Biochemistry, SIRT5, Sirtuin, Molecular biology and Mitochondrion are his primary areas of study. His work on Biochemistry is being expanded to include thematically relevant topics such as Cell biology. His SIRT5 study is associated with Acetylation.
His work carried out in the field of Sirtuin brings together such families of science as ATG8, Autophagy, Autophagy-Related Protein 7 and Sirtuin 1. The Molecular biology study combines topics in areas such as Cytotoxic T cell, Naive B cell, CD40 and Antigen-presenting cell. His Mitochondrion study deals with SIRT3 intersecting with Calorie restriction and Insulin resistance.
David B. Lombard mostly deals with Cell biology, Sirtuin, Biochemistry, Cancer research and SIRT5. His Cell biology research incorporates elements of DNA, DNA damage, Genotoxic Stress, Molecular biology and Regulator. His work in DNA damage covers topics such as Senescence which are related to areas like Genome instability and Mutant.
He works on Sirtuin which deals in particular with SIRT6. His SIRT6 research includes elements of Cancer cell, Warburg effect, Chromatin, Histone deacetylase and DNA repair. The various areas that David B. Lombard examines in his SIRT5 study include Calorie restriction, Succinylation and Citric acid cycle, Metabolism.
David B. Lombard mostly deals with Cancer research, Cell biology, Melanoma, Sirtuin and Context. The concepts of his Cancer research study are interwoven with issues in Aldehyde dehydrogenase, Cancer, Epigenetics and SIRT3. His work on Mitochondrion as part of his general Cell biology study is frequently connected to Transcriptome, thereby bridging the divide between different branches of science.
His Melanoma research includes themes of Immune checkpoint and Histone. David B. Lombard has researched Sirtuin in several fields, including Skin cancer, Oncogene, Microphthalmia-associated transcription factor, Cutaneous melanoma and Cellular homeostasis. In his study, SIRT5 and Glycolysis is inextricably linked to Citric acid cycle, which falls within the broad field of Cellular homeostasis.
The scientist’s investigation covers issues in Cancer research, Mitochondrion, Cell biology, Cancer and Cytokine. His Cancer research research integrates issues from Hematopoietic stem cell transplantation, T cell, SIRT3, Macrophage and Type 2 diabetes. His studies deal with areas such as Oxidative stress, Cell, Cellular differentiation, Pachyonychia congenita and Innate immune system as well as Mitochondrion.
His Cell biology research is multidisciplinary, incorporating perspectives in Sirtuin, Palmoplantar keratoderma and Keratin. His Cancer study combines topics in areas such as EZH2, Epigenetics, SUZ12 and Bromodomain. His Cytokine research is multidisciplinary, relying on both Autophagy, Dendritic cell, Immune system, Immunity and Sirtuin 1.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang.
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey;Tadahiro Shimazu;Tadahiro Shimazu;Eric Goetzman;Enxuan Jing.
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee;Liu Cao;Raul Mostoslavsky;David B. Lombard.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg.
Molecular and Cellular Biology (2007)
DNA Repair, Genome Stability, and Aging
David B. Lombard;Katrin F. Chua;Raul Mostoslavsky;Sonia Franco.
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Jeongsoon Park;Yue Chen;Daniel X. Tishkoff;Chao Peng.
Molecular Cell (2013)
The first identification of lysine malonylation substrates and its regulatory enzyme
Chao Peng;Zhike Lu;Zhongyu Xie;Zhongyi Cheng.
Molecular & Cellular Proteomics (2011)
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Carlos Sebastián;Bernardette M. M. Zwaans;Dafne Magali Silberman;Dafne Magali Silberman;Melissa Gymrek.
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
Minjia Tan;Chao Peng;Kristin A. Anderson;Peter Chhoy.
Cell Metabolism (2014)
Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally
Yu Zhang;So Hee Kwon;Teppei Yamaguchi;Fabien Cubizolles.
Molecular and Cellular Biology (2008)
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