World's Best Scientists 2026 revealed!
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Microbiology
USA
2026

D-Index & Metrics

Microbiology

D-Index
126
Citations
44602
World Ranking
101
National Ranking
51

Research.com Recognitions

  • 2026 - Research.com Microbiology in United States Leader Award
  • 2025 - Research.com Microbiology in United States Leader Award
  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2017 - Member of the National Academy of Sciences

Overview

L. David Sibley is affiliated with Washington University in St. Louis in the United States. Their research primarily focuses on the fields of Immunology and Microbiology, with substantial contributions also made in Medicine. Within these domains, their work spans several subfields, including Parasitology, Epidemiology, Infectious Diseases, Immunology, and Cell Biology.

The scientist has explored numerous topics, concentrating particularly on Toxoplasma gondii research studies and parasitic infections and diagnostics. Additional areas of interest include cytomegalovirus and herpesvirus research, amoebic infections and treatments, autophagy in disease and therapy, interferon and immune responses, and research related to Clostridium difficile and Clostridium perfringens.

Some of the recent papers authored or co-authored by L. David Sibley include:

  • Toxoplasma gondii infection and its implications within the central nervous system, 2021, Nature Reviews Microbiology
  • The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii, 2022, Nature Communications
  • Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis, 2021, Cell Host & Microbe
  • Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins, 2021, Nature Communications
  • The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments, 2023, Nature Communications

The scientist has frequently published in several academic venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory) with 21 publications
  • mBio, 10 publications
  • Nature Communications, 9 publications
  • Proceedings of the National Academy of Sciences, 3 publications
  • ACS Infectious Diseases, 3 publications

Collaboration has been an important component of their work, with frequent coauthors including Yong Fu, Rui Xu, Lisa J. Funkhouser-Jones, Thaddeus S. Stappenbeck, and William H. Witola.

L. David Sibley has been recognized by professional organizations, receiving the fellowship of the American Association for the Advancement of Science (AAAS) in 2018 and being named a member of the National Academy of Sciences in 2017.

Best Publications

  • Virulent strains of Toxoplasma gondii comprise a single clonal lineage

    L. David Sibley;L. David Sibley;John C. Boothroyd

  • Toxoplasma Invasion of Mammalian Cells Is Powered by the Actin Cytoskeleton of the Parasite

    Janice M Dobrowolski;L.David Sibley

  • Polymorphic Secreted Kinases Are Key Virulence Factors in Toxoplasmosis

    Jeroen Saeij;J. P. Boyle;S. Coller;S. Taylor

  • Cytoskeleton of Apicomplexan Parasites

    Naomi S. Morrissette;L. David Sibley

  • Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

    Bang Shen;Kevin M. Brown;Tobie D. Lee;L. David Sibley

  • Modulation of innate immunity by Toxoplasma gondii virulence effectors

    Christopher A. Hunter;L. David Sibley

  • A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.

    S. Taylor;A. Barragan;A. Barragan;C. Su;C. Su;B. Fux

  • Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines.

    Dana G. Mordue;Fernando Monroy;Marie La Regina;Charles A. Dinarello

  • Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii.

    Ildiko R. Dunay;Renato A. DaMatta;Blima Fux;Rachel Presti

  • Compensatory dendritic cell development mediated by BATF–IRF interactions

    Roxane Tussiwand;Wan-Ling Lee;Theresa L. Murphy;Mona Mashayekhi

  • Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.

    Zijiang Zhao;Blima Fux;Megan Goodwin;Ildiko R. Dunay

  • CD8α+ dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites

    Mona Mashayekhi;Michelle M. Sandau;Ildiko R. Dunay;Eva M. Frickel

  • Secretion of micronemal proteins is associated with toxoplasma invasion of host cells.

    Vern B. Carruthers;Olivia K. Giddings;L. David Sibley

  • Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii.

    V B Carruthers;L D Sibley

  • Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages

    Chunlei Su;Asis Khan;Peng Zhou;Debashree Majumdar

  • Recent expansion of Toxoplasma through enhanced oral transmission.

    C. Su;D. Evans;R. H. Cole;J. C. Kissinger

  • Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites.

    Travis J. Jewett;L.David Sibley

  • Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole.

    Sebastian Håkansson;Audra J. Charron;L.David Sibley

  • Invasion of Toxoplasma gondii occurs by active penetration of the host cell

    J.H. Morisaki;J.E. Heuser;L.D. Sibley

  • Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii

    Michael S. Behnke;Michael S. Behnke;John C. Wootton;Margaret M. Lehmann;Josh B. Radke;Josh B. Radke

  • Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

    Sebastian Lourido;Joel Shuman;Chao Zhang;Kevan M. Shokat

Frequent Co-Authors

Jitender P. Dubey
Jitender P. Dubey Agricultural Research Service
Wandy L. Beatty
Wandy L. Beatty Washington University in St. Louis
John C. Boothroyd
John C. Boothroyd Stanford University
Chunlei Su
Chunlei Su University of Tennessee at Knoxville
Kevin M. Brown
Kevin M. Brown National Institutes of Health
Vern B. Carruthers
Vern B. Carruthers University of Michigan–Ann Arbor
David S. Roos
David S. Roos University of Pennsylvania
Kenneth M. Murphy
Kenneth M. Murphy Washington University in St. Louis
Marco Colonna
Marco Colonna Washington University in St. Louis

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