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Biology and Biochemistry

D-Index
78
Citations
39203
World Ranking
4434
National Ranking
2154

Overview

Marcia C. Haigis is a researcher affiliated with Harvard University in the United States. Their work spans multiple fields, including biochemistry, genetics, molecular biology, and medicine. Within these broad areas, Haigis has contributed extensively to subfields such as molecular biology, immunology, cancer research, oncology, and physiology.

The scientist's research focuses on several main topics, including:

  • Cancer, hypoxia, and metabolism
  • Immune cell function and interaction
  • Cancer immunotherapy and biomarkers
  • Immune cells in cancer
  • Metabolomics and mass spectrometry studies
  • Mitochondrial function and pathology
  • RNA modifications and cancer

Haigis has co-authored numerous papers with frequent collaborators such as Shakchhi Joshi, Arlene H. Sharpe, Kiran Kurmi, Alison E. Ringel, and Cong-Hui Yao.

The scientist has published regularly in a variety of venues. Prominent journals and platforms for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cell Metabolism
  • Trends in Cell Biology
  • Cell

Notable recent papers include:

  • Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity, 2020, Cell
  • Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism, 2021, Nature Metabolism
  • Metabolic modeling of single Th17 cells reveals regulators of autoimmunity, 2021, Cell
  • The aging lung: Physiology, disease, and immunity, 2021, Cell
  • Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity, 2021, Molecular Cell

Haigis's research integrates insights from molecular processes, metabolism, and immune system interactions, particularly within the contexts of cancer and physiology. Their scientific output contributes to understanding cellular metabolism's role in tumor environments, immune regulation, and aging-related changes in organ function.

Best Publications

  • Mammalian sirtuins: biological insights and disease relevance.

    Marcia C. Haigis;David A. Sinclair

  • Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

    Jaekyoung Son;Costas A. Lyssiotis;Costas A. Lyssiotis;Haoqiang Ying;Xiaoxu Wang

  • Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

    Marcia C. Haigis;Leonard P. Guarente

  • Pancreatic cancers require autophagy for tumor growth

    Shenghong Yang;Xiaoxu Wang;Gianmarco Contino;Marc Liesa

  • The multifaceted contributions of mitochondria to cellular metabolism.

    Jessica B. Spinelli;Marcia C. Haigis

  • Mitochondria and Cancer

    Sejal Vyas;Elma Zaganjor;Marcia C. Haigis

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

    Valerie S. LeBleu;Joyce T. O’Connell;Karina N. Gonzalez Herrera;Harriet Wikman

  • SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

    Takashi Nakagawa;David J. Lomb;Marcia C. Haigis;Leonard Pershing Guarente

  • Calorie restriction extends yeast life span by lowering the level of NADH

    Su Ju Lin;Ethan Ford;Marcia Haigis;Greg Liszt

  • SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

    Lydia W.S. Finley;Arkaitz Carracedo;Jaewon Lee;Amanda Souza

  • Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

    Eric Verdin;Matthew D. Hirschey;Lydia W.S. Finley;Marcia C. Haigis

  • The Aging Stress Response

    Marcia C. Haigis;Bruce A. Yankner

  • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

    Kevin M Haigis;Krystle R Kendall;Yufang Wang;Ann Cheung

  • The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

    Alfred Csibi;Sarah-Maria Fendt;Chenggang Li;George Poulogiannis

  • SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

    Seung Min Jeong;Cuiying Xiao;Lydia W.S. Finley;Tyler Lahusen

  • Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

    Alison E. Ringel;Jefte M. Drijvers;Jefte M. Drijvers;Gregory J. Baker;Alessia Catozzi;Alessia Catozzi

  • SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

    Gaëlle Laurent;Natalie J. German;Asish K. Saha;Vincent C.J. de Boer

  • Accumulation of succinate controls activation of adipose tissue thermogenesis.

    Evanna L. Mills;Kerry A. Pierce;Mark P. Jedrychowski;Ryan Garrity

Frequent Co-Authors

Arlene H. Sharpe
Arlene H. Sharpe Harvard University
William G. Kaelin
William G. Kaelin Harvard University
Steven P. Gygi
Steven P. Gygi Harvard University
Clary B. Clish
Clary B. Clish Broad Institute
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Carla F. Kim
Carla F. Kim Boston Children's Hospital
Rameen Beroukhim
Rameen Beroukhim Harvard University

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