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Pentti Somerharju

Pentti Somerharju

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
10745
World Ranking
12135
National Ranking
87

Overview

Pentti Somerharju is affiliated with the University of Helsinki in Finland. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, with notable work in several subfields including Molecular Biology, Cell Biology, Biochemistry, and Physiology.

Their scientific contributions have been published in multiple venues, with articles appearing in the following journals and repositories:

  • FASEB BioAdvances
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)

Somerharju's research topics encompass several areas within molecular and cellular biology. The main topics include:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Lipid Membrane Structure and Behavior
  • Lipid metabolism and biosynthesis
  • Cellular transport and secretion
  • Endoplasmic Reticulum Stress and Disease
  • Adipose Tissue and Metabolism

Recent papers authored or coauthored by Somerharju provide insight into their research interests and contributions. These include:

  • "Hypothesis: Chemical activity regulates and coordinates the processes maintaining glycerophospholipid homeostasis in mammalian cells," published in 2020 in FASEB BioAdvances
  • "Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure," with versions published in 2021 in bioRxiv (Cold Spring Harbor Laboratory) and in 2023 in Proceedings of the National Academy of Sciences

Frequent coauthors working alongside Somerharju in their research include:

  • Svetlana Konovalova
  • Rubén Torregrosa-Muñumer
  • Pooja Manjunath
  • Xiaonan Liu
  • Sundar Baral

Best Publications

  • Elevated globotriaosylsphingosine is a hallmark of Fabry disease

    Johannes M. Aerts;Johanna E. Groener;Sijmen Kuiper;Wilma E. Donker-Koopman

  • Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response.

    Mirkka Koivusalo;Perttu Haimi;Liisa Heikinheimo;Risto Kostiainen

  • Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

    Sanna Heino;Sari Lusa;Pentti Somerharju;Christian Ehnholm

  • Phospholipid composition of the mammalian red cell membrane can be rationalized by a superlattice model

    Jorma A Virtanen;Kwan H Cheng;Pentti Somerharju

  • Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells

    Fikadu Geta Tafesse;Klazien Huitema;Martin Hermansson;Seleéne van der Poel

  • 1-Palmitoyl-2-pyrenedecanoyl glycerophospholipids as membrane probes: evidence for regular distribution in liquid-crystalline phosphatidylcholine bilayers.

    Pentti J. Somerharju;Jorma A. Virtanen;Kari K. Eklund;Petri Vainio

  • Mechanisms of glycerophospholipid homeostasis in mammalian cells.

    Martin Hermansson;Kati Hokynar;Pentti Somerharju

  • Lateral organisation of membrane lipids. The superlattice view.

    Pentti Somerharju;Jorma A. Virtanen;Kwan Hon Cheng

  • Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.

    Gregory D Fairn;Martin Hermansson;Pentti Somerharju;Sergio Grinstein

  • Automated quantitative analysis of complex lipidomes by liquid chromatography/mass spectrometry.

    Martin Hermansson;Andreas Uphoff;Reijo Käkelä;Pentti Somerharju

  • The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion

    Sari Lusa;Matti Jauhiainen;Jari Metso;Pentti Somerharju

  • Pyrene-labeled lipids as tools in membrane biophysics and cell biology

    Pentti Somerharju

  • Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

    Ana M. Vacaru;Fikadu G. Tafesse;Philipp Ternes;Vangelis Kondylis

  • Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

    Veijo T. Salo;Shiqian Li;Shiqian Li;Helena Vihinen;Maarit Hölttä-Vuori;Maarit Hölttä-Vuori

  • Analysis of phospholipid molecular species in brains from patients with infantile and juvenile neuronal-ceroid lipofuscinosis using liquid chromatography-electrospray ionization mass spectrometry.

    Reijo Käkelä;Pentti Somerharju;Jaana Tyynelä

  • ABC lipid transporters: extruders, flippases, or flopless activators?

    Gerrit van Meer;David Halter;Hein Sprong;Pentti Somerharju

  • Modulation of cellular cholesterol transport and homeostasis by Rab11

    Maarit Hölttä-Vuori;Kimmo Tanhuanpää;Wiebke Möbius;Pentti Somerharju

  • Lateral organization of liquid-crystalline cholesterol-dimyristoylphosphatidylcholine bilayers. Evidence for domains with hexagonal and centered rectangular cholesterol superlattices.

    Jorma Virtanen;Mika Ruonala;Matti Vauhkonen;Pentti Somerharju

  • Membrane binding mechanism of an RNA virus-capping enzyme.

    Anja Lampio;Ilkka Kilpeläinen;Saara Pesonen;Kimmo Karhi

  • Binding of cytochrome c to liposomes as revealed by the quenching of fluorescence from pyrene-labeled phospholipids

    Pekka Mustonen;Jorma A. Virtanen;Pentti J. Somerharju;Paavo K. J. Kinnunen

Frequent Co-Authors

Karel W. A. Wirtz
Karel W. A. Wirtz Utrecht University
Elina Ikonen
Elina Ikonen University of Helsinki
Joost C. M. Holthuis
Joost C. M. Holthuis Osnabrück University
Vesa M. Olkkonen
Vesa M. Olkkonen University of Helsinki
Dennis H. Bamford
Dennis H. Bamford University of Helsinki
Christian Ehnholm
Christian Ehnholm Finnish Institute for Health and Welfare (THL)
Paavo K.J. Kinnunen
Paavo K.J. Kinnunen Aalto University
Vytas A. Bankaitis
Vytas A. Bankaitis Texas A&M University
Johan Peränen
Johan Peränen University of Helsinki
Ossi Renkonen
Ossi Renkonen University of Helsinki

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