World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
77
Citations
19624
World Ranking
4822
National Ranking
2327

Medicine

D-Index
77
Citations
19649
World Ranking
18504
National Ranking
9221

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Maria G. Castro is affiliated with the University of Michigan-Ann Arbor in the United States. Their work spans medicine and biochemistry, genetics, and molecular biology, with significant contributions to glioma diagnosis and treatment, genetics, molecular biology, and immunology.

Their research fields include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, the main subfields of study are:

  • Genetics
  • Molecular Biology
  • Immunology
  • Oncology
  • Neurology

Key research topics addressed include:

  • Glioma Diagnosis and Treatment
  • Immune cells in cancer
  • Virus-based gene therapy research
  • Epigenetics and DNA Methylation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cancer, Hypoxia, and Metabolism
  • Immunotherapy and Immune Responses

Maria G. Castro has published extensively, with frequent appearances in journals such as:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Journal of Clinical Investigation

Recent notable papers include:

  • Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy, 2020, Nature Communications
  • Purine metabolism regulates DNA repair and therapy resistance in glioblastoma, 2020, Nature Communications
  • Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice, 2020, Journal of Clinical Investigation
  • Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy, 2022, ACS Nano
  • Current Approaches for Glioma Gene Therapy and Virotherapy, 2021, Frontiers in Molecular Neuroscience

Frequent co-authors collaborating with Maria G. Castro include:

  • Pedro R. Löwenstein
  • Syed Mohd Faisal
  • Andrea Comba
  • María L. Varela
  • Padma Kadiyala

Maria G. Castro was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • Consensus guidelines for the detection of immunogenic cell death

    Oliver Kepp;Laura Senovilla;Ilio Vitale;Erika Vacchelli

  • Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.

    R. A. Dewey;G. Morrissey;C. M. Cowsill;D. Stone

  • Platelets Mediate Cytotoxic T Lymphocyte-Induced Liver Damage.

    Matteo Iannacone;Giovanni Sitia;Masanori Isogawa;Patrizia Marchese

  • Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression

    Marianela Candolfi;Marianela Candolfi;James F. Curtin;James F. Curtin;W. Stephen Nichols;A. K.M.G. Muhammad

  • HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

    James F Curtin;James F Curtin;Naiyou Liu;Naiyou Liu;Marianela Candolfi;Marianela Candolfi;Weidong Xiong;Weidong Xiong

  • Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases.

    Clare E. Thomas;Gudrun Schiedner;Stefan Kochanek;Maria G. Castro

  • Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges

    Shyam Goverdhana;Mariana Puntel;Weidong Xiong;Jeffrey M Zirger

  • Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

    Jason V. Gregory;Padma Kadiyala;Robert Doherty;Melissa Cadena

  • Post-translational processing of proopiomelanocortin in the pituitary and in the brain

    Maria G. Castro;Ewan Morrison

  • Progress in gene therapy for neurological disorders

    Michele Simonato;Jean Bennett;Nicholas M. Boulis;Maria G. Castro

  • Current and future strategies for the treatment of malignant brain tumors

    M.G Castro;R Cowen;I.K Williamson;I.K Williamson;A David

  • ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

    Carl Koschmann;Anda-Alexandra Calinescu;Felipe J. Nunez;Alan Mackay

  • Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.

    Adrian E. Morelli;Adriana T. Larregina;Joseph Smith-Arica;Ricardo A. Dewey

  • Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions

    Pedro R. Lowenstein;Ronald J. Mandel;Wei Dong Xiong;Kurt Kroeger

  • IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.

    Felipe J. Núñez;Flor M. Mendez;Padma Kadiyala;Mahmoud S. Alghamri

  • Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain.

    Clare E. Thomas;Darren Birkett;Ijeoma Anozie;Maria G. Castro

  • Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity.

    A. Grande-Pérez;S. Sierra;M. G. Castro;M. G. Castro;M. G. Castro;E. Domingo

  • Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy.

    Neha Kamran;Padma Kadiyala;Meghna Saxena;Marianela Candolfi

  • Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.

    Evelyn Abordo-Adesida;Antonia Follenzi;Carlos Barcia;Sandra Sciascia

  • Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy

    Gregory J. Baker;Viveka Nand Yadav;Sebastien Motsch;Carl Koschmann

Frequent Co-Authors

Pedro R. Lowenstein
Pedro R. Lowenstein University of Michigan–Ann Arbor
David Klatzmann
David Klatzmann Sorbonne University
David Altshuler
David Altshuler Harvard University
Alexander V. Ljubimov
Alexander V. Ljubimov Cedars-Sinai Medical Center
James J. Moon
James J. Moon University of Michigan–Ann Arbor
Chris M. Preston
Chris M. Preston University of Glasgow
Alan K. Meeker
Alan K. Meeker Johns Hopkins University School of Medicine
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
Henry D. Appelman
Henry D. Appelman University of Michigan–Ann Arbor
Antoni Ribas
Antoni Ribas University of California, Los Angeles

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