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Biology and Biochemistry

D-Index
114
Citations
48977
World Ranking
832
National Ranking
521

Research.com Recognitions

  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Alfred H. Merrill is affiliated with the Georgia Institute of Technology in the United States. Their research activity primarily spans the fields of biochemistry, genetics, and molecular biology, with 17 publications, alongside contributions to medicine and chemistry. Within these broad areas, their subfields of study notably include molecular biology, spectroscopy, physiology, cell biology, and epidemiology.

Research topics central to Merrill's work focus on sphingolipid metabolism and signaling, lysosomal storage disorders, lipid membrane structure and behavior, metabolomics and mass spectrometry studies, advanced proteomics techniques, mass spectrometry techniques, and cellular transport and secretion.

Frequent collaborators in their research include Robert C. Murphy, Donald B. McCormick, Gerhard Liebisch, Eoin Fahy, and Junken Aoki. Merrill has published multiple papers in recognized academic venues related to lipid research and neurobiology among others.

Their recent publications cover a range of topics and include:

  • "Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures" (2020, Journal of Lipid Research)
  • "Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease" (2020, Progress in Neurobiology)
  • "A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate" (2023, Molecular Pharmacology)
  • "Don't Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies" (2025, International Journal of Molecular Sciences)
  • "The bioactive sphingolipid playbook. A primer for the uninitiated as well as sphingolipidologists" (2025, Journal of Lipid Research)

Merrill's work appears in journals such as the Journal of Lipid Research, Progress in Neurobiology, Molecular Pharmacology, International Journal of Molecular Sciences, and Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.

Among professional distinctions, Merrill was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2000.

Best Publications

  • A comprehensive classification system for lipids

    Eoin Fahy;Shankar Subramaniam;H. Alex Brown;Christopher K. Glass

  • LMSD: LIPID MAPS structure database.

    Manish Sud;Eoin Fahy;Dawn Cotter;Alex Brown

  • Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets

    Y A Hannun;C R Loomis;A H Merrill;R M Bell

  • Lipidomics reveals a remarkable diversity of lipids in human plasma

    Oswald Quehenberger;Aaron M. Armando;Alex H. Brown;Stephen B. Milne

  • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme.

    E Wang;W P Norred;C W Bacon;R T Riley

  • Sphingolipid metabolism and cell growth regulation.

    Sarah Spiegel;Alfred H. Merrill

  • Sphingolipids - The enigmatic lipid class: Biochemistry, physiology and pathophysiology

    Merrill Ah;Schmelz Em;Dillehay Dl;Spiegel S

  • Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo: A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize

    Walter F O Marasas;Ronald T. Riley;Katherine A. Hendricks;Victoria L. Stevens

  • Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

    Gerhard Liebisch;Eoin Fahy;Junken Aoki;Edward A. Dennis

  • Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

    Alfred H. Merrill

  • De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.

    Alfred H. Merrill

  • SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

    Michael Maceyka;Heidi Sankala;Nitai C. Hait;Hervé Le Stunff

  • Sphingolipids in Food and the Emerging Importance of Sphingolipids to Nutrition

    Hubert W. Vesper;Eva-Maria Schmelz;Mariana N Nikolova-Karakashian;Dirck L. Dillehay

  • Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry.

    Alfred H. Merrill;M. Cameron Sullards;Jeremy C. Allegood;Samuel Kelly

  • Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

    Nathanael J. Spann;Lana X. Garmire;Jeffrey G. McDonald;David S. Myers

  • Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

    Wenjing Zheng;Jessica Kollmeyer;Holly Symolon;Amin Momin

  • An update of the enzymology and regulation of sphingomyelin metabolism

    Alfred H. Merrill;D.Deborah Jones

  • Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border

    Stacey Ann Missmer;Lucina Suarez;Marilyn Felkner;Elaine Wang

  • Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.

    Elad L. Laviad;Lee Albee;Irene Pankova-Kholmyansky;Sharon Epstein

  • Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.

    A H Merrill;M C Sullards;E Wang;K A Voss

Frequent Co-Authors

Elaine Wang
Elaine Wang Georgia Institute of Technology
Dennis C. Liotta
Dennis C. Liotta Emory University
Jeremy C. Allegood
Jeremy C. Allegood Virginia Commonwealth University
Anthony H. Futerman
Anthony H. Futerman Weizmann Institute of Science
Ronald T. Riley
Ronald T. Riley Agricultural Research Service
Robert C. Murphy
Robert C. Murphy University of Colorado Denver
Shankar Subramaniam
Shankar Subramaniam University of California, San Diego
Edward A. Dennis
Edward A. Dennis University of California, San Diego
David W. Russell
David W. Russell University of Washington
Christopher K. Glass
Christopher K. Glass University of California, San Diego

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