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Joost C. M. Holthuis

Joost C. M. Holthuis

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
9308
World Ranking
17990
National Ranking
1237

Overview

Joost C. M. Holthuis is affiliated with Osnabrück University in Germany and specializes in biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, physiology, and cell biology, with contributions also in epidemiology and clinical biochemistry.

Their main research topics include sphingolipid metabolism and signaling, lipid membrane structure and behavior, erythrocyte function and pathophysiology, cellular transport and secretion, mitochondrial function and pathology, autophagy in disease and therapy, and ATP synthase and ATPases research.

Holthuis has published extensively, contributing notably to the following papers:

  • Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair, 2022, Nature Communications
  • Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase, 2023, Nature Communications
  • Membrane damage and repair: a thin line between life and death, 2023, Biological Chemistry
  • Short Photoswitchable Ceramides Enable Optical Control of Apoptosis, 2021, ACS Chemical Biology
  • Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway, 2022, eLife

Frequent co-authors in Holthuis's research include Matthijs Kol, Tolulope Sokoya, Jacob Piehler, Patrick Niekamp, and Angelika Hilderink.

Their work has been published predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The FASEB Journal
  • Small
  • Journal of Lipid Research

Best Publications

  • Lipid landscapes and pipelines in membrane homeostasis

    Joost C.M. Holthuis;Anant K. Menon

  • Identification of a family of animal sphingomyelin synthases

    Klazien Huitema;Joep van den Dikkenberg;Jos F H M Brouwers;Joost C M Holthuis

  • Lipid traffic: floppy drives and a superhighway

    Joost C. M. Holthuis;Tim P. Levine

  • Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.

    Thomas Pomorski;Thomas Pomorski;Ruben Lombardi;Howard Riezman;Philippe F. Devaux

  • The organizing potential of sphingolipids in intracellular membrane transport

    Joost C. M. Holthuis;Thomas Pomorski;René J. Raggers;Hein Sprong

  • The Multigenic Sphingomyelin Synthase Family

    Fikadu Geta Tafesse;Philipp Ternes;Joost C.M. Holthuis

  • Two syntaxin homologues in the TGN/endosomal system of yeast

    Joost C.M. Holthuis;Benjamin J. Nichols;Sadhana Dhruvakumar;Hugh R.B. Pelham

  • Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells

    Fikadu Geta Tafesse;Klazien Huitema;Martin Hermansson;Seleéne van der Poel

  • Tracking down lipid flippases and their biological functions

    Thomas Pomorski;Joost C. M. Holthuis;Andreas Herrmann;Gerrit van Meer

  • Sphingolipid transport in eukaryotic cells.

    G. van Meer;J.C.M. Holthuis

  • Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

    Ana M. Vacaru;Fikadu G. Tafesse;Philipp Ternes;Vangelis Kondylis

  • Ceramides bind VDAC2 to trigger mitochondrial apoptosis

    Shashank Dadsena;Svenja Bockelmann;John G M Mina;John G M Mina;Dina G Hassan;Dina G Hassan

  • Loss of P4 ATPases Drs2p and Dnf3p Disrupts Aminophospholipid Transport and Asymmetry in Yeast Post-Golgi Secretory Vesicles

    Nele Alder-Baerens;Quirine Lisman;Lambert Luong;Thomas Pomorski

  • CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery

    Susanne Bryde;Hanka Hennrich;Patricia M. Verhulst;Philippe F. Devaux

  • Lipid traffic: the ABC of transbilayer movement

    R.J. Raggers;T. Pomorski;J.C.M. Holthuis;N. Kälin

  • Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

    Guillaume Lenoir;Patrick Williamson;Catheleyne F. Puts;Joost C.M. Holthuis

  • The syntaxin Tlg1p mediates trafficking of chitin synthase III to polarized growth sites in yeast.

    Joost C. M. Holthuis;Benjamin J. Nichols;Hugh R. B. Pelham

  • Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review).

    Joost C. M. Holthuis;Gerrit van Meer;Klazien Huitema

  • In Vivo Profiling and Visualization of Cellular Protein–Lipid Interactions Using Bifunctional Fatty Acids

    Per Haberkant;Reinout Raijmakers;Marjolein Wildwater;Timo Sachsenheimer

  • Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D

    Joost Holthuis;Thomas A. Owen;Andre J. van Wijnen;Kenneth L. Wright

Frequent Co-Authors

Thomas Günther Pomorski
Thomas Günther Pomorski Ruhr University Bochum
Gerard J. M. Martens
Gerard J. M. Martens Radboud University
Pentti Somerharju
Pentti Somerharju University of Helsinki
Gary S. Stein
Gary S. Stein University of Vermont
Thomas A. Owen
Thomas A. Owen Pfizer (United States)
Patrick Williamson
Patrick Williamson Amherst College
Jane B. Lian
Jane B. Lian University of Vermont
Hugh R.B. Pelham
Hugh R.B. Pelham MRC Laboratory of Molecular Biology
Janet L. Stein
Janet L. Stein University of Vermont
Leo W. J. Klomp
Leo W. J. Klomp Utrecht University

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