2026 Costas A. Lyssiotis: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	83	3435	3162	1729	1553	653	34443

Overview

Costas A. Lyssiotis is affiliated with the University of Michigan-Ann Arbor in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions to medicine. The scientist's work spans molecular biology, cancer research, oncology, immunology, and genetics as subfields of study.

The main topics of their research include:

Cancer, Hypoxia, and Metabolism
Epigenetics and DNA Methylation
Pancreatic and Hepatic Oncology Research
Glioma Diagnosis and Treatment
Mitochondrial Function and Pathology
Cancer Research and Treatments
Immune cells in cancer

Significant recent papers authored or coauthored by Lyssiotis cover a range of topics in cancer biology and treatment:

"Cysteine depletion induces pancreatic tumor ferroptosis in mice," 2020, Science
"Pancreatic cancer: Advances and challenges," 2023, Cell
"Cancer SLC43A2 alters T cell methionine metabolism and histone methylation," 2020, Nature
"Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer," 2020, Nature Cancer
"Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis," 2020, Cancer Discovery

Frequent collaborators in Lyssiotis's research include:

Peter Sajjakulnukit
Anthony Andren
Daniel Wahl
Li Zhang
Marina Pasca di Magliano

Lyssiotis has published extensively in several venues, with a concentration of work appearing in:

bioRxiv (Cold Spring Harbor Laboratory)
Cancer Research
Neuro-Oncology
Nature Cancer
Nature Communications

Best Publications

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Haoqiang Ying;Alec C. Kimmelman;Costas A. Lyssiotis;Sujun Hua

1975
Citations
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

Jaekyoung Son;Costas A. Lyssiotis;Costas A. Lyssiotis;Haoqiang Ying;Xiaoxu Wang

1877
Citations
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

1241
Citations
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Andrea Viale;Piergiorgio Pettazzoni;Costas A. Lyssiotis;Haoqiang Ying

1190
Citations
A colorectal cancer classification system that associates cellular phenotype and responses to therapy

Anguraj Sadanandam;Costas A Lyssiotis;Costas A Lyssiotis;Krisztian Homicsko;Krisztian Homicsko;Eric A Collisson

1057
Citations
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Cristovão M. Sousa;Douglas E. Biancur;Xiaoxu Wang;Christopher J. Halbrook

967
Citations
Cysteine depletion induces pancreatic tumor ferroptosis in mice.

Michael A. Badgley;Daniel M. Kremer;H. Carlo Maurer;H. Carlo Maurer;Kathleen E. DelGiorno

923
Citations
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Weiwei Yang;Yanhua Zheng;Yan Xia;Haitao Ji

862
Citations
Metabolic Interactions in the Tumor Microenvironment

Costas A. Lyssiotis;Alec C. Kimmelman

726
Citations
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

Ng Shyh-Chang;Jason W. Locasale;Jason W. Locasale;Costas A. Lyssiotis;Costas A. Lyssiotis;Yuxiang Zheng

641
Citations
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.

Tomasz Maj;Wei Wang;Wei Wang;Joel Crespo;Hongjuan Zhang

611
Citations
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Kirsten L. Bryant;Clint A. Stalnecker;Daniel Zeitouni;Jennifer E. Klomp

578
Citations
A regenerative approach to the treatment of multiple sclerosis

Vishal A. Deshmukh;Virginie Tardif;Costas A. Lyssiotis;Chelsea C. Green

565
Citations
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Surendra K. Shukla;Vinee Purohit;Kamiya Mehla;Venugopal Gunda

545
Citations
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

Costas A. Lyssiotis;Ruth K. Foreman;Judith Staerk;Michael Garcia

463
Citations
Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Ashish Juvekar;Laura N. Burga;Hai Hu;Elaine P. Lunsford

462
Citations
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.

Yingjie Bian;Wei Li;Daniel M. Kremer;Peter Sajjakulnukit

398
Citations
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

Hai Hu;Ashish Juvekar;Costas A. Lyssiotis;Evan C. Lien

370
Citations
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer

Nina G. Steele;Eileen S. Carpenter;Samantha B. Kemp;Veerin R. Sirihorachai

343
Citations
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

Christopher J. Halbrook;Costas A. Lyssiotis

340
Citations