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Gilles P. van Wezel

Gilles P. van Wezel

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
23588
World Ranking
6543
National Ranking
168

Overview

Gilles P. van Wezel is affiliated with Leiden University in the Netherlands and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with additional work in medicine. Their research spans multiple subfields including molecular biology, pharmacology, plant science, organic chemistry, and biotechnology.

The scientist's research topics cover a range of areas primarily focused on microbial natural products and biosynthesis. Other main subjects of study include genomics and phylogenetic studies, RNA and protein synthesis mechanisms, plant-microbe interactions and immunity, bacterial genetics and biotechnology, fungal biology and applications, and carbohydrate chemistry and synthesis.

Their recent publications demonstrate involvement in advancing computational tools and understanding microbial natural product discovery. Notable papers include:

  • antiSMASH 6.0: improving cluster detection and comparison capabilities, 2021, Nucleic Acids Research
  • antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation, 2023, Nucleic Acids Research
  • New developments in RiPP discovery, enzymology and engineering, 2020, Natural Product Reports
  • Ecology and genomics of Actinobacteria: new concepts for natural product discovery, 2020, Nature Reviews Microbiology
  • Artificial intelligence for natural product drug discovery, 2023, Nature Reviews Drug Discovery

They have worked frequently with a core group of co-authors, including Somayah S. Elsayed, Marnix H. Medema, Chao Du, Dennis Claessen, and Hannah E. Augustijn.

Their work is published in a variety of scientific journals and platforms, with repeated contributions to bioRxiv (Cold Spring Harbor Laboratory), PLoS Biology, Nucleic Acids Research, Natural Product Reports, and mSystems. These venues reflect the interdisciplinary nature of their research efforts and collaboration patterns.

Best Publications

  • Taxonomy, Physiology, and Natural Products of Actinobacteria

    Essaid Ait Barka;Parul Vatsa;Lisa Sanchez;Nathalie Gaveau-Vaillant

  • antiSMASH 6.0: improving cluster detection and comparison capabilities.

    Kai Blin;Simon Shaw;Alexander M Kloosterman;Zach Charlop-Powers

  • Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria.

    Essaid Ait Barka;Parul Vatsa;Lisa Sanchez;Nathalie Gaveau-Vaillant

  • Objective comparison of particle tracking methods

    Nicolas Chenouard;Ihor Smal;Fabrice de Chaumont;Martin Maška;Martin Maška

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

    Víctor J. Carrión;Juan Perez-Jaramillo;Viviane Cordovez;Vittorio Tracanna

  • New developments in RiPP discovery, enzymology and engineering

    Manuel Montalbán-López;Thomas A Scott;Sangeetha Ramesh;Imran R Rahman

  • Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies.

    Dennis Claessen;Daniel E. Rozen;Oscar P. Kuipers;Lotte Søgaard-Andersen

  • Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

    Sébastien Rigali;Sébastien Rigali;Fritz Titgemeyer;Sharief Barends;Suzanne Mulder

  • The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

    Gilles P. van Wezel;Kenneth J. McDowall

  • Chemical ecology of antibiotic production by actinomycetes

    Anne van der Meij;Sarah F. Worsley;Matthew I. Hutchings;Gilles P. van Wezel

  • Ecology and genomics of Actinobacteria: new concepts for natural product discovery.

    Doris A. van Bergeijk;Barbara R. Terlouw;Marnix H. Medema;Gilles P. van Wezel

  • The Square-Planar Cytotoxic [CuII(pyrimol)Cl] Complex Acts as an Efficient DNA Cleaver without Reductant

    Palanisamy Uma Maheswari;Sudeshna Roy;Hans Den Dulk;Sharief Barends

  • Socially mediated induction and suppression of antibiosis during bacterial coexistence

    Monica I. Abrudan;Monica I. Abrudan;Fokko Smakman;Ard Jan Grimbergen;Ard Jan Grimbergen;Sanne Westhoff

  • Diversity and functions of volatile organic compounds produced by Streptomyces from a disease-suppressive soil.

    Viviane Cordovez;Victor J. Carrion;Desalegn W. Etalo;Roland Mumm

  • Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces

    Joost Willemse;Jan Willem Borst;Ellen de Waal;Ton Bisseling

  • Triggers and cues that activate antibiotic production by actinomycetes.

    Hua Zhu;Stephanie K. Sandiford;Gilles P. van Wezel

  • Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era.

    Helga U. van der Heul;Bohdan L. Bilyk;Kenneth J. McDowall;Ryan F. Seipke

  • ssgA is essential for sporulation of Streptomyces coelicolor A3(2) and affects hyphal development by stimulating septum formation.

    Gilles P. van Wezel;Jannes van der Meulen;Shinichi Kawamoto;Ruud G. M. Luiten

  • Unlocking Streptomyces spp. for use as sustainable industrial production platforms by morphological engineering

    Gilles P. van Wezel;Preben Krabben;Bjørn A. Traag;Bart J. F. Keijser

Frequent Co-Authors

Young Hae Choi
Young Hae Choi Leiden University
Marnix H. Medema
Marnix H. Medema Wageningen University & Research
Jos M. Raaijmakers
Jos M. Raaijmakers Leiden University
Jan Pieter Abrahams
Jan Pieter Abrahams Paul Scherrer Institute
Herman S. Overkleeft
Herman S. Overkleeft Leiden University
Jan Reedijk
Jan Reedijk Leiden University
Mervyn J. Bibb
Mervyn J. Bibb John Innes Centre
Thomas Hankemeier
Thomas Hankemeier Leiden University
Abraham J. Koster
Abraham J. Koster Leiden University Medical Center
Adam Godzik
Adam Godzik University of California, Riverside

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