D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge Research.com 2022 Best Female Scientist Award Badge

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 137 Citations 86,026 352 World Ranking 57 National Ranking 41
Medicine D-index 144 Citations 93,853 401 World Ranking 540 National Ranking 331
Best female scientists D-index 161 Citations 113,622 530 World Ranking 59 National Ranking 41
Best Scientists D-index 161 Citations 113,622 530 World Ranking 795 National Ranking 513

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Female Scientist Award

2022 - Research.com Best Scientist Award

2020 - Fellow, National Academy of Inventors

2018 - Member of the National Academy of Sciences

2018 - Member of the National Academy of Medicine (NAM)

2017 - Warren Alpert Foundation Prize For their collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.

2006 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Immune system
  • Cancer

Arlene H. Sharpe spends much of her time researching Immunology, Cell biology, T cell, Immune system and Cytotoxic T cell. Her Immunology study combines topics in areas such as Cancer research and Cellular differentiation. Her studies deal with areas such as Cell, Immune tolerance, Molecular biology, Programmed Cell Death 1 Ligand 2 Protein and Receptor as well as Cell biology.

Her biological study spans a wide range of topics, including Chronic infection, Haematopoiesis and Transplantation. Her Immune system research incorporates themes from Melanoma and Effector. Her Cytotoxic T cell study frequently draws parallels with other fields, such as CD8.

Her most cited work include:

  • PD-1 and its ligands in tolerance and immunity (3450 citations)
  • Restoring function in exhausted CD8 T cells during chronic viral infection. (3059 citations)
  • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 (2370 citations)

What are the main themes of her work throughout her whole career to date?

Her main research concerns Immunology, T cell, Cell biology, Immune system and Cytotoxic T cell. Her research in Antigen, Autoimmunity, CTLA-4, Antibody and Germinal center are components of Immunology. The various areas that Arlene H. Sharpe examines in her T cell study include Molecular biology and Cell.

Arlene H. Sharpe combines subjects such as Receptor, Cellular differentiation and CD40 with her study of Cell biology. Immune system connects with themes related to Inflammation in her study. In Cytotoxic T cell, she works on issues like CD8, which are connected to Cancer research.

She most often published in these fields:

  • Immunology (49.68%)
  • T cell (46.97%)
  • Cell biology (38.38%)

What were the highlights of her more recent work (between 2017-2021)?

  • Cancer research (25.16%)
  • CD8 (26.91%)
  • T cell (46.97%)

In recent papers she was focusing on the following fields of study:

Cancer research, CD8, T cell, Cancer and Cytotoxic T cell are her primary areas of study. Arlene H. Sharpe has researched Cancer research in several fields, including Blockade and Immunotherapy, Immune system, Cancer immunotherapy. Her work carried out in the field of CD8 brings together such families of science as Transcriptome and Melanoma.

Her work deals with themes such as Cell, Immune tolerance, Antigen and Cell biology, which intersect with T cell. Her Cytotoxic T cell study integrates concerns from other disciplines, such as Molecular biology and Receptor. Her Autoimmunity research is under the purview of Immunology.

Between 2017 and 2021, her most popular works were:

  • The diverse functions of the PD1 inhibitory pathway. (561 citations)
  • Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. (438 citations)
  • Defining ‘T cell exhaustion’ (270 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Cancer

Her primary scientific interests are in Cancer research, Immune system, Immunotherapy, T cell and CD8. The study of Immunology and Internal medicine are components of her Immunotherapy research. Her Immunology study frequently draws connections between adjacent fields such as Insulin resistance.

Her studies in T cell integrate themes in fields like mTORC1, Immune tolerance and Cell biology. Her Cell biology research incorporates elements of Cell, Cellular differentiation, Leucine, Regulatory T cell and Glutamine. Her CD8 study incorporates themes from Cytotoxic T cell, Carcinoma, Progenitor and Cell culture.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

PD-1 and its ligands in tolerance and immunity.

Mary E. Keir;Manish J. Butte;Gordon J. Freeman;Arlene H. Sharpe.
Annual Review of Immunology (2008)

4435 Citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth A. Tivol;Frank Borriello;A.Nicola Schweitzer;William P. Lynch.
Immunity (1995)

3772 Citations

Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber;E. John Wherry;David Masopust;Baogong Zhu.
Nature (2006)

3738 Citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Yvette Latchman;Clive R. Wood;Tatyana Chernova;Divya Chaudhary.
Nature Immunology (2001)

2801 Citations

THE B7 FAMILY REVISITED

Rebecca J. Greenwald;Gordon J. Freeman;Arlene H. Sharpe.
Annual Review of Immunology (2005)

2709 Citations

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Annie Yang;Ronen Schweitzer;Deqin Sun;Mourad Kaghad.
Nature (1999)

2519 Citations

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

Benoît Salomon;Deborah J Lenschow;Lesley Rhee;Neda Ashourian.
Immunity (2000)

2339 Citations

The B7–CD28 superfamily

Arlene H Sharpe;Gordon J Freeman.
Nature Reviews Immunology (2002)

2122 Citations

The PD‐1 pathway in tolerance and autoimmunity

Loise M. Francisco;Peter T. Sage;Arlene H. Sharpe;Arlene H. Sharpe.
Immunological Reviews (2010)

2049 Citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Qing Wang;Terryl Stacy;Michael Binder;Miguel Marin-Padilla.
Proceedings of the National Academy of Sciences of the United States of America (1996)

1651 Citations

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