What is she best known for?
The fields of study she is best known for:
- Gene
- Immune system
- Cancer
Arlene H. Sharpe spends much of her time researching Immunology, Cell biology, T cell, Immune system and Cytotoxic T cell.
Her Immunology study combines topics in areas such as Cancer research and Cellular differentiation.
Her studies deal with areas such as Cell, Immune tolerance, Molecular biology, Programmed Cell Death 1 Ligand 2 Protein and Receptor as well as Cell biology.
Her biological study spans a wide range of topics, including Chronic infection, Haematopoiesis and Transplantation.
Her Immune system research incorporates themes from Melanoma and Effector.
Her Cytotoxic T cell study frequently draws parallels with other fields, such as CD8.
Her most cited work include:
- PD-1 and its ligands in tolerance and immunity (3450 citations)
- Restoring function in exhausted CD8 T cells during chronic viral infection. (3059 citations)
- Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 (2370 citations)
What are the main themes of her work throughout her whole career to date?
Her main research concerns Immunology, T cell, Cell biology, Immune system and Cytotoxic T cell.
Her research in Antigen, Autoimmunity, CTLA-4, Antibody and Germinal center are components of Immunology.
The various areas that Arlene H. Sharpe examines in her T cell study include Molecular biology and Cell.
Arlene H. Sharpe combines subjects such as Receptor, Cellular differentiation and CD40 with her study of Cell biology.
Immune system connects with themes related to Inflammation in her study.
In Cytotoxic T cell, she works on issues like CD8, which are connected to Cancer research.
She most often published in these fields:
- Immunology (49.68%)
- T cell (46.97%)
- Cell biology (38.38%)
What were the highlights of her more recent work (between 2017-2021)?
- Cancer research (25.16%)
- CD8 (26.91%)
- T cell (46.97%)
In recent papers she was focusing on the following fields of study:
Cancer research, CD8, T cell, Cancer and Cytotoxic T cell are her primary areas of study.
Arlene H. Sharpe has researched Cancer research in several fields, including Blockade and Immunotherapy, Immune system, Cancer immunotherapy.
Her work carried out in the field of CD8 brings together such families of science as Transcriptome and Melanoma.
Her work deals with themes such as Cell, Immune tolerance, Antigen and Cell biology, which intersect with T cell.
Her Cytotoxic T cell study integrates concerns from other disciplines, such as Molecular biology and Receptor.
Her Autoimmunity research is under the purview of Immunology.
Between 2017 and 2021, her most popular works were:
- The diverse functions of the PD1 inhibitory pathway. (561 citations)
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. (438 citations)
- Defining ‘T cell exhaustion’ (270 citations)
In her most recent research, the most cited papers focused on:
- Gene
- Immune system
- Cancer
Her primary scientific interests are in Cancer research, Immune system, Immunotherapy, T cell and CD8.
The study of Immunology and Internal medicine are components of her Immunotherapy research.
Her Immunology study frequently draws connections between adjacent fields such as Insulin resistance.
Her studies in T cell integrate themes in fields like mTORC1, Immune tolerance and Cell biology.
Her Cell biology research incorporates elements of Cell, Cellular differentiation, Leucine, Regulatory T cell and Glutamine.
Her CD8 study incorporates themes from Cytotoxic T cell, Carcinoma, Progenitor and Cell culture.
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