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Stefan Kochanek

Stefan Kochanek

D-Index & Metrics

Molecular Biology

D-Index
59
Citations
14052
World Ranking
2012
National Ranking
139

Overview

Stefan Kochanek is affiliated with the University of Ulm in Germany. Their research spans several interconnected fields, focusing primarily on biochemical, genetic, and molecular biological aspects of medicine and disease. Kochanek has contributed extensively to topics including virus-based gene therapy, genetic neurodegenerative diseases, mitochondrial function and pathology, CAR-T cell therapy, viral infectious diseases and gene expression in insects, RNA interference and gene delivery, and muscle physiology and disorders.

Their publication record reflects work published in a variety of scientific venues, with frequent contributions to Viruses, Research Square, International Journal of Molecular Sciences, Human Gene Therapy, and Neurobiology of Disease.

Some of Stefan Kochanek's recent papers include:

  • Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia (2021, Blood)
  • Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging (2021, Cell Reports)
  • Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT) (2021, Research Square)
  • Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine (2022, eLife)
  • Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination (2022, npj Vaccines)

Kochanek frequently collaborates with other researchers, with notable co-authors including:

  • Lea Krutzke
  • Tatjana Engler
  • Manuel Seefelder
  • Ellen Allmendinger
  • Robin Nilson

Their research systematically addresses complex molecular and cellular mechanisms related to gene therapy, immune responses, and neurodegeneration. By integrating biochemical and genetic methods, their studies contribute to the understanding of both fundamental biological processes and translational medical applications.

Best Publications

  • Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

    Gudrun Schiedner;Núria Morral;Núria Morral;Robin J. Parks;Ying Wu

  • A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase

    S Kochanek;P R Clemens;K Mitani;H H Chen

  • An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

    M. A. Morsy;M. Gu;S. Motzel;Jing Zhao

  • Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

    Núria Morral;Wanda O’Neal;Karen Rice;Michele Leland

  • Adenovirus-mediated regulable target gene expression in vivo

    Mark M. Burcin;Gudrun Schiedner;Stefan Kochanek;Sophia Y. Tsai

  • Persistence in muscle of an adenoviral vector that lacks all viral genes

    Hsiao-Huei Chen;Lisa M. Mack;Robert Kelly;Marcia Ontell

  • Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector.

    K Mitani;F L Graham;C T Caskey;S Kochanek

  • Adenoviral vectors for gene transfer and therapy.

    Christoph Volpers;Stefan Kochanek;Stefan Kochanek

  • High Doses of a Helper-Dependent Adenoviral Vector Yield Supraphysiological Levels of α1-Antitrypsin with Negligible Toxicity

    Núria Morral;Robin J. Parks;Heshan Zhou;Claire Langston

  • Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases.

    Clare E. Thomas;Gudrun Schiedner;Stefan Kochanek;Maria G. Castro

  • Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide.

    Florian Kreppel;Stefan Kochanek

  • Frequency and Stability of Chromosomal Integration of Adenovirus Vectors

    Airi Harui;Shinobu Suzuki;Stefan Kochanek;Kohnosuke Mitani

  • Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production.

    Gudrun Schiedner;Sabine Hertel;Stefan Kochanek

  • Insights in ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT).

    Andreas Greinacher;Kathleen Selleng;Raghavendra Palankar;Jan Wesche

  • In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes.

    P R Clemens;S Kochanek;Y Sunada;S Chan

  • High-capacity adenoviral vectors for gene transfer and somatic gene therapy.

    Stefan Kochanek

  • DNA methylation in the Alu sequences of diploid and haploid primary human cells

    S Kochanek;D Renz;W Doerfler

  • Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors

    Lucio Pastore;Nuria Morral;Heshan Zhou;Racel Garcia

  • High-capacity 'gutless' adenoviral vectors.

    Kochanek S;Schiedner G;Volpers C

  • Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors.

    Gudrun Schiedner;Sabine Hertel;Marion Johnston;Volker Dries

Frequent Co-Authors

Walter Doerfler
Walter Doerfler University of Cologne
Jesús Prieto
Jesús Prieto University of Navarra
Frank L. Graham
Frank L. Graham McMaster University
Nico van Rooijen
Nico van Rooijen Vrije Universiteit Amsterdam
Meinhard Wlaschek
Meinhard Wlaschek University of Ulm
David Lillicrap
David Lillicrap Queen's University
Arthur L. Beaudet
Arthur L. Beaudet Baylor College of Medicine
Brian D. Brown
Brian D. Brown Icahn School of Medicine at Mount Sinai
Robin J. Parks
Robin J. Parks Ottawa Hospital
Klaus Addicks
Klaus Addicks University of Cologne

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