His scientific interests lie mostly in Internal medicine, Immunology, Enzyme, Biochemistry and Glucocerebrosidase. His Internal medicine research integrates issues from Gastroenterology and Endocrinology. His Enzyme research is multidisciplinary, relying on both Gastrointestinal tract, Moiety and Macrophage.
Johannes M. F. G. Aerts has included themes like Molecular biology and Function in his Biochemistry study. His research in Glucocerebrosidase intersects with topics in Spleen, Substrate reduction therapy, Pathophysiology and Miglustat. Johannes M. F. G. Aerts has researched Fabry disease in several fields, including Renal function and Enzyme replacement therapy.
His main research concerns Internal medicine, Biochemistry, Glucocerebrosidase, Endocrinology and Enzyme. Internal medicine is closely attributed to Gastroenterology in his study. His research in Glucocerebrosidase focuses on subjects like Immunology, which are connected to Macrophage.
His study in Endocrinology is interdisciplinary in nature, drawing from both Lysosomal storage disease and Iminosugar. His biological study spans a wide range of topics, including Stereochemistry and Recombinant DNA. In his research, Antibody is intimately related to Fabry disease, which falls under the overarching field of Enzyme replacement therapy.
Johannes M. F. G. Aerts mostly deals with Biochemistry, Enzyme, Stereochemistry, Glucocerebrosidase and Fabry disease. His research in Enzyme tackles topics such as Glycolipid which are related to areas like Cytosol and Sphingolipid. Johannes M. F. G. Aerts interconnects Cyclophellitol, Covalent bond, Aziridine and Glycoside hydrolase in the investigation of issues within Stereochemistry.
The various areas that he examines in his Glucocerebrosidase study include Endocrinology, Endogeny, Cholesterol and Lysosome. His Endocrinology study combines topics in areas such as Receptor, Stratum corneum and Epidermis. Fabry disease is a subfield of Internal medicine that Johannes M. F. G. Aerts investigates.
Johannes M. F. G. Aerts mainly investigates Biochemistry, Glucocerebrosidase, Glucosylceramidase, Enzyme and Lysosome. Biochemistry is closely attributed to Assimilation in his work. His studies deal with areas such as Cell, In vitro, Phenotype, Glycosphingolipid and Metabolism as well as Glucocerebrosidase.
His Glucosylceramidase course of study focuses on Activity-based proteomics and In vivo and Conduritol B-epoxide. His work on Hydrolase as part of general Enzyme research is often related to Heparanase, thus linking different fields of science. His Galactocerebrosidase study spans across into areas like Endocrinology and Internal medicine.
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Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease.
C. E. M. Hollak;S. Van Weely;M. H. J. Van Oers;J. M. F. G. Aerts.
Journal of Clinical Investigation (1994)
Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis
T Cox;R Lachmann;C Hollak;J Aerts.
The Lancet (2000)
Elevated globotriaosylsphingosine is a hallmark of Fabry disease
Johannes M. Aerts;Johanna E. Groener;Sijmen Kuiper;Wilma E. Donker-Koopman.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Identification of a novel acidic mammalian chitinase distinct from chitotriosidase
R.G. Boot;E.F.C. Blommaart;E. Swart;K. Ghauharali-Van der Vlugt.
Journal of Biological Chemistry (2001)
Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages
R. G. Boot;G. H. Renkema;A. Strijland;A. J. Van Zonneveld.
Journal of Biological Chemistry (1995)
The human chitotriosidase gene - Nature of inherited enzyme deficiency
R.G. Boot;G.H. Renkema;M. Verhoek;A. Strijland.
Journal of Biological Chemistry (1998)
Chitotriosidase, a chitinase, and the 39‐kDa human cartilage glycoprotein, a chitin‐binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages
G. H. Renkema;R. G. Boot;F. L. Au;W. E. Donker-Koopman.
FEBS Journal (1998)
Strong Induction of Members of the Chitinase Family of Proteins in Atherosclerosis Chitotriosidase and Human Cartilage gp-39 Expressed in Lesion Macrophages
R. G. Boot;T. A. E. Van Achterberg;B. E. Van Aken;G. H. Renkema.
Arteriosclerosis, Thrombosis, and Vascular Biology (1999)
Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins.
G.H. Renkema;R.G. Boot;A.O. Muijsers;W.E. Donker-Koopman.
Journal of Biological Chemistry (1995)
Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention.
Rolf G. Boot;Marri Verhoek;Maaike de Fost;Carla E. M. Hollak.
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