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Immunology

D-Index
64
Citations
17212
World Ranking
2913
National Ranking
264

Overview

Roland Kolbeck is affiliated with AstraZeneca in the United Kingdom and has contributed extensively to research in medicine, particularly in immunology and pulmonary and respiratory medicine. Their work spans multiple subfields, including physiology, surgery, and epidemiology, with a notable focus on respiratory diseases and immune system pathways.

The scientist's research addresses a variety of topics, including:

  • Neonatal Respiratory Health Research
  • Asthma and respiratory diseases
  • IL-33, ST2, and ILC Pathways
  • Eosinophilic Esophagitis
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Respiratory viral infections research
  • Atherosclerosis and Cardiovascular Diseases

Roland Kolbeck has published in several venues frequently, including:

  • European Respiratory Journal
  • PLoS ONE
  • Human Gene Therapy
  • Molecular Therapy - Methods & Clinical Development
  • Cellular and Molecular Immunology

Some of the recent papers include:

  • B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling (2020) in Cellular and Molecular Immunology
  • IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration (2020) in Nature Communications
  • Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex (2023) in European Respiratory Journal
  • Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue (2020) in European Respiratory Journal
  • Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity (2021) in European Respiratory Journal

Roland Kolbeck has collaborated frequently with several researchers, including:

  • Alison A. Humbles
  • Rania Dagher
  • Katherine J. D. A. Excoffon
  • Maria P. Limberis
  • Jingya Wang

Best Publications

  • Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

    Martin Kerschensteiner;Eike Gallmeier;Lüder Behrens;Vivian Vargas Leal

  • MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

    Roland Kolbeck;Alexander Kozhich;Masamichi Koike;Li Peng

  • Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

    Michel Laviolette;David L. Gossage;Gail Gauvreau;Richard Leigh

  • Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

    Mario Castro;Sally E Wenzel;Eugene R Bleecker;Emilio Pizzichini

  • IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.

    Shu Wang;Jingya Wang;Varsha Kumar;Jodi L Karnell

  • Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

    Jonathan S Silver;Jennifer Kearley;Alan M Copenhaver;Caroline Sanden

  • Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

    Tomoya Matsumoto;Stefanie Rauskolb;Martin Polack;Johannes Klose

  • Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma

    William W. Busse;Rohit Katial;David Gossage;Suha Sari

  • IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization

    Derek K. Chu;Alba Llop-Guevara;Tina D. Walker;Kristin Flader

  • Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

    Jill Henault;Jennifer Martinez;Jeffrey M. Riggs;Jane Tian

  • Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.

    Jennifer Kearley;Jonathan S. Silver;Caroline Sanden;Zheng Liu

  • Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity

    Marco Canossa;Oliver Griesbeck;Benedikt Berninger;Gabriele Campana

  • Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond.

    Jodi L. Karnell;Sadiye Amcaoglu Rieder;Rachel Ettinger;Roland Kolbeck

  • Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation

    Guiquan Chen;Roland Kolbeck;Yves-Alain Barde;Tobias Bonhoeffer

  • Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

    H.-P. Hohmann;M. Brockhaus;P. A. Baeuerle;R. Remy

  • Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

    Sarah L. Rowland;Jeffrey M. Riggs;Susan Gilfillan;Mattia Bugatti

  • Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease

    Nassima Ferhani;Séverine Letuve;Alexander Kozhich;Olivier Thibaudeau

  • IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.

    Jennifer Kearley;Jonas S. Erjefalt;Cecilia Andersson;Ebony Benjamin

  • Molecular and clinical rationale for therapeutic targeting of interleukin‐5 and its receptor

    N. A. Molfino;D. Gossage;R. Kolbeck;J. M. Parker

  • RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

    Cherilyn M. Sirois;Cherilyn M. Sirois;Tengchuan Jin;Allison L. Miller;Damien Bertheloot

  • Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root

    Daniel Teupser;Stephanos Pavlides;Marietta Tan;Jose-Carlos Gutierrez-Ramos

Frequent Co-Authors

Yves-Alain Barde
Yves-Alain Barde Cardiff University
Martin R. Stämpfli
Martin R. Stämpfli McMaster University
Ronald Herbst
Ronald Herbst Biolojic Design
Manel Jordana
Manel Jordana McMaster University
Anthony J. Coyle
Anthony J. Coyle Takeda (United States)
Derek K. Chu
Derek K. Chu McMaster University
Jonas S. Erjefält
Jonas S. Erjefält Lund University
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Peter A. Kiener
Peter A. Kiener AstraZeneca (United Kingdom)
Tomas Mustelin
Tomas Mustelin University of Washington

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