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Johannes M. F. G. Aerts

Johannes M. F. G. Aerts

D-Index & Metrics

Medicine

D-Index
103
Citations
32111
World Ranking
7446
National Ranking
286

Overview

Johannes M. F. G. Aerts is affiliated with Leiden University in the Netherlands and has an extensive research record in the fields of medicine and biochemistry, genetics, and molecular biology. Their work broadly spans several interconnected subfields, including physiology, molecular biology, organic chemistry, cell biology, and epidemiology.

The scientist's primary topics of research include lysosomal storage disorders, carbohydrate chemistry and synthesis, glycosylation and glycoproteins, cellular transport and secretion, Trypanosoma species and their implications, sphingolipid metabolism and signaling, as well as calcium signaling and nucleotide metabolism.

Aerts has contributed numerous papers to scientific journals and has frequently collaborated with a set of researchers. Their most frequent co-authors are Herman S. Overkleeft, Maria J. Ferraz, Marta Artola, Rolf G. Boot, and Jeroen D. C. Codée.

Publications by Johannes M. F. G. Aerts appear regularly in several key research venues, including Molecular Genetics and Metabolism, Journal of Lipid Research, International Journal of Molecular Sciences, Journal of the American Chemical Society, and ChemBioChem.

Some recent publications by this researcher include:

  • Current methods to analyze lysosome morphology, positioning, motility and function, 2022, Traffic
  • Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, 2020, Frontiers in Plant Science
  • The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease, 2020, Movement Disorders
  • Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions, 2021, Biomolecules
  • Glucocerebrosidase: Functions in and Beyond the Lysosome, 2020, Journal of Clinical Medicine

Best Publications

  • Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease.

    C. E. M. Hollak;S. Van Weely;M. H. J. Van Oers;J. M. F. G. Aerts

  • Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis

    T Cox;R Lachmann;C Hollak;J Aerts

  • Elevated globotriaosylsphingosine is a hallmark of Fabry disease

    Johannes M. Aerts;Johanna E. Groener;Sijmen Kuiper;Wilma E. Donker-Koopman

  • Identification of a novel acidic mammalian chitinase distinct from chitotriosidase

    R.G. Boot;E.F.C. Blommaart;E. Swart;K. Ghauharali-Van der Vlugt

  • Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages

    R.G. Boot;G.H. Renkema;A. Strijland;A.J. van Zonneveld

  • The human chitotriosidase gene - Nature of inherited enzyme deficiency

    R.G. Boot;G.H. Renkema;M. Verhoek;A. Strijland

  • Chitotriosidase, a chitinase, and the 39‐kDa human cartilage glycoprotein, a chitin‐binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

    G. H. Renkema;R. G. Boot;F. L. Au;W. E. Donker-Koopman

  • Strong Induction of Members of the Chitinase Family of Proteins in Atherosclerosis Chitotriosidase and Human Cartilage gp-39 Expressed in Lesion Macrophages

    R. G. Boot;T. A. E. Van Achterberg;B. E. Van Aken;G. H. Renkema

  • Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.

    Leonie A Boven;Marjan Van Meurs;Marloes Van Zwam;Annet Wierenga-Wolf

  • Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention.

    Rolf G. Boot;Marri Verhoek;Maaike de Fost;Carla E. M. Hollak

  • Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins.

    G.H. Renkema;R.G. Boot;A.O. Muijsers;W.E. Donker-Koopman

  • Glycosphingolipids—Nature, Function, and Pharmacological Modulation

    Tom Wennekes;Richard J. B. H. N. van den Berg;Rolf G. Boot;Gijsbert A. van der Marel

  • Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity.

    Marco van Eijk;Cindy P. A. A. van Roomen;G. Herma Renkema;Anton P. Bussink

  • Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases.

    Anton P. Bussink;Dave Speijer;Johannes M. F. G. Aerts;Rolf G. Boot

  • Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages.

    Leonie A. Boven;Marjan van Meurs;Rolf G. Boot;Atul Mehta

  • Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

    Nick Dekker;Laura van Dussen;Carla E. M. Hollak;Herman Overkleeft

  • Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

    Johannes M. Aerts;Roelof Ottenhoff;Andrew S. Powlson;Aldo Grefhorst

  • Enzyme therapy for Fabry disease: neutralizing antibodies toward agalsidase alpha and beta.

    Gabor E. Linthorst;Carla E.M. Hollak;Wilma E. Donker-Koopman;Anneke Strijland

  • Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease.

    D. Elstein;C. Hollak;J. M. F. G. Aerts;S. van Weely

  • Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.

    Fabrizia Fusetti;Holger von Moeller;Douglas Houston;Henriëtte J. Rozeboom

Frequent Co-Authors

Rolf G. Boot
Rolf G. Boot Leiden University
Herman S. Overkleeft
Herman S. Overkleeft Leiden University
Jeroen D. C. Codée
Jeroen D. C. Codée Leiden University
J. M. Tager
J. M. Tager University of Amsterdam
John A. Barranger
John A. Barranger University of Pittsburgh
Gideon J. Davies
Gideon J. Davies University of York
Timothy M. Cox
Timothy M. Cox University of Cambridge
Frits A. Wijburg
Frits A. Wijburg University of Amsterdam
Albert K. Groen
Albert K. Groen University of Amsterdam
Huib Ovaa
Huib Ovaa Leiden University Medical Center

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