2026 James M. Murphy: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	74	1239	1103	31	30	199	17363

Overview

James M. Murphy is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research predominantly spans the field of Biochemistry, Genetics and Molecular Biology, contributing extensively to molecular biology, immunology, cell biology, oncology, and genetics.

Their research focuses notably on cell death mechanisms and regulation, interferon and immune responses, PARP inhibition in cancer therapy, phagocytosis and immune regulation, Hippo pathway signaling and YAP/TAZ, inflammasome and immune disorders, and nuclear structure and function.

Recent significant publications include:

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis (2020, Nature Communications)
Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease (2021, American Journal of Respiratory and Critical Care Medicine)
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis (2021, Cell Death and Differentiation)
Sublethal necroptosis signaling promotes inflammation and liver cancer (2023, Immunity)
The regulation of necroptosis by post-translational modifications (2021, Cell Death and Differentiation)

These works reflect a sustained focus on necroptosis and related cell death pathways and their roles in inflammation, cancer, and neurodegeneration.

Frequent collaborators include:

André L. Samson
Samuel N. Young
Christopher R. Horne
Joanne M. Hildebrand
Sarah E. Garnish

James M. Murphy publishes regularly in the following venues:

bioRxiv (Cold Spring Harbor Laboratory) with 17 publications
Nature Communications with 14 publications
Cell Death and Differentiation with 9 publications
Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature with 9 publications
Biochemical Journal with 7 publications

Best Publications

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

1187
Citations
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

634
Citations
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

553
Citations
Rheumatoid arthritis-interstitial lung disease-associated mortality.

Amy L. Olson;Jeffrey J. Swigris;David B. Sprunger;Aryeh Fischer

550
Citations
Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells.

R.M. Dwyer;S.M. Potter-Beirne;K.A. Harrington;A.J. Lowery

521
Citations
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Stephanie A. Conos;Stephanie A. Conos;Kaiwen W Chen;Dominic De Nardo;Dominic De Nardo;Hideki Hara

474
Citations
The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas P. D. Liau;Nicholas P. D. Liau;Artem Laktyushin;Artem Laktyushin;Isabelle S. Lucet;Isabelle S. Lucet;James M. Murphy;James M. Murphy

360
Citations
The molecular regulation of Janus kinase (JAK) activation.

Jeffrey J. Babon;Jeffrey J. Babon;Isabelle S. Lucet;Isabelle S. Lucet;James M. Murphy;James M. Murphy;Nicos A. Nicola;Nicos A. Nicola

332
Citations
Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Jeffrey J Babon;Nadia J Kershaw;Nadia J Kershaw;James M Murphy;James M Murphy;Leila N Varghese;Leila N Varghese

311
Citations
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure.

Tammo Müller;Christin Dewitz;Jessica Schmitz;Anna Sophia Schröder

306
Citations
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Nadia J Kershaw;James M Murphy;James M Murphy;Nicholas P D Liau;Nicholas P D Liau;Leila N Varghese;Leila N Varghese

300
Citations
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

Isabel Jaco;Alessandro Annibaldi;Najoua Lalaoui;Najoua Lalaoui;Rebecca Wilson

296
Citations
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

James M. Murphy;James M. Murphy;Qingwei Zhang;Samuel N. Young;Michael L. Reese

280
Citations
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Andre L Samson;Andre L Samson;Ying Zhang;Ying Zhang;Niall D Geoghegan;Niall D Geoghegan;Xavier J Gavin

266
Citations
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James A Rickard;Holly Anderton;Nima Etemadi;Ueli Nachbur

263
Citations
Regulated necrosis in kidney ischemia-reperfusion injury.

Aspasia Pefanis;Francesco L. Ierino;James M. Murphy;Peter J. Cowan;Peter J. Cowan

249
Citations
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

Jakub Gruszczyk;Usheer Kanjee;Li Jin Chan;Li Jin Chan;Sébastien Menant

231
Citations
Understanding the Roles of FAK in Cancer Inhibitors, Genetic Models, and New Insights

Hyunho Yoon;Joshua P. Dehart;James M. Murphy;Ssang-Taek Steve Lim

215
Citations
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- And RIPK3-dependent manner

W. Wei-Lynn Wong;W. Wei-Lynn Wong;W. Wei-Lynn Wong;James E. Vince;James E. Vince;Najoua Lalaoui;Najoua Lalaoui;Kate E. Lawlor;Kate E. Lawlor

182
Citations
Author response: TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James A Rickard;James A Rickard;Holly Anderton;Holly Anderton;Nima Etemadi;Nima Etemadi;Ueli Nachbur;Ueli Nachbur

1
Citations

Frequent Co-Authors

John Silke Walter and Eliza Hall Institute of Medical Research

Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research

Andrew I. Webb Walter and Eliza Hall Institute of Medical Research

Jeffrey J. Babon Walter and Eliza Hall Institute of Medical Research

Warren S. Alexander Walter and Eliza Hall Institute of Medical Research

Nicos A. Nicola Walter and Eliza Hall Institute of Medical Research

James E. Vince Walter and Eliza Hall Institute of Medical Research

Guillaume Lessene Walter and Eliza Hall Institute of Medical Research

David L. Vaux Walter and Eliza Hall Institute of Medical Research

Ian G. Young Australian National University

External Links

Personal website of James M. Murphy

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