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Biology and Biochemistry

D-Index
78
Citations
16862
World Ranking
4649
National Ranking
2252

Overview

Jacek Bielawski is affiliated with the Medical University of South Carolina in the United States. Their research spans multiple disciplines, primarily within biochemistry, genetics, and molecular biology, with a substantial body of work related to medicine. The focal subfields of study include genetics, molecular biology, oncology, sociology and political science, and public health, environmental and occupational health.

Their research interests cover several main topics, such as evolution and genetic dynamics, gut microbiota and health, inflammatory bowel disease, evolutionary game theory and cooperation, genomics and phylogenetic studies, pancreatic and hepatic oncology research, and plant and animal studies.

Jacek Bielawski has published extensively in various venues, with notable frequent publications in:

  • Journal of Crohn's and Colitis
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cellular and Infection Microbiology
  • Molecular Biology and Evolution

Their recent papers include the following:

  • Bacterial Taxa and Functions Are Predictive of Sustained Remission Following Exclusive Enteral Nutrition in Pediatric Crohn's Disease, 2020, Inflammatory Bowel Diseases
  • Successful Dietary Therapy in Paediatric Crohn's Disease is Associated with Shifts in Bacterial Dysbiosis and Inflammatory Metabotype Towards Healthy Controls, 2022, Journal of Crohn's and Colitis
  • The role of purifying selection in the origin and maintenance of complex function, 2021, Studies in History and Philosophy of Science Part A
  • Re-evaluating the relationship between missing heritability and the microbiome, 2020, Microbiome
  • Antibiotic and antifungal use in pediatric leukemia and lymphoma patients are associated with increasing opportunistic pathogens and decreasing bacteria responsible for activities that enhance colonic defense, 2022, Frontiers in Cellular and Infection Microbiology

The scientist collaborates frequently with other researchers. Their most frequent co-authors include:

  • Katherine A. Dunn
  • Johan Van Limbergen
  • Edward Susko
  • Morgan G. I. Langille
  • Tamara MacDonald

The body of work by Jacek Bielawski reflects a multidisciplinary approach, integrating genetics and molecular biology with medical research focused on diseases such as Crohn's disease, leukemia, and lymphoma. Their publications address evolutionary dynamics, microbial health influences, and complex biological functions, contributing to both theoretical and clinical scientific knowledge.

Best Publications

  • Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

    Jacek Bielawski;Zdzislaw M. Szulc;Yusuf A. Hannun;Alicja Bielawska

  • Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

    R David Sentelle;Can E Senkal;Wenhui Jiang;Suriyan Ponnusamy

  • Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

    Giovanni D’Angelo;Elena Polishchuk;Giuseppe Di Tullio;Michele Santoro

  • Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

    Guang Yang;Leylla Badeanlou;Jacek Bielawski;Amanda J Roberts

  • The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α

    Benjamin J. Pettus;Jacek Bielawski;Anna M. Porcelli;Davis L. Reames

  • Blood sphingolipidomics in healthy humans: impact of sample collection methodology.

    Samar M. Hammad;Jason S. Pierce;Farzan Soodavar;Kent J. Smith

  • Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.

    Fahumiya Samad;Kelly D. Hester;Guang Yang;Yusuf A. Hannun

  • Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

    Sahar A. Saddoughi;Salih Gencer;Yuri K. Peterson;Katherine E. Ward

  • Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas *

    Serap Koybasi;Can E. Senkal;Kamala Sundararaj;Stefka Spassieva

  • Sphingosine kinase 1 is up-regulated in colon carcinogenesis.

    Toshihiko Kawamori;Walid Osta;Korey R. Johnson;Benjamin J. Pettus

  • Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells

    Yusuf Baran;Arelis Salas;Can E. Senkal;Ufuk Gunduz

  • Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α

    Yosuke Osawa;Hiroshi Uchinami;Jacek Bielawski;Robert F. Schwabe

  • PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

    Paolo Neviani;Jason G. Harb;Joshua J. Oaks;Ramasamy Santhanam

  • Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.

    Lihua Shi;Jacek Bielawski;Jinye Mu;Haili Dong

  • Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells

    Jacqueline M. Kraveka;Li Li;Zdzislaw M. Szulc;Jacek Bielawski

  • The human FA2H gene encodes a fatty acid 2-hydroxylase.

    Nathan L. Alderson;Barbara M. Rembiesa;Michael D. Walla;Alicja Bielawska

  • Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.

    Jacek Bielawski;Jason S Pierce;Justin Snider;Barbara Rembiesa

  • Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells

    Norma Marchesini;Walid Osta;Jacek Bielawski;Chiara Luberto

  • Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C18-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

    Serdar Karahatay;Kesha Thomas;Serap Koybasi;Can E. Senkal

  • Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

    Charmi Shah;Guang Yang;Ian Lee;Jacek Bielawski

Frequent Co-Authors

Lina M. Obeid
Lina M. Obeid Stony Brook University
Yusuf A. Hannun
Yusuf A. Hannun Stony Brook University
Alicja Bielawska
Alicja Bielawska Medical University of South Carolina
Besim Ogretmen
Besim Ogretmen Medical University of South Carolina
Adi L. Tarca
Adi L. Tarca National Institutes of Health
Kebin Liu
Kebin Liu Augusta University
S. Michal Jazwinski
S. Michal Jazwinski Tulane University
Kentaro Hanada
Kentaro Hanada National Institutes of Health
Mark S. Kindy
Mark S. Kindy University of South Florida

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