World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
114
Citations
45810
World Ranking
413
National Ranking
254

Medicine

D-Index
114
Citations
45955
World Ranking
4759
National Ranking
2579

Research.com Recognitions

  • 2017 - Fellow, National Academy of Inventors

Overview

Jack A. Elias is affiliated with Brown University in the United States, conducting research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans a variety of subfields including Molecular Biology, Immunology, Pulmonary and Respiratory Medicine, Oncology, and Infectious Diseases.

Their research focuses on several main topics, notably studies on chitinases and chitosanases, peptidase inhibition and analysis, and interstitial lung diseases including idiopathic pulmonary fibrosis. Other areas include invertebrate immune response mechanisms, mosquito-borne diseases and control, extracellular vesicles in disease, and chronic obstructive pulmonary disease (COPD) research.

Jack A. Elias has contributed extensively to scientific literature, with frequent publications in venues such as bioRxiv (Cold Spring Harbor Laboratory), American Journal of Respiratory Cell and Molecular Biology, eLife, Science Advances, and the Journal of Clinical Investigation.

Among their recent published papers are:

  • Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis, 2020, Science Translational Medicine
  • The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer, 2023, Immunity
  • Potential role of chitinase-3-like protein 1 (CHI3L1/YKL-40) in neurodegeneration and Alzheimer's disease, 2022, Alzheimer s & Dementia
  • CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor responses, 2021, Journal of Clinical Investigation
  • Chi3l1 Is a Modulator of Glioma Stem Cell States and a Therapeutic Target in Glioblastoma, 2023, Cancer Research

The scientist collaborates frequently with several coauthors, including Chun Geun Lee, Suchitra Kamle, Bing Ma, Chang-Min Lee, and Bedia Akosman, reflecting an extensive network within their research community.

Jack A. Elias was recognized as a Fellow of the National Academy of Inventors in 2017.

Best Publications

  • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

    Zhou Zhu;Robert J. Homer;Robert J. Homer;Zhonde Wang;Qingsheng Chen

  • Proceedings of the ATS Workshop on Refractory Asthma Current Understanding, Recommendations, and Unanswered Questions

    Sally E. Wenzel;John V. Fahy;Charles Irvin;Stephen P. Peters

  • IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.

    Sophie Molet;Qutayba Hamid;Francis Davoine;Esra Nutku

  • Asthma: Mechanisms of Disease Persistence and Progression

    Lauren Cohn;Jack A. Elias;Geoffrey L. Chupp

  • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

    Douglas A. Kuperman;Xiaozhu Huang;Laura L. Koth;Grace H. Chang

  • Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

    Chun Geun Lee;Robert J. Homer;Zhou Zhu;Sophie Lanone

  • Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.

    Chun Geun Lee;Carla A. Da Silva;Charles S. Dela Cruz;Farida Ahangari

  • Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation

    Zhou Zhu;Tao Zheng;Robert J. Homer;Yoon Keun Kim

  • Airway remodeling in asthma.

    Jack A. Elias;Zhou Zhu;Geoffrey Chupp;Robert J. Homer

  • Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression

    Jamila Chakir;Joanne Shannon;Sophie Molet;Motonori Fukakusa

  • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.

    Chun Geun Lee;Holger Link;Peter Baluk;Robert J Homer

  • Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase– and cathepsin-dependent emphysema

    Tao Zheng;Zhou Zhu;Zhongde Wang;Robert J. Homer;Robert J. Homer

  • A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma

    Geoffrey L Chupp;Chun Geun Lee;Nizar Jarjour;Yun Michael Shim

  • Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function

    Carole Ober;Zheng Tan;Ying Sun;Jennifer D. Possick

  • New insights into the pathogenesis of asthma

    Jack A. Elias;Chun Geun Lee;Tao Zheng;Bing Ma

  • Interferon γ induction of pulmonary emphysema in the adult murine lung

    Zhongde Wang;Tao Zheng;Zhou Zhu;Robert J. Homer

  • Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

    Chun Geun Lee;Dominik Hartl;Gap Ryol Lee;Barbara Koller

  • Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

    Eun-Gyoung Hong;Hwi Jin Ko;Hwi Jin Ko;You-Ree Cho;You-Ree Cho;Hyo-Jeong Kim;Hyo-Jeong Kim

  • Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis

    Chun Geun Lee;Soo Jung Cho;Min Jong Kang;Svetlana P. Chapoval

  • Chitin regulation of immune responses: an old molecule with new roles.

    Chun Geun Lee;Carla A Da Silva;Jae-Young Lee;Dominik Hartl

  • Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions

    Masao Toda;Donald Y.M. Leung;Sophie Molet;Mark Boguniewicz

Frequent Co-Authors

Chun Geun Lee
Chun Geun Lee Brown University
Robert J. Homer
Robert J. Homer Yale University
Zhou Zhu
Zhou Zhu Brown University
Charles S. Dela Cruz
Charles S. Dela Cruz Yale University
Dominik Hartl
Dominik Hartl Novartis (Switzerland)
Richard A. Flavell
Richard A. Flavell Yale University
Patty J. Lee
Patty J. Lee Duke University
Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Anthony J. Coyle
Anthony J. Coyle Takeda (United States)
Marie L. Landry
Marie L. Landry Yale University

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