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D-Index
67
Citations
15190
World Ranking
8256
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3734

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Vern B. Carruthers is a researcher affiliated with the University of Michigan-Ann Arbor in the United States. Their work broadly spans the fields of Immunology and Microbiology as well as Medicine, with significant contributions to parasitology, epidemiology, and molecular biology among other subfields.

Their research focuses intensively on parasitic infections and related mechanisms, especially involving Toxoplasma gondii. This is reflected in extensive publication topics that include Toxoplasma gondii research studies, herpesvirus infections and treatments, cytomegalovirus and herpesvirus research, autophagy in disease and therapy, mosquito-borne diseases and control, parasitic infections and diagnostics, and rabies epidemiology and control.

Recent papers authored or co-authored by Vern B. Carruthers include:

  • Stable endocytic structures navigate the complex pellicle of apicomplexan parasites (2023, Nature Communications)
  • Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins (2021, PLoS Pathogens)
  • Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts (2021, eLife)
  • The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii (2023, Nature Communications)
  • The multifaceted interactions between pathogens and host ESCRT machinery (2023, PLoS Pathogens)

Vern B. Carruthers frequently publishes in journals and platforms such as bioRxiv (Cold Spring Harbor Laboratory), mSphere, Nature Communications, PLoS Pathogens, and mBio. These venues have hosted a substantial portion of their work, demonstrating a consistent engagement with microbiology and infectious disease research communities.

Their collaborations often involve a core group of researchers, including Manlio Di Cristina, Tracey L. Schultz, Sebastian Lourido, Yolanda Rivera-Cuevas, and Geetha Kannan. These co-authors have contributed to a significant number of joint publications, highlighting a collaborative research approach.

An award recognizing Vern B. Carruthers' contributions is the prestigious Fellow of the American Association for the Advancement of Science (AAAS), awarded in 2019.

Best Publications

  • SEQUENTIAL PROTEIN SECRETION FROM THREE DISTINCT ORGANELLES OF TOXOPLASMA GONDII ACCOMPANIES INVASION OF HUMAN FIBROBLASTS

    V B Carruthers;L D Sibley

  • A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.

    Saima M. Sidik;Diego Huet;Suresh M. Ganesan;My Hang Huynh

  • Tagging of Endogenous Genes in a Toxoplasma gondii Strain Lacking Ku80

    My Hang Huynh;Vern B. Carruthers

  • Secretion of micronemal proteins is associated with toxoplasma invasion of host cells.

    Vern B. Carruthers;Olivia K. Giddings;L. David Sibley

  • Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii.

    V B Carruthers;L D Sibley

  • Pulling together: an integrated model of Toxoplasma cell invasion

    Vern Carruthers;John C Boothroyd

  • Effects of Toxoplasma gondii Infection on the Brain

    Vern B. Carruthers;Yasuhiro Suzuki

  • Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

    Björn F. C. Kafsack;Janethe D. O. Pena;Isabelle Coppens;Sandeep Ravindran

  • Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2–M2AP adhesive protein complex

    My Hang Huynh;Karen E. Rabenau;Jill M. Harper;Wandy L. Beatty

  • Host cell invasion by the opportunistic pathogen Toxoplasma gondii.

    Vern B. Carruthers

  • Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii.

    Janice M. Dobrowolski;Vern B. Carruthers;L. David Sibley

  • Microneme Proteins in Apicomplexans

    Vern B. Carruthers;Fiona M. Tomley

  • Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

    Julio Aliberti;Jesus G. Valenzuela;Vern B. Carruthers;Sara Hieny

  • Toxoplasma MIC2 Is a Major Determinant of Invasion and Virulence

    My Hang Huynh;Vern B. Carruthers

  • A Novel Family of Toxoplasma IMC Proteins Displays a Hierarchical Organization and Functions in Coordinating Parasite Division

    Josh R. Beck;Imilce A. Rodriguez-Fernandez;Jessica Cruz de Leon;My Hang Huynh

  • Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2

    Kiew Lian Wan;Vern B. Carruthers;L. David Sibley;James W. Ajioka

  • The Toxoplasma Adhesive Protein MIC2 Is Proteolytically Processed at Multiple Sites by Two Parasite-derived Proteases

    Vern B. Carruthers;Vern B. Carruthers;Gale D. Sherman;L. David Sibley

  • Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge in Toxoplasma gondii.

    V. B. Carruthers;S. N. J. Moreno;L. D. Sibley

  • A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters.

    Markus Meissner;Matthias Reiss;Nicola Viebig;Vern B. Carruthers

  • A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

    Saima M. Sidik;Diego Huet;My-Hang Huynh;Prathapan Thiru

Frequent Co-Authors

Isabelle Coppens
Isabelle Coppens Johns Hopkins University
L. David Sibley
L. David Sibley Washington University in St. Louis
George A. M. Cross
George A. M. Cross Rockefeller University
Michael J. Blackman
Michael J. Blackman London School of Hygiene & Tropical Medicine
Kami Kim
Kami Kim University of South Florida
Matthew Bogyo
Matthew Bogyo Stanford University
Ethan A. Merritt
Ethan A. Merritt University of Washington
Fiona M. Tomley
Fiona M. Tomley Royal Veterinary College
Robert H. Gilman
Robert H. Gilman Johns Hopkins University
David S. Roos
David S. Roos University of Pennsylvania

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