Juan F. Martín

Overview

Best Publications

• Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

  Marco A. Van Den Berg;Richard Albang;Kaj Albermann;Jonathan H. Badger

  554
  Citations

• The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.

  B Díez;S Gutiérrez;J L Barredo;P van Solingen

  322
  Citations

• Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story.

  Juan F. Martín

  300
  Citations

• Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains.

  S Gutiérrez;B Díez;E Montenegro;J F Martín

  250
  Citations

• The dynamic architecture of the metabolic switch in Streptomyces coelicolor

  Kay Nieselt;Florian Battke;Alexander Herbig;Per Bruheim;Per Bruheim

  206
  Citations

• A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

  Jesús F Aparicio;Roberto Fouces;Marta V Mendes;Noemı́ Olivera

  201
  Citations

• A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.

  F J Pérez-Llarena;P Liras;A Rodríguez-García;J F Martín

  199
  Citations

• The production of cephalosporin C by Acremonium chrysogenum is improved by the intracellular expression of a bacterial hemoglobin.

  J A DeModena;S Gutiérrez;J Velasco;F J Fernández

  197
  Citations

• High–Frequency Transformation of Penicillium Chrysogenum

  J. M. Cantoral;B. Díez;J. L. Barredo;E. Alvarez

  195
  Citations

• The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.

  Katarina Kosalková;Carlos García-Estrada;Ricardo V. Ullán;Ramiro P. Godio

  193
  Citations

• Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.

  Filomena R. Ramos;Manuel J. López-Nieto;Juan F. Martín

  186
  Citations

• Binding of PhoP to promoters of phosphate-regulated genes in Streptomyces coelicolor: identification of PHO boxes

  Alberto Sola-Landa;Antonio Rodríguez-García;Etelvina Franco-Domínguez;Juan F. Martín

  178
  Citations

• Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-aid-acyltransferase gene of Penicillium chrysogenum

  J.L. Barredo;P. van Solingen;B. Díez;E. Alvarez

  176
  Citations

• PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

  Nuria Antón;Javier Santos-Aberturas;Marta V. Mendes;Susana M. Guerra

  168
  Citations

• Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

  Nuria Antón;Marta V. Mendes;Juan F. Martín;Jesús F. Aparicio

  167
  Citations

• The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

  Jesús F. Aparicio;Angel J. Colina;Elvira Ceballos;Juan F. Martı́n

  166
  Citations

• Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase

  Mónica Lamas-Maceiras;Inmaculada Vaca;Esther Rodríguez;Javier Casqueiro

  165
  Citations

• Proteome Analysis of the Penicillin Producer Penicillium chrysogenum: CHARACTERIZATION OF PROTEIN CHANGES DURING THE INDUSTRIAL STRAIN IMPROVEMENT*

  Mohammad-Saeid Jami;Carlos Barreiro;Carlos García-Estrada;Juan Francisco Martín

  165
  Citations

• The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis

  Marta V. Mendes;Sedef Tunca;Nuria Antón;Eliseo Recio

  165
  Citations

• Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription.

  Fernando Santos-Beneit;Antonio Rodríguez-García;Alberto Sola-Landa;Juan F. Martín

  162
  Citations

• Characterization of an Endogenous Plasmid and Development of Cloning Vectors and a Transformation System in Brevibacterium lactofermentum

  Ramón Santamaría;José A. Gil;Juan M. Mesas;Juan F. Martín

  160
  Citations

• The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum

  J. J. R. Coque;J. F. Martin;J. G. Calzada;P. Liras

  158
  Citations

• Genome‐wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a ΔphoP mutant

  Antonio Rodríguez-García;Carlos Barreiro;Fernando Santos-Beneit;Alberto Sola-Landa

  156
  Citations