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Biology and Biochemistry

D-Index
69
Citations
14913
World Ranking
7504
National Ranking
3414

Overview

Kentaro Hanada is affiliated with the National Institutes of Health in the United States and has made contributions primarily within the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans several subfields, including Molecular Biology, Cell Biology, Infectious Diseases, Epidemiology, and Hepatology.

The scientist's work focuses on topics related to cellular processes and lipid biology, emphasizing cellular transport and secretion, sphingolipid metabolism and signaling, and lipid membrane structure and behavior. Other areas of investigation include endoplasmic reticulum stress and disease mechanisms, hepatitis C virus research, HIV research and treatment, and viral infections and vectors.

Kentaro Hanada has published in several scientific venues, with notable frequent publications in:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Journal of Clinical Investigation
  • Frontiers in Genetics

Significant recent papers authored or co-authored by Kentaro Hanada include:

  • "Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3" (2021, The EMBO Journal)
  • "Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines" (2020, Frontiers in Genetics)
  • "CERT1 mutations perturb human development by disrupting sphingolipid homeostasis" (2023, Journal of Clinical Investigation)
  • "Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication Factories" (2020, Journal of Virology)
  • "Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus" (2020, Journal of Infection and Chemotherapy)

Collaboration is a significant aspect of their research, with frequent co-authors including Toshiyuki Yamaji, Masayoshi Fukasawa, Shota Sakai, Kyoko Saito, and Yuko Okemoto-Nakamura. These partnerships have contributed to advancing understanding in their fields of study.

Best Publications

  • Molecular machinery for non-vesicular trafficking of ceramide

    Kentaro Hanada;Keigo Kumagai;Satoshi Yasuda;Yukiko Miura

  • Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism.

    Kentaro Hanada

  • Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.

    Miyuki Kawano;Keigo Kumagai;Masahiro Nishijima;Kentaro Hanada

  • CERT Mediates Intermembrane Transfer of Various Molecular Species of Ceramides

    Keigo Kumagai;Satoshi Yasuda;Kazuo Okemoto;Masahiro Nishijima

  • Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft‐mediated CD44–IpaB interaction

    Frank Lafont;Guy Tran Van Nhieu;Kentaro Hanada;Philippe Sansonetti

  • Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes.

    Kentaro Hanada;Masahiro Nishijima;Yuzuru Akamatsu;Richard E. Pagano

  • Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

    Norio Kudo;Keigo Kumagai;Nario Tomishige;Toshiyuki Yamaji

  • The Genome Landscape of the African Green Monkey Kidney-Derived Vero Cell Line

    Naoki Osada;Arihiro Kohara;Toshiyuki Yamaji;Noriko Hirayama

  • Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

    Hideki Aizaki;Kenichi Morikawa;Masayoshi Fukasawa;Hiromichi Hara

  • Mammalian Cell Mutants Resistant to a Sphingomyelin-directed Cytolysin: GENETIC AND BIOCHEMICAL EVIDENCE FOR COMPLEX FORMATION OF THE LCB1 PROTEIN WITH THE LCB2 PROTEIN FOR SERINE PALMITOYLTRANSFERASE

    Kentaro Hanada;Tomoko Hara;Masayoshi Fukasawa;Akiko Yamaji

  • Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.

    Lihua Shi;Jacek Bielawski;Jinye Mu;Haili Dong

  • Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles.

    Isei Tanida;Masayoshi Fukasawa;Takashi Ueno;Eiki Kominami

  • Genetic Evidence for ATP-dependent Endoplasmic Reticulum-to-Golgi Apparatus Trafficking of Ceramide for Sphingomyelin Synthesis in Chinese Hamster Ovary Cells

    Masayoshi Fukasawa;Masahiro Nishijima;Kentaro Hanada

  • Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

    Cherilyn A. Elwell;Shaobo Jiang;Jung Hwa Kim;Albert Lee

  • GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment

    Samit Chatterjee;Elizabeth R. Smith;Kentaro Hanada;Victoria L. Stevens

  • Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids.

    K Hanada;M Nishijima;M Kiso;A Hasegawa

  • A Mammalian Homolog of the Yeast LCB1 Encodes a Component of Serine Palmitoyltransferase, the Enzyme Catalyzing the First Step in Sphingolipid Synthesis

    Kentaro Hanada;Tomoko Hara;Masahiro Nishijima;Osamu Kuge

  • A Novel Inhibitor of Ceramide Trafficking from the Endoplasmic Reticulum to the Site of Sphingomyelin Synthesis

    Satoshi Yasuda;Hidetoshi Kitagawa;Masaharu Ueno;Haruro Ishitani

  • Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements.

    Zhi-Jie Cheng;Raman Deep Singh;Deepak K. Sharma;Eileen L. Holicky

  • Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.

    S Hernández-Tiedra;G Fabriàs;D Davila;Íj Salanueva

Frequent Co-Authors

Masahiro Nishijima
Masahiro Nishijima Showa Pharmaceutical University
Takaji Wakita
Takaji Wakita National Institute of Infectious Diseases
Shu Kobayashi
Shu Kobayashi University of Tokyo
Isei Tanida
Isei Tanida Juntendo University
Tetsuro Suzuki
Tetsuro Suzuki Hamamatsu University
Toshihiro Horii
Toshihiro Horii Osaka University
Kazumitsu Ueda
Kazumitsu Ueda Kyoto University
Jacek Bielawski
Jacek Bielawski Medical University of South Carolina
Makoto Kuroda
Makoto Kuroda National Institutes of Health

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