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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
24090
World Ranking
13522
National Ranking
5735

Overview

David B. Lombard is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a total of 76 publications in medicine and 62 in biochemistry and related fields.

Their primary subfields of study include molecular biology, physiology, geriatrics and gerontology, oncology, and cancer research. These fields intersect with main topics such as sirtuins and resveratrol in medicine, epigenetics and DNA methylation, adipose tissue and metabolism, cancer, hypoxia, and metabolism, pancreatic and hepatic oncology research, autophagy in disease and therapy, and mitochondrial function and pathology.

Recent papers by David B. Lombard cover diverse topics in cancer biology, metabolism, and genetics. Notable publications include:

  • Melanoma models for the next generation of therapies (2021, Cancer Cell)
  • Familial Clonal Hematopoiesis in a Long Telomere Syndrome (2023, New England Journal of Medicine)
  • Canagliflozin extends life span in genetically heterogeneous male but not female mice (2020, JCI Insight)
  • Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context (2022, eLife)
  • Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells (2020, PLoS Pathogens)

David B. Lombard frequently collaborates with several researchers, including Surinder Kumar, Mary E. Skinner, Costas A. Lyssiotis, Richard A. Miller, and Angela H. Guo. These collaborations contribute to a substantial body of work in various high-impact venues.

The scientist has published multiple papers in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Neuro-Oncology, JCI Insight, and Scientific Reports. BioRxiv hosts the highest number of their publications, with nine articles appearing there.

Best Publications

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

    Matthew D. Hirschey;Tadahiro Shimazu;Tadahiro Shimazu;Eric Goetzman;Enxuan Jing

  • A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

    In Hye Lee;Liu Cao;Raul Mostoslavsky;David B. Lombard

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • DNA Repair, Genome Stability, and Aging

    David B. Lombard;Katrin F. Chua;Raul Mostoslavsky;Sonia Franco

  • SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

    Jeongsoon Park;Yue Chen;Daniel X. Tishkoff;Chao Peng

  • Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

    Minjia Tan;Chao Peng;Kristin A. Anderson;Peter Chhoy

  • The first identification of lysine malonylation substrates and its regulatory enzyme

    Chao Peng;Zhike Lu;Zhongyu Xie;Zhongyi Cheng

  • The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

    Carlos Sebastián;Bernardette M. M. Zwaans;Dafne Magali Silberman;Dafne Magali Silberman;Melissa Gymrek

  • Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

    Yu Zhang;So Hee Kwon;Teppei Yamaguchi;Fabien Cubizolles

  • Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

    Gordon J. Freeman;Gary S. Gray;Claude D. Gimmi;David B. Lombard

  • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

    Enxuan Jing;Brice Emanuelli;Matthew D. Hirschey;Jeremie Boucher

  • Essential role of limiting telomeres in the pathogenesis of Werner syndrome.

    Sandy Chang;Asha S Multani;Noelia G Cabrera;Maria L Naylor

  • Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice

    Gordon J. Freeman;Frank Borriello;Richard J. Hodes;Hans Reiser

  • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

    Tadahiro Shimazu;Matthew D. Hirschey;Lan Hua;Kristin E. Dittenhafer-Reed

  • Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

    Zhongyu Xie;Di Zhang;Dongjun Chung;Dongjun Chung;Zhanyun Tang

  • The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

    Nagalingam R. Sundaresan;Prabhakaran Vasudevan;Lei Zhong;Gene Kim

  • Characterization of CTLA-4 structure and expression on human T cells

    T Lindsten;K P Lee;E S Harris;B Petryniak

  • Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice

    Sean Rooney;Jo Ann Sekiguchi;Chengming Zhu;Hwei Ling Cheng

  • H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

    Sonia Franco;Monica Gostissa;Shan Zha;David B. Lombard

Frequent Co-Authors

Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Raul Mostoslavsky
Raul Mostoslavsky Harvard University
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
Yingming Zhao
Yingming Zhao University of Chicago
Richard A. Miller
Richard A. Miller University of Michigan–Ann Arbor
Katrin F. Chua
Katrin F. Chua Stanford University
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Aviv Regev
Aviv Regev Genentech
Matthew D. Hirschey
Matthew D. Hirschey Duke University

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