David R. Manning

Overview

Best Publications

• Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins

  Rolf T. Windh;Menq Jer Lee;Timothy Hla;Songzhu An

  483
  Citations

• Activation of heterotrimeric G proteins by Smoothened

  Natalia A. Riobo;Berangere Saucy;Cherisse DiLizio;David R. Manning

  318
  Citations

• Regulation of G proteins by covalent modification.

  Catherine A Chen;David R Manning

  271
  Citations

• Pathways of signal transduction employed by vertebrate Hedgehogs

  Natalia A. Riobo;David R. Manning

  253
  Citations

• Reconstitution of receptors and GTP-binding regulatory proteins (G Proteins) in Sf9 Cells: a direct evaluation of selectivity in receptor.G protein coupling

  Alastair J. Barr;Lawrence F. Brass;David R. Manning

  247
  Citations

• Receptors coupled to heterotrimeric G proteins of the G12 family.

  Natalia A. Riobo;David R. Manning

  245
  Citations

• Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets.

  K E Carlson;L F Brass;D R Manning

  244
  Citations

• Signaling through G proteins in platelets: to the integrins and beyond.

  Lawrence F Brass;David R Manning;Karen Cichowski;Charles S Abrams

  243
  Citations

• Myosin light chain phosphorylation-dephosphorylation in mammalian skeletal muscle

  D. R. Manning;J. T. Stull

  239
  Citations

• Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells

  Bryan A. Wolf;Andrew M. Wertkin;Y.Camille Jolly;Robert P. Yasuda

  237
  Citations

• Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs.

  Jing Yang;Jie Wu;M. Anna Kowalska;Ashutosh Dalvi

  235
  Citations

• Expression of the Human 5-Hydroxytryptamine1A Receptor in Sf9 Cells RECONSTITUTION OF A COUPLED PHENOTYPE BY CO-EXPRESSION OF MAMMALIAN G PROTEIN SUBUNITS

  Paul Butkerait;Yejia Zheng;Hazem Hallak;Timothy E. Graham

  225
  Citations

• Myosin light chain phosphorylation and phosphorylase a activity in rat extensor digitorum longus muscle

  David R. Manning;James T. Stull

  198
  Citations

• Heterotrimeric Gi Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

  Ariel Héctor Polizio;Pilar Chinchilla;Xiaole Chen;Sangbumn Kim

  191
  Citations

• Signaling through Gi Family Members in Platelets REDUNDANCY AND SPECIFICITY IN THE REGULATION OF ADENYLYL CYCLASE AND OTHER EFFECTORS

  Jing Yang;Jie Wu;Hong Jiang;Richard Mortensen

  190
  Citations

• Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.

  S F Law;D Manning;T Reisine

  189
  Citations

• Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors.

  Sandra Siehler;David R Manning

  184
  Citations

• Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.

  L F Brass;M J Woolkalis;D R Manning

  182
  Citations

• ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation.

  D R Manning;B A Fraser;R A Kahn;A G Gilman

  180
  Citations

• G Proteins : Techniques of Analysis

  David R. Manning

  71
  Citations