Susan Pyne

Overview

Best Publications

• Sphingosine 1-phosphate and cancer.

  Nigel J. Pyne;Susan Pyne

  956
  Citations

• Sphingosine 1-phosphate signalling in mammalian cells

  Susan Pyne;Nigel J. Pyne

  919
  Citations

• International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

  Jerold Chun;Edward J. Goetzl;Timothy Hla;Yasuyuki Igarashi

  611
  Citations

• THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

  Stephen P.H. Alexander;Doriano Fabbro;Eamonn Kelly;Alistair Mathie

  315
  Citations

• Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

  Christine Delon;Maria Manifava;Eleanor Wood;Dawn Thompson

  258
  Citations

• FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

  Francesca Tonelli;Keng Gat Lim;Carolyn Loveridge;Jaclyn Long

  249
  Citations

• Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.

  Susan Pyne;Nigel Pyne

  235
  Citations

• High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

  Carol Watson;Jaclyn S. Long;Clare Orange;Claire L. Tannahill

  232
  Citations

• Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

  Forbes Alderton;Soma Rakhit;Kok Choi Kong;Timothy Palmer

  194
  Citations

• Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

  Susan Pyne;David R. Adams;Nigel J. Pyne

  193
  Citations

• Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase

  Ann-Marie Conway;Soma Rakhit;Susan Pyne;Nigel J. Pyne

  175
  Citations

• Sphingosine 1-phosphate signalling in cancer

  Nigel J. Pyne;Francesca Tonelli;Keng Gat Lim;Jaclyn S. Long

  154
  Citations

• Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.

  Susan Pyne;Sue Chin Lee;Jaclyn Long;Nigel J Pyne

  153
  Citations

• Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.

  Susan Pyne;Joanna Chapman;Leslie Steele;Nigel J. Pyne

  152
  Citations

• FTY720 Analogues as Sphingosine Kinase 1 Inhibitors ENZYME INHIBITION KINETICS, ALLOSTERISM, PROTEASOMAL DEGRADATION, AND ACTIN REARRANGEMENT IN MCF-7 BREAST CANCER CELLS

  Keng Gat Lim;Francesca Tonelli;Zaiguo Li;Xuequan Lu

  147
  Citations

• Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

  Nigel J. Pyne;Melissa McNaughton;Stephanie Boomkamp;Neil MacRitchie

  143
  Citations

• Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.

  Soma Rakhit;Susan Pyne;Nigel J. Pyne

  143
  Citations

• Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

  Catherine Waters;Balwinder Sambi;Kok Choi Kong;Dawn Thompson

  142
  Citations

• Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?

  Nigel J Pyne;Susan Pyne

  142
  Citations

• Sphingosine 1-phosphate and cancer.

  Nigel J. Pyne;Ashref El Buri;David Roger Adams;Susan Pyne

  101
  Citations