What is he best known for?
The fields of study he is best known for:
Biochemistry, SIRT5, Sirtuin, Molecular biology and Mitochondrion are his primary areas of study.
His work on Biochemistry is being expanded to include thematically relevant topics such as Cell biology.
His SIRT5 study is associated with Acetylation.
His work carried out in the field of Sirtuin brings together such families of science as ATG8, Autophagy, Autophagy-Related Protein 7 and Sirtuin 1.
The Molecular biology study combines topics in areas such as Cytotoxic T cell, Naive B cell, CD40 and Antigen-presenting cell.
His Mitochondrion study deals with SIRT3 intersecting with Calorie restriction and Insulin resistance.
His most cited work include:
- Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 (1156 citations)
- SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (1093 citations)
- A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy (967 citations)
What are the main themes of his work throughout his whole career to date?
David B. Lombard mostly deals with Cell biology, Sirtuin, Biochemistry, Cancer research and SIRT5.
His Cell biology research incorporates elements of DNA, DNA damage, Genotoxic Stress, Molecular biology and Regulator.
His work in DNA damage covers topics such as Senescence which are related to areas like Genome instability and Mutant.
He works on Sirtuin which deals in particular with SIRT6.
His SIRT6 research includes elements of Cancer cell, Warburg effect, Chromatin, Histone deacetylase and DNA repair.
The various areas that David B. Lombard examines in his SIRT5 study include Calorie restriction, Succinylation and Citric acid cycle, Metabolism.
He most often published in these fields:
- Cell biology (30.97%)
- Sirtuin (30.09%)
- Biochemistry (24.78%)
What were the highlights of his more recent work (between 2017-2021)?
- Cancer research (17.70%)
- Cell biology (30.97%)
- Melanoma (7.08%)
In recent papers he was focusing on the following fields of study:
David B. Lombard mostly deals with Cancer research, Cell biology, Melanoma, Sirtuin and Context.
The concepts of his Cancer research study are interwoven with issues in Aldehyde dehydrogenase, Cancer, Epigenetics and SIRT3.
His work on Mitochondrion as part of his general Cell biology study is frequently connected to Transcriptome, thereby bridging the divide between different branches of science.
His Melanoma research includes themes of Immune checkpoint and Histone.
David B. Lombard has researched Sirtuin in several fields, including Skin cancer, Oncogene, Microphthalmia-associated transcription factor, Cutaneous melanoma and Cellular homeostasis.
In his study, SIRT5 and Glycolysis is inextricably linked to Citric acid cycle, which falls within the broad field of Cellular homeostasis.
Between 2017 and 2021, his most popular works were:
- Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology. (55 citations)
- A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. (34 citations)
- Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma. (16 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Cancer research, Mitochondrion, Cell biology, Cancer and Cytokine.
His Cancer research research integrates issues from Hematopoietic stem cell transplantation, T cell, SIRT3, Macrophage and Type 2 diabetes.
His studies deal with areas such as Oxidative stress, Cell, Cellular differentiation, Pachyonychia congenita and Innate immune system as well as Mitochondrion.
His Cell biology research is multidisciplinary, incorporating perspectives in Sirtuin, Palmoplantar keratoderma and Keratin.
His Cancer study combines topics in areas such as EZH2, Epigenetics, SUZ12 and Bromodomain.
His Cytokine research is multidisciplinary, relying on both Autophagy, Dendritic cell, Immune system, Immunity and Sirtuin 1.
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