World's Best Scientists 2026 revealed!
Joost C. M. Holthuis

Joost C. M. Holthuis

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
9308
World Ranking
17990
National Ranking
1237

Joost C. M. Holthuis publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Joost C. M. Holthuis sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 101 publications — 5th percentile

5% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Joost C. M. Holthuis D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Joost C. M. Holthuis sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 49 D-Index — 9th percentile

9% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Joost C. M. Holthuis is affiliated with Osnabrück University in Germany and specializes in biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, physiology, and cell biology, with contributions also in epidemiology and clinical biochemistry.

Their main research topics include sphingolipid metabolism and signaling, lipid membrane structure and behavior, erythrocyte function and pathophysiology, cellular transport and secretion, mitochondrial function and pathology, autophagy in disease and therapy, and ATP synthase and ATPases research.

Holthuis has published extensively, contributing notably to the following papers:

  • Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair, 2022, Nature Communications
  • Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase, 2023, Nature Communications
  • Membrane damage and repair: a thin line between life and death, 2023, Biological Chemistry
  • Short Photoswitchable Ceramides Enable Optical Control of Apoptosis, 2021, ACS Chemical Biology
  • Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway, 2022, eLife

Frequent co-authors in Holthuis's research include Matthijs Kol, Tolulope Sokoya, Jacob Piehler, Patrick Niekamp, and Angelika Hilderink.

Their work has been published predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The FASEB Journal
  • Small
  • Journal of Lipid Research

Best Publications

  • Lipid landscapes and pipelines in membrane homeostasis

    Joost C.M. Holthuis;Anant K. Menon

  • Identification of a family of animal sphingomyelin synthases

    Klazien Huitema;Joep van den Dikkenberg;Jos F H M Brouwers;Joost C M Holthuis

  • Lipid traffic: floppy drives and a superhighway

    Joost C. M. Holthuis;Tim P. Levine

  • Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.

    Thomas Pomorski;Thomas Pomorski;Ruben Lombardi;Howard Riezman;Philippe F. Devaux

  • The organizing potential of sphingolipids in intracellular membrane transport

    Joost C. M. Holthuis;Thomas Pomorski;René J. Raggers;Hein Sprong

  • The Multigenic Sphingomyelin Synthase Family

    Fikadu Geta Tafesse;Philipp Ternes;Joost C.M. Holthuis

  • Two syntaxin homologues in the TGN/endosomal system of yeast

    Joost C.M. Holthuis;Benjamin J. Nichols;Sadhana Dhruvakumar;Hugh R.B. Pelham

  • Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells

    Fikadu Geta Tafesse;Klazien Huitema;Martin Hermansson;Seleéne van der Poel

  • Tracking down lipid flippases and their biological functions

    Thomas Pomorski;Joost C. M. Holthuis;Andreas Herrmann;Gerrit van Meer

  • Sphingolipid transport in eukaryotic cells.

    G. van Meer;J.C.M. Holthuis

  • Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

    Ana M. Vacaru;Fikadu G. Tafesse;Philipp Ternes;Vangelis Kondylis

  • Ceramides bind VDAC2 to trigger mitochondrial apoptosis

    Shashank Dadsena;Svenja Bockelmann;John G M Mina;John G M Mina;Dina G Hassan;Dina G Hassan

  • Loss of P4 ATPases Drs2p and Dnf3p Disrupts Aminophospholipid Transport and Asymmetry in Yeast Post-Golgi Secretory Vesicles

    Nele Alder-Baerens;Quirine Lisman;Lambert Luong;Thomas Pomorski

  • CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery

    Susanne Bryde;Hanka Hennrich;Patricia M. Verhulst;Philippe F. Devaux

  • Lipid traffic: the ABC of transbilayer movement

    R.J. Raggers;T. Pomorski;J.C.M. Holthuis;N. Kälin

  • Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

    Guillaume Lenoir;Patrick Williamson;Catheleyne F. Puts;Joost C.M. Holthuis

  • The syntaxin Tlg1p mediates trafficking of chitin synthase III to polarized growth sites in yeast.

    Joost C. M. Holthuis;Benjamin J. Nichols;Hugh R. B. Pelham

  • Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review).

    Joost C. M. Holthuis;Gerrit van Meer;Klazien Huitema

  • In Vivo Profiling and Visualization of Cellular Protein–Lipid Interactions Using Bifunctional Fatty Acids

    Per Haberkant;Reinout Raijmakers;Marjolein Wildwater;Timo Sachsenheimer

  • Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D

    Joost Holthuis;Thomas A. Owen;Andre J. van Wijnen;Kenneth L. Wright

Frequent Co-Authors

Thomas Günther Pomorski
Thomas Günther Pomorski Ruhr University Bochum
Gerard J. M. Martens
Gerard J. M. Martens Radboud University
Pentti Somerharju
Pentti Somerharju University of Helsinki
Gary S. Stein
Gary S. Stein University of Vermont
Thomas A. Owen
Thomas A. Owen Pfizer (United States)
Patrick Williamson
Patrick Williamson Amherst College
Jane B. Lian
Jane B. Lian University of Vermont
Hugh R.B. Pelham
Hugh R.B. Pelham MRC Laboratory of Molecular Biology
Janet L. Stein
Janet L. Stein University of Vermont
Leo W. J. Klomp
Leo W. J. Klomp Utrecht University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Joost C. M. Holthuis

Trending Scientists

Recently Published Articles