania
Myles H. Akabas
Myles H. Akabas Albert Einstein College of Medicine
Hitoshi Kikutani
Hitoshi Kikutani Osaka University

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