Peter J. Gough

Overview

Best Publications

• Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

  William J. Kaiser;Haripriya Sridharan;Chunzi Huang;Pratyusha Mandal

  1008
  Citations

• Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

  Pontus Orning;Pontus Orning;Dan Weng;Dan Weng;Kristian Starheim;Kristian Starheim;Dmitry Ratner

  975
  Citations

• MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

  Yves Dondelinger;Wim Declercq;Sylvie Montessuit;Ria Roelandt

  822
  Citations

• Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).

  Kyle J. Garton;Peter J. Gough;Carl P. Blobel;Gillian Murphy

  794
  Citations

• RIP3 induces apoptosis independent of pronecrotic kinase activity.

  Pratyusha Mandal;Scott B. Berger;Sirika Pillay;Kenta Moriwaki

  642
  Citations

• Design of amidobenzimidazole STING receptor agonists with systemic activity

  J.M. Ramanjulu;G.S. Pesiridis;J. Yang;N. Concha

  637
  Citations

• Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice

  Peter J. Gough;Ivan G. Gomez;Paul T. Wille;Elaine W. Raines

  555
  Citations

• Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

  Marietta Zille;Saravanan S. Karuppagounder;Yingxin Chen;Peter J. Gough

  508
  Citations

• Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

  Philip A. Harris;Scott B. Berger;Jae U. Jeong;Rakesh Nagilla

  463
  Citations

• NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

  Yves Dondelinger;Sandrine Jouan-Lanhouet;Tatyana Divert;Emilie Theatre

  419
  Citations

• Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

  Scott B. Berger;Viera Kasparcova;Sandy Hoffman;Barb Swift

  406
  Citations

• RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

  Shoko Nogusa;Roshan J. Thapa;Christopher P. Dillon;Swantje Liedmann

  382
  Citations

• Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

  Dan Weng;Robyn Lynn Marty-Roix;Sandhya Ganesan;Megan K. Proulx

  330
  Citations

• Stimulated Shedding of Vascular Cell Adhesion Molecule 1 (VCAM-1) Is Mediated by Tumor Necrosis Factor-α-converting Enzyme (ADAM 17)

  Kyle J. Garton;Peter J. Gough;Julie Philalay;Paul T. Wille

  329
  Citations

• RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

  Nozomi Takahashi;Lars Vereecke;Mathieu J. M. Bertrand;Linde Duprez

  320
  Citations

• RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

  William J. Kaiser;Lisa P. Daley-Bauer;Roshan J. Thapa;Pratyusha Mandal

  309
  Citations

• Macrophage Class A Scavenger Receptor-Mediated Phagocytosis of Escherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro

  Leanne Peiser;Peter J. Gough;Tatsuhiko Kodama;Siamon Gordon

  306
  Citations

• A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16

  Peter J. Gough;Kyle J. Garton;Paul T. Wille;Marcin Rychlewski

  305
  Citations

• Emerging roles for ectodomain shedding in the regulation of inflammatory responses

  Kyle J. Garton;Peter J. Gough;Elaine W. Raines

  286
  Citations

• RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.

  Kay Hänggi;Lazaros Vasilikos;Aida Freire Valls;Rosario Yerbes

  69
  Citations