Her primary areas of investigation include Sphingosine, Cell biology, Sphingosine kinase 1, Sphingosine-1-phosphate and Biochemistry. Her Sphingosine research includes themes of Cancer research and Kinase. Susan Pyne works mostly in the field of Cell biology, limiting it down to concerns involving Platelet-derived growth factor receptor and, occasionally, Receptor tyrosine kinase, Receptor complex and Growth factor receptor.
Her Sphingosine kinase 1 research integrates issues from Endocrinology, Apoptosis, Proteasome, LNCaP and Allosteric regulation. Her work in Sphingosine-1-phosphate tackles topics such as Signal transduction which are related to areas like Estrogen receptor. Her study explores the link between Biochemistry and topics such as Phosphatidic acid that cross with problems in Phosphatase, Lysophosphatidic acid, Diacylglycerol kinase, Phospholipase D and PLCD3.
Susan Pyne mainly focuses on Sphingosine, Cell biology, Sphingosine-1-phosphate, Biochemistry and Sphingosine kinase. Her Sphingosine study incorporates themes from Lipid signaling, Cancer research and Kinase. Her work deals with themes such as Protein structure and Ceramide, which intersect with Kinase.
Her study focuses on the intersection of Cell biology and fields such as Platelet-derived growth factor receptor with connections in the field of Receptor complex and Tyrosine phosphorylation. Her biological study spans a wide range of topics, including Cancer cell, Endocrinology and Dihydroceramide desaturase. Her Sphingosine kinase research is multidisciplinary, incorporating perspectives in Cancer, Pharmacology, Phosphorylation and p38 mitogen-activated protein kinases.
Her primary areas of study are Sphingosine, Sphingosine-1-phosphate, Sphingosine kinase, Kinase and Cell biology. The study incorporates disciplines such as Cancer and Lipid signaling in addition to Sphingosine. Susan Pyne interconnects Dihydroceramide desaturase, Ceramide, G protein-coupled receptor and Pharmacology in the investigation of issues within Sphingosine-1-phosphate.
Her work carried out in the field of Sphingosine kinase brings together such families of science as Cancer research, Cancer cell, Immunology, Phosphorylation and Sphingosine kinase 1. Susan Pyne studies Protein kinase A, a branch of Kinase. Her study in Cell biology is interdisciplinary in nature, drawing from both Amino acid and Protein structure.
Susan Pyne focuses on Sphingosine, Sphingosine kinase, Sphingosine-1-phosphate, Cell biology and Kinase. Her Sphingosine research is within the category of Receptor. Her Sphingosine kinase research is multidisciplinary, incorporating elements of Cancer research, Lipid signaling, Sphingosine kinase 1 and SPHK2.
Her studies in Sphingosine-1-phosphate integrate themes in fields like Endocrinology and G protein-coupled receptor. Susan Pyne combines subjects such as Cancer cell and Sphingosine-1-phosphate receptor with her study of Cell biology. Her Biochemistry research incorporates themes from Prostate cancer and LNCaP.
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Sphingosine 1-phosphate signalling in mammalian cells
Susan Pyne;Nigel J. Pyne.
Biochemical Journal (2000)
Sphingosine 1-phosphate and cancer.
Nigel J. Pyne;Susan Pyne.
Nature Reviews Cancer (2010)
International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature
Jerold Chun;Edward J. Goetzl;Timothy Hla;Yasuyuki Igarashi.
Pharmacological Reviews (2002)
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid
Christine Delon;Maria Manifava;Eleanor Wood;Dawn Thompson.
Journal of Biological Chemistry (2004)
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
Susan Pyne;Nigel Pyne.
Pharmacology & Therapeutics (2000)
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
Francesca Tonelli;Keng Gat Lim;Carolyn Loveridge;Jaclyn Long.
Cellular Signalling (2010)
High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.
Carol Watson;Jaclyn S. Long;Clare Orange;Claire L. Tannahill.
American Journal of Pathology (2010)
Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.
Forbes Alderton;Soma Rakhit;Kok Choi Kong;Timothy Palmer.
Journal of Biological Chemistry (2001)
Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase
Ann-Marie Conway;Soma Rakhit;Susan Pyne;Nigel J. Pyne.
Biochemical Journal (1999)
Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.
Susan Pyne;Joanna Chapman;Leslie Steele;Nigel J. Pyne.
FEBS Journal (1996)
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