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D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
40739
World Ranking
1012
National Ranking
612

Overview

Sheldon Milstien is affiliated with Virginia Commonwealth University in the United States. Their research spans fields including Biochemistry, Genetics and Molecular Biology, and Medicine, with a primary focus on Molecular Biology and related subfields such as Physiology, Endocrine and Autonomic Systems, Epidemiology, and Oncology.

The main topics covered in Milstien's work include:

  • Sphingolipid Metabolism and Signaling
  • Asthma and respiratory diseases
  • Circadian rhythm and melatonin
  • Lysosomal Storage Disorders Research
  • Calcium signaling and nucleotide metabolism
  • Autophagy in Disease and Therapy
  • Cancer Cells and Metastasis

Their published papers cover various aspects of these topics. Notable recent papers include:

  • "Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma," 2020, Journal of Allergy and Clinical Immunology
  • "Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation," 2020, Journal of Biological Chemistry
  • "Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer," 2022, Cancer Research
  • "Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice," 2023, The FASEB Journal
  • "Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking," 2022, Proceedings of the National Academy of Sciences

Frequent collaborators in these endeavors include:

  • Cynthia Weigel
  • Elisa N.D. Palladino
  • Sarah Spiegel
  • Christopher D. Green
  • Briana N. James

Sheldon Milstien's research contributions have been published across respected venues such as the Journal of Allergy and Clinical Immunology, Journal of Biological Chemistry, Cancer Research, The FASEB Journal, and Proceedings of the National Academy of Sciences.

Best Publications

  • Sphingosine-1-phosphate: an enigmatic signalling lipid

    Sarah Spiegel;Sheldon Milstien

  • Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

    Nitai C. Hait;Jeremy Allegood;Michael Maceyka;Graham M. Strub

  • Sphingosine-1-phosphate signaling and its role in disease

    Michael Maceyka;Kuzhuvelil B. Harikumar;Sheldon Milstien;Sarah Spiegel

  • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

    Sergio E. Alvarez;Kuzhuvelil B. Harikumar;Nitai C. Hait;Jeremy Allegood

  • The outs and the ins of sphingosine-1-phosphate in immunity

    Sarah Spiegel;Sheldon Milstien

  • “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

    Kazuaki Takabe;Steven W. Paugh;Sheldon Milstien;Sarah Spiegel

  • Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

    Hong Liu;Masako Sugiura;Victor E. Nava;Lisa C. Edsall

  • Sphingosine 1-phosphate, a key cell signaling molecule.

    Sarah Spiegel;Sheldon Milstien

  • SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

    Michael Maceyka;Heidi Sankala;Nitai C. Hait;Hervé Le Stunff

  • Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.

    Michael Maceyka;Shawn G Payne;Sheldon Milstien;Sarah Spiegel

  • Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

    Sheldon Milstien;Zvonimir Katusic

  • Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

    John P. Hobson;Hans M. Rosenfeldt;Larry S. Barak;Ana Olivera

  • Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.

    Nitai C. Hait;Carole A. Oskeritzian;Steven W. Paugh;Sheldon Milstien

  • Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

    Jie Liang;Masayuki Nagahashi;Eugene Y. Kim;Kuzhuvelil B. Harikumar

  • Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

    Gregory T. Kunkel;Michael Maceyka;Sheldon Milstien;Sarah Spiegel

  • Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor POTENTIAL INVOLVEMENT IN ANGIOGENESIS

    Fang Wang;James R. Van Brocklyn;John P. Hobson;Sharareh Movafagh

  • Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

    Pnina Rosenkranz-Weiss;William C. Sessa;Sheldon Milstien;Seymour Kaufman

  • Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.

    Poulami Mitra;Carole A. Oskeritzian;Shawn G. Payne;Michael A. Beaven

  • Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis

    Hong Liu;Rachelle E. Toman;Rachelle E. Toman;Sravan K. Goparaju;Michael Maceyka

  • Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

    David R. Gude;Sergio E. Alvarez;Steven W. Paugh;Poulami Mitra

Frequent Co-Authors

Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University
Kazuaki Takabe
Kazuaki Takabe Roswell Park Cancer Institute
Seymour Kaufman
Seymour Kaufman National Institutes of Health
Jeremy C. Allegood
Jeremy C. Allegood Virginia Commonwealth University
Melvyn P. Heyes
Melvyn P. Heyes National Institutes of Health
Ana Olivera
Ana Olivera National Institutes of Health
Kuniaki Saito
Kuniaki Saito Fujita Health University
Itaru Endo
Itaru Endo Yokohama City University
John J. Ryan
John J. Ryan Virginia Commonwealth University

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