World's Best Scientists 2026 revealed!
Francis Ka-Ming Chan

Francis Ka-Ming Chan

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
29735
World Ranking
14135
National Ranking
5959

Overview

Francis Ka-Ming Chan is based at Duke University in the United States. Their research activities are primarily centered around biochemistry, genetics, molecular biology, and medicine, with particular emphasis on molecular biology and immunology. Chan's work explores a variety of interconnected topics such as cell death mechanisms and regulation, phagocytosis and immune regulation, gut microbiota and health, interferon and immune responses, as well as inflammasome and immune disorders.

The scientist has contributed to the understanding of cell death and immune processes through numerous research papers. Notable recent publications include:

  • Apoptotic cell death in disease-Current understanding of the NCCD 2023 (2023), published in Cell Death and Differentiation
  • A second-generation M1-polarized CAR macrophage with antitumor efficacy (2023), published in Nature Immunology
  • A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation (2021), published in Immunity
  • Sweet modification and regulation of death receptor signalling pathway (2021), published in The Journal of Biochemistry
  • Regulatory mechanisms of RIPK1 in cell death and inflammation (2020), published in Seminars in Cell and Developmental Biology

The scientist frequently collaborates with several co-authors, including Siew C. Ng, Jingwan Zhang, Kenta Moriwaki, Jessica Ching, and Pui K. Cheong. Many of these collaborations have resulted in multiple publications, highlighting ongoing partnerships in related fields.

Francis Ka-Ming Chan's research has appeared primarily in journals such as:

  • Gastroenterology (16 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Nature Immunology (2 publications)
  • Immunity (2 publications)
  • Cell Death and Differentiation (1 publication)

The main subfields of study encompass molecular biology, immunology, oncology, genetics, and infectious diseases. This diverse research scope aligns with their main topics of interest, which include investigating NF-κB signaling pathways and exploring poxvirus research and outbreaks alongside immune-related regulatory mechanisms.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

    Young Sik Cho;Sreerupa Challa;David Moquin;Ryan Genga

  • The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

    Jixi Li;Thomas McQuade;Ansgar B. Siemer;Johanna Napetschnig

  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

    Francis Ka-Ming Chan;Hyung J. Chun;Lixin Zheng;Richard M. Siegel

  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.

    M Lenardo;K M Chan;F Hornung;H McFarland

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

    Richard M. Siegel;John K. Frederiksen;David A. Zacharias;Francis Ka Ming Chan

  • Detection of necrosis by release of lactate dehydrogenase activity.

    Francis Ka Ming Chan;Kenta Moriwaki;Maria Jose de Rosa

  • Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

    Jin Wang;Lixin Zheng;Adrian Lobito;Francis Ka Ming Chan

  • RIP3 induces apoptosis independent of pronecrotic kinase activity.

    Pratyusha Mandal;Scott B. Berger;Sirika Pillay;Kenta Moriwaki

  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.

    Francis Ka Ming Chan;Francis Ka Ming Chan;Joanna L. Shisler;Jacqueline G. Bixby;Martin Felices

  • Necroptosis: Mechanisms and Relevance to Disease

    Lorenzo Galluzzi;Oliver Kepp;Francis Ka-Ming Chan;Guido Kroemer

  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.

    Richard M. Siegel;Francis Ka-Ming Chan;Hyung J. Chun;Michael J. Lenardo

  • Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.

    F K Chan;J Zhang;L Cheng;D N Shapiro

  • CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

    Monika C. Brunner;Cynthia A. Chambers;Francis Ka Ming Chan;Jeff Hanke

  • Functional complementation between FADD and RIP1 in embryos and lymphocytes

    Haibing Zhang;Xiaohui Zhou;Xiaohui Zhou;Thomas McQuade;Jinghe Li

  • RIP3: a molecular switch for necrosis and inflammation.

    Kenta Moriwaki;Francis Ka-Ming Chan

  • Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

    Francis Ka-Ming Chan;Nivea Farias Luz;Kenta Moriwaki

  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

    Barbara J. Cainan;Sharman Szychowski;Francis Ka-Ming Chan;Dragana Cado

  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis.

    Laurence Eng‐Chee Cheng;Francis Ka‐Ming Chan;Dragana Cado;Astar Winoto

Frequent Co-Authors

Bruce A. Menge
Bruce A. Menge Oregon State University
Michael J. Lenardo
Michael J. Lenardo National Institute of Allergy and Infectious Diseases
Peter J. Gough
Peter J. Gough Inzen Therapeutics
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Richard M. Siegel
Richard M. Siegel National Institutes of Health
John Bertin
John Bertin GlaxoSmithKline (United Kingdom)
Gyorgy Szabadkai
Gyorgy Szabadkai University College London
Astar Winoto
Astar Winoto University of California, Berkeley
Jane Lubchenco
Jane Lubchenco Oregon State University
John A. Barth
John A. Barth Oregon State University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Francis Ka-Ming Chan

Trending Scientists

Recently Published Articles