D-Index & Metrics Best Publications

Sarah Spiegel

Virginia Commonwealth University
United States

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Biology and Biochemistry D-index 140 Citations 62,246 448 World Ranking 180 National Ranking 133

Best female scientists D-index 140 Citations 62,385 454 World Ranking 138 National Ranking 86

Research.com Recognitions

Awards & Achievements

2023 - Research.com Best Female Scientist Award

2022 - Research.com Best Female Scientist Award

2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is she best known for?

The fields of study Sarah Spiegel is best known for:

Gene
Enzyme
Apoptosis

Sarah Spiegel combines Biochemistry and Molecular biology in her research. Molecular biology and Biochemistry are two areas of study in which Sarah Spiegel engages in interdisciplinary research. Her Cell biology study frequently intersects with other fields, such as Barrier function. Her work on Cell biology expands to the thematically related Barrier function. In her articles, Sarah Spiegel combines various disciplines, including Signal transduction and Phospholipase. Her study deals with a combination of Phospholipase and Signal transduction. Her research combines Growth factor and Receptor. Her research combines Receptor and Growth factor. Sphingosine is frequently linked to Sphingosine-1-phosphate receptor in her study.

Her most cited work include:

Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology (583 citations)
Epithelial transport and barrier function in occludin-deficient mice (280 citations)
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. (259 citations)

What are the main themes of her work throughout her whole career to date

Sphingosine-1-phosphate and Lipid signaling are fields of study that intersect with her Sphingosine study. She merges Lipid signaling with Sphingosine in her study. Sarah Spiegel combines Biochemistry and Cell in her research. As part of her studies on Cell biology, she frequently links adjacent subjects like Signal transduction. Sarah Spiegel undertakes multidisciplinary investigations into Signal transduction and Receptor in her work. Her study in Sphingosine-1-phosphate extends to Receptor with its themes. Sarah Spiegel undertakes multidisciplinary investigations into Gene and Genetics in her work. Sarah Spiegel carries out multidisciplinary research, doing studies in Genetics and Gene. Her study deals with a combination of Virology and Plant virus.

Sarah Spiegel most often published in these fields:

Biochemistry (55.88%)
Cell biology (39.71%)
Receptor (30.88%)

What were the highlights of her more recent work (between 2010-2020)?

Biochemistry (50.00%)
Gene (33.33%)
Cell biology (33.33%)

In recent works Sarah Spiegel was focusing on the following fields of study:

Many of her studies on Biochemistry apply to Protein kinase B as well. Protein kinase B and Signal transduction are two areas of study in which Sarah Spiegel engages in interdisciplinary research. Her Signal transduction study frequently links to other fields, such as Cell biology. Cell biology is frequently linked to Unfolded protein response in her study. She combines Unfolded protein response and Endoplasmic reticulum in her research. In her work, she performs multidisciplinary research in Endoplasmic reticulum and Integral membrane protein. Her study in Membrane extends to Integral membrane protein with its themes. Her study brings together the fields of Membrane contact site and Membrane. As part of her studies on Membrane contact site, Sarah Spiegel often connects relevant subjects like Membrane protein.

Between 2010 and 2020, her most popular works were:

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress (141 citations)
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy (111 citations)
Recognition deficits in mice carrying mutations of genes encoding BLOC-1 subunits pallidin or dysbindin (14 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Sphingosine-1-phosphate: an enigmatic signalling lipid

Sarah Spiegel;Sheldon Milstien.
Nature Reviews Molecular Cell Biology (2003)

2214 Citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.

Olivier Cuvillier;Grisha Pirianov;Burkhard Kleuser;Philip G. Vanek.
Nature (1996)

1797 Citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Yujing Liu;Ryuichi Wada;Tadashi Yamashita;Yide Mi.
Journal of Clinical Investigation (2000)

1329 Citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

Menq Jer Lee;James R. Van Brocklyn;Shobha Thangada;Catherine H. Liu.
Science (1998)

1123 Citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens.

Ana Olivera;Sarah Spiegel.
Nature (1993)

1037 Citations

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

Nitai C. Hait;Jeremy Allegood;Michael Maceyka;Graham M. Strub.
Science (2009)

999 Citations

Sphingosine-1-phosphate signaling and its role in disease

Michael Maceyka;Kuzhuvelil B. Harikumar;Sheldon Milstien;Sarah Spiegel.
Trends in Cell Biology (2012)

878 Citations

Sphingolipid metabolism and cell growth regulation.

Sarah Spiegel;Alfred H. Merrill.
The FASEB Journal (1996)

806 Citations

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Sergio E. Alvarez;Kuzhuvelil B. Harikumar;Nitai C. Hait;Jeremy Allegood.
Nature (2010)

803 Citations

Sphingolipids - The enigmatic lipid class: Biochemistry, physiology and pathophysiology

Merrill Ah;Schmelz Em;Dillehay Dl;Spiegel S.
Toxicology and Applied Pharmacology (1997)

795 Citations

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Frequent Co-Authors

External Links

Personal Website for Sarah Spiegel