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Immunology

D-Index
46
Citations
10479
World Ranking
4590
National Ranking
2069

Overview

George S. Yap is affiliated with Rutgers, The State University of New Jersey in the United States and conducts research primarily within the fields of Medicine and Immunology and Microbiology. Their work spans several interconnected subfields including Parasitology, Immunology, Epidemiology, Physiology, and Molecular Biology.

The scientist's research contributions prominently focus on a range of topics such as Toxoplasma gondii Research Studies, Parasitic Infections and Diagnostics, GDF15 and Related Biomarkers, Adenosine and Purinergic Signaling, Neuroinflammation and Neurodegeneration Mechanisms, Cytomegalovirus and herpesvirus research, as well as Macrophage Migration Inhibitory Factor.

Several recent notable publications authored or coauthored by George S. Yap include:

  • Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine (2020, Immunity)
  • Emerging Roles of Growth Differentiation Factor 15 in Immunoregulation and Pathogenesis (2023, The Journal of Immunology)
  • Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration (2020, JCI Insight)
  • Trichinella spiralis-induced mastocytosis and erythropoiesis are simultaneously supported by a bipotent mast cell/erythrocyte precursor cell (2020, PLoS Pathogens)
  • Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling in intestinal epithelial cells (2022, Cell Reports)

George S. Yap frequently collaborates with a number of coauthors, including:

  • Yanlin Zhao
  • Jojo Reyes
  • Azadeh Nasuhidehnavi
  • Darine W. El-Naccache
  • William C. Gause

The scientist's research has appeared regularly in several publication venues, most notably:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • The Journal of Immunology
  • Trends in Parasitology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunity

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.

    Stanimir Ivanov;Ana Maria Dragoi;Xin Wang;Corrado Dallacosta

  • Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

    Tanya M. Scharton-Kersten;George Yap;Jeanne Magram;Alan Sher

  • Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

    Edward M. Schaeffer;Jayanta Debnath;George Yap;Daniel McVicar

  • Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

    Yun M. Ling;Michael H. Shaw;Carol Ayala;Isabelle Coppens

  • Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

    Carmen M. Collazo;George S. Yap;Gregory D. Sempowski;Kimberly C. Lusby;Kimberly C. Lusby

  • Cutting Edge: IL-12 Is Required for the Maintenance of IFN-γ Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen, Toxoplasma gondii

    George Yap;Michael Pesin;Alan Sher

  • Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP

    Gregory A. Taylor;Carmen M. Collazo;George S. Yap;Khuong Nguyen

  • Effector Cells of Both Nonhemopoietic and Hemopoietic Origin Are Required for Interferon (IFN)-γ– and Tumor Necrosis Factor (TNF)-α–dependent Host Resistance to the Intracellular Pathogen, Toxoplasma gondii

    George S. Yap;Alan Sher

  • Effect of helminth-induced immunity on infections with microbial pathogens

    Padmini Salgame;George S Yap;William C Gause

  • Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

    Michael J. Czar;Ellen N. Kersh;Lilia A. Mijares;Gibson Lanier

  • IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii

    Yasuhiro Suzuki;Yasuhiro Suzuki;Alan Sher;George Yap;Daniel Park

  • Innate cell communication kick-starts pathogen-specific immunity.

    Amariliz Rivera;Mark C Siracusa;George S Yap;William C Gause

  • Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function.

    George S. Yap;Alan Sher

  • Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses

    Taro Fukao;David M. Frucht;George Yap;Massimo Gadina

  • Paneth Cell Multipotency Induced by Notch Activation following Injury

    Shiyan Yu;Kevin Tong;Yanlin Zhao;Iyshwarya Balasubramanian

  • CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

    Dragana Jankovic;Allen W. Cheever;Marika C. Kullberg;Thomas A. Wynn

  • Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine

    Shiyan Yu;Iyshwarya Balasubramanian;Daniel Laubitz;Kevin Tong

  • Mutation of Tec family kinases alters T helper cell differentiation.

    Edward M. Schaeffer;George S. Yap;George S. Yap;Carol M. Lewis;Michael J. Czar

  • Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.

    E Y Denkers;G Yap;T Scharton-Kersten;H Charest

  • Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology.

    Caetano Reis e Sousa;George Yap;Oliver Schulz;Neil Rogers

  • Decreased Resistance of TNF Receptor p55- and p75-Deficient Mice to Chronic Toxoplasmosis Despite Normal Activation of Inducible Nitric Oxide Synthase In Vivo

    George S. Yap;Tanya Scharton-Kersten;Hugues Charest;Alan Sher

  • A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA Running title: Mechanism of TLR9 activation

    Wen-Ming Chu;Giovanni Sitia;George S. Yap;Yinsheng Wan

Frequent Co-Authors

Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Dragana Jankovic
Dragana Jankovic National Institute of Allergy and Infectious Diseases
Patricia Caspar
Patricia Caspar National Institute of Allergy and Infectious Diseases
Allen W. Cheever
Allen W. Cheever National Institutes of Health
William C. Gause
William C. Gause Rutgers, The State University of New Jersey
Gregory A. Taylor
Gregory A. Taylor Duke University
Sara Hieny
Sara Hieny National Institute of Allergy and Infectious Diseases
Yasuhiro Suzuki
Yasuhiro Suzuki University of Kentucky
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais
Hugues Charest
Hugues Charest University of Montreal

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