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Immunology
Netherlands
2026
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Medicine
Netherlands
2023

D-Index & Metrics

Immunology

D-Index
158
Citations
92984
World Ranking
89
National Ranking
3

Medicine

D-Index
158
Citations
93134
World Ranking
857
National Ranking
33

Research.com Recognitions

  • 2026 - Research.com Immunology in Netherlands Leader Award
  • 2025 - Research.com Immunology in Netherlands Leader Award
  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2022 - Research.com Immunology in Netherlands Leader Award

Overview

Nico van Rooijen is affiliated with the Vrije Universiteit Amsterdam in the Netherlands. Their research spans several interconnected areas within medicine, including epidemiology, molecular biology, oncology, neurology, and immunology. This multidisciplinary approach is reflected in a variety of research topics focused primarily on liver disease diagnosis and treatment, immune cell function and interaction, metabolism related to diabetes and cancer, pancreatic function and diabetes, peroxisome proliferator-activated receptors, drug transport and resistance mechanisms, as well as neuroinflammation and neurodegeneration mechanisms.

Their recent publications illustrate a focus on both cellular mechanisms and disease pathophysiology. These include:

  • Liver Fetuin-A at Initiation of Insulin Resistance, 2022, published in Metabolites
  • Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis, 2020, published in International Journal of Molecular Sciences
  • Microglia/Macrophages and CD4+CD25+ T Cells Enhance the Ability of Injury-Activated Lymphocytes to Reduce Traumatic Optic Neuropathy In Vitro, 2021, published in Frontiers in Immunology
  • Kupffer Cell and Interleukin-12-Dependent Loss of Natural Killer T Cells in Hepatosteatosis, 2020, published in UNC Libraries
  • Control of TH17 Cells Occurs in the Small Intestine, 2020, published in UNC Libraries

Frequent coauthors include Nicolas Lanthier, Valérie Lebrun, Olivier Molendi-Coste, Isabelle Leclercq, and Rike Schulte, indicating collaboration across several aspects of biomedical research. The publication venues associated with their work demonstrate varied interdisciplinary engagement, with multiple contributions to UNC Libraries, Metabolites, International Journal of Molecular Sciences, and Frontiers in Immunology.

Nico van Rooijen's work primarily contributes to the field of medicine, with a balanced focus on both clinical and molecular perspectives. The subfields of study, especially epidemiology and molecular biology, align with their exploration of disease mechanisms and immune system interactions. The presence of neuroinflammation and neurodegeneration as research topics suggests additional interest in neurological disease pathways alongside metabolic and oncological processes.

Overall, van Rooijen's research portfolio addresses complex biological interactions underlying liver and immune-related diseases, diabetes, cancer, and neurological conditions. The diversity of topics and collaborative network emphasizes an integrative scientific inquiry into both fundamental mechanisms and applied medical challenges.

Best Publications

  • Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

    Daigo Hashimoto;Andrew Chow;Andrew Chow;Clara Noizat;Clara Noizat;Pearline Teo

  • Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

    Ludovic Arnold;Adeline Henry;Françoise Poron;Yasmine Baba-Amer

  • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

    Ravindra Majeti;Mark P. Chao;Ash A. Alizadeh;Wendy W. Pang

  • CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

    Siddhartha Jaiswal;Catriona H.M. Jamieson;Wendy W. Pang;Christopher Y. Park

  • Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

    Stephen J. Jenkins;Dominik Ruckerl;Peter C. Cook;Lucy H. Jones

  • Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

    Frank Tacke;David Alvarez;Theodore J. Kaplan;Claudia Jakubzick

  • Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response.

    Cord Sunderkötter;Tatjana Nikolic;Marilyn J. Dillon;Nico van Rooijen

  • Local proliferation dominates lesional macrophage accumulation in atherosclerosis

    Clinton S Robbins;Ingo Hilgendorf;Georg F Weber;Igor Theurl

  • Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

    Agnes Machnik;Wolfgang Neuhofer;Jonathan Jantsch;Anke Dahlmann

  • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

    Prakash Ramachandran;Antonella Pellicoro;Madeleine A. Vernon;Luke Boulter

  • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

    Tobias Junt;E. Ashley Moseman;Matteo Iannacone;Steffen Massberg

  • Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

    Christian Fischer;Bart Jonckx;Massimiliano Mazzone;Serena Zacchigna

  • Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

    Andrew Chow;Daniel Lucas;Daniel Lucas;Andrés Hidalgo;Andrés Hidalgo;Simón Méndez-Ferrer;Simón Méndez-Ferrer

  • Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

    Giovanni Germano;Roberta Frapolli;Cristina Belgiovine;Achille Anselmo

  • Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.

    Katia De Filippo;Anne Dudeck;Mike Hasenberg;Emma Nye

  • Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

    Ingrid G. Winkler;Natalie A. Sims;Allison R. Pettit;Valérie Barbier

  • Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

    Claudia Jakubzick;Claudia Jakubzick;Emmanuel L. Gautier;Sophie L. Gibbings;Dorothy K. Sojka

  • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis.

    Chantal A. Rivera;Patrick Adegboyega;Nico van Rooijen;Arlene Tagalicud

  • Microglia promote the death of developing Purkinje cells.

    José Luis Marı́n-Teva;Isabelle Dusart;Catherine Colin;Annie Gervais

  • Chitin induces accumulation in tissue of innate immune cells associated with allergy

    Tiffany A. Reese;Hong-Erh Liang;AndrewN M. Tager;Andrew D. Luster

  • IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

    Mariola Kurowska-Stolarska;Bartosz Stolarski;Peter Kewin;Grace Murphy

  • MHC class II–dependent basophil–CD4 + T cell interactions promote T H 2 cytokine–dependent immunity

    Jacqueline G Perrigoue;Steven A Saenz;Mark C Siracusa;Eric J Allenspach

Frequent Co-Authors

Pierre Bruhns
Pierre Bruhns Université Paris Cité
Stuart A. Nicklin
Stuart A. Nicklin University of Glasgow
Qi Cui
Qi Cui Chinese University of Hong Kong
Stefan Kochanek
Stefan Kochanek University of Ulm
Claudia Jakubzick
Claudia Jakubzick Dartmouth College
Miriam Merad
Miriam Merad Icahn School of Medicine at Mount Sinai
Simon N. Waddington
Simon N. Waddington University College London
Paul S. Frenette
Paul S. Frenette Albert Einstein College of Medicine
Masato Tanaka
Masato Tanaka Tokyo University of Pharmacy and Life Sciences
Frank Tacke
Frank Tacke Charité - University Medicine Berlin

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