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Immunology

D-Index
102
Citations
49023
World Ranking
660
National Ranking
386

Overview

Anthony J. Coyle is affiliated with Takeda in the United States and has an extensive research portfolio focusing on medicine, immunology, and microbiology. Their work covers several subfields, including immunology, oncology, molecular biology, infectious diseases, and genetics.

Their research topics encompass immunotherapy and immune responses, cancer immunotherapy and biomarkers, CAR-T cell therapy research, vaccines and immunoinformatics approaches, T-cell and B-cell immunology, SARS-CoV-2 and COVID-19 research, and amyotrophic lateral sclerosis research.

Among notable recent publications are:

  • "Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2." (2022, PubMed)
  • "Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation." (2021, Cell Reports)
  • "Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure." (2021, bioRxiv (Cold Spring Harbor Laboratory))
  • "Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment." (2023, Journal for ImmunoTherapy of Cancer)
  • "Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma." (2024, Nature Immunology)

Frequent co-authors collaborating with Anthony J. Coyle include:

  • Daniel C. Pregibon
  • Joanna F. Swain
  • Brinda Vijaykumar
  • Del Leistritz-Edwards
  • T. Malia

Key venues for their publications are:

  • Regular and Young Investigator Award Abstracts
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PubMed
  • Cell Reports

Best Publications

  • IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

    Katherine A. Fitzgerald;Sarah M. McWhirter;Kerrie L. Faia;Daniel C. Rowe

  • Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

    Stephen E Girardin;Ivo G Boneca;Leticia A M Carneiro;Aude Antignac

  • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

    Laurent Monney;Catherine A. Sabatos;Jason L. Gaglia;Akemi Ryu

  • HMGB1 and RAGE in inflammation and cancer.

    Gary P. Sims;Daniel C. Rowe;Svend T. Rietdijk;Ronald Herbst

  • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

    Jane Tian;Ana Maria Avalos;Su-Yau Mao;Bo Chen

  • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

    Jerome Viala;Catherine Chaput;Ivo G Boneca;Ana Cardona

  • Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

    Luigi Franchi;Amal Amer;Mathilde Body-Malapel;Thirumala Devi Kanneganti

  • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

    Thirumala Devi Kanneganti;Nesrin Özören;Mathilde Body-Malapel;Amal Amer

  • Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1

    Fayyaz S. Sutterwala;Yasunori Ogura;Marian Szczepanik;Marian Szczepanik;Maria Lara-Tejero

  • Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance

    Alberto Sánchez-Fueyo;Jane Tian;Dominic Picarella;Christoph Domenig

  • Mast cells are essential intermediaries in regulatory T-cell tolerance.

    Li Fan Lu;Evan F. Lind;David C. Gondek;Kathy A. Bennett

  • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

    Catherine A Sabatos;Sumone Chakravarti;Eugene Cha;Anna Schubart

  • The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

    Anthony J. Coyle;Jose-Carlos Gutierrez-Ramos

  • The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

    Anthony J Coyle;Sophie Lehar;Clare Lloyd;Jane Tian

  • T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

    Max Löhning;Arne Stroehmann;Anthony J. Coyle;Jane L. Grogan

  • The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness

    Jose-Angel Gonzalo;Clare M. Lloyd;Danyi Wen;Juan P. Albar

  • MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

    Roland Kolbeck;Alexander Kozhich;Masamichi Koike;Li Peng

  • A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma

    Geoffrey L Chupp;Chun Geun Lee;Nizar Jarjour;Yun Michael Shim

  • Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

    Bart N. Lambrecht;Marijke De Veerman;Anthony J. Coyle;Jose-Carlos Gutierrez-Ramos

  • Continuous Exposure to House Dust Mite Elicits Chronic Airway Inflammation and Structural Remodeling

    Jill R. Johnson;Ryan E. Wiley;Ramzi Fattouh;Filip K. Swirski

Frequent Co-Authors

Jose-Carlos Gutierrez-Ramos
Jose-Carlos Gutierrez-Ramos Takeda (United States)
Manel Jordana
Manel Jordana McMaster University
Roland Kolbeck
Roland Kolbeck AstraZeneca (United Kingdom)
Clare M. Lloyd
Clare M. Lloyd Imperial College London
Martin R. Stämpfli
Martin R. Stämpfli McMaster University
Peter A. Kiener
Peter A. Kiener AstraZeneca (United Kingdom)
Cox Terhorst
Cox Terhorst Beth Israel Deaconess Medical Center
John Bertin
John Bertin GlaxoSmithKline (United Kingdom)
Jack A. Elias
Jack A. Elias Brown University
Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania

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