2015 - Gottschalk Medal, Australian Academy of Science
Peter E. Czabotar mainly investigates Cell biology, Programmed cell death, Apoptosis, Protein structure and Bcl-2-associated X protein. Peter E. Czabotar has included themes like Membrane protein, Cell membrane and Ligand in his Cell biology study. His Programmed cell death research focuses on Necroptosis and Myeloid Cell Leukemia Sequence 1 Protein.
The study incorporates disciplines such as Pyroptosis, Autophagy, Entosis, Protein kinase A and Immunogenic cell death in addition to Necroptosis. His Apoptosis research incorporates themes from Cancer, Cancer research and Neuroscience. His Protein structure research incorporates elements of Peptide sequence and Protein–protein interaction.
Peter E. Czabotar mainly focuses on Cell biology, Programmed cell death, Protein structure, Apoptosis and Necroptosis. His work on Effector, Mitochondrion and Signal transduction as part of general Cell biology research is frequently linked to Bcl-2-associated X protein, thereby connecting diverse disciplines of science. Bcl-2 family and Intrinsic apoptosis are among the areas of Programmed cell death where Peter E. Czabotar concentrates his study.
Peter E. Czabotar interconnects Biophysics, Binding site, Peptide sequence and Plasma protein binding in the investigation of issues within Protein structure. His studies in Apoptosis integrate themes in fields like Cancer, Cancer research and Cell. His study looks at the relationship between Necroptosis and topics such as Phosphorylation, which overlap with Protein domain.
Peter E. Czabotar spends much of his time researching Cell biology, Necroptosis, Programmed cell death, Effector and Phosphorylation. His Cell biology research is multidisciplinary, incorporating perspectives in Ubiquitin, Ubiquitin ligase, Cross-presentation and Antigen. His study in Necroptosis is interdisciplinary in nature, drawing from both Phenotype, Missense mutation, Mutation and Cancer research.
His Programmed cell death study deals with the bigger picture of Apoptosis. His Effector research focuses on Protein kinase A and how it relates to Photoaffinity labeling, Serine, Signal transducing adaptor protein and Transport protein. His Phosphorylation study combines topics in areas such as Protein structure, Kinase and Cell membrane.
Effector, Cell biology, Necroptosis, Programmed cell death and Phosphorylation are his primary areas of study. The Effector study combines topics in areas such as Transport protein, Protein structure, Signal transducing adaptor protein and Protein kinase A. His Protein structure study incorporates themes from Papain, Ubiquitin, ISG15 and Protease.
His Necroptosis research integrates issues from Phenotype, Missense mutation and Compound heterozygosity. His Programmed cell death study is focused on Apoptosis in general. His biological study spans a wide range of topics, including Xenopus, Cell membrane, HEK 293 cells, Signal transduction and Regulator.
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Peter E Czabotar;Guillaume Lessene;Andreas Strasser;Jerry M Adams.
Nature Reviews Molecular Cell Biology (2014)
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft.
Science (2007)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Mark F. van Delft;Andrew H. Wei;Kylie D. Mason;Kylie D. Mason;Cassandra J. Vandenberg.
Cancer Cell (2006)
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet.
Immunity (2013)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams.
Nature (2018)
BCL-2 family antagonists for cancer therapy
Guillaume Lessene;Peter E. Czabotar;Peter M. Colman.
Nature Reviews Drug Discovery (2008)
Molecular biology of Bax and Bak activation and action
Dana Westphal;Grant Dewson;Peter E. Czabotar;Ruth M. Kluck.
Biochimica et Biophysica Acta (2011)
Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma.
Cell (2013)
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young.
Proceedings of the National Academy of Sciences of the United States of America (2014)
Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Peter E. Czabotar;Erinna F. Lee;Mark F. van Delft;Catherine L. Day.
Proceedings of the National Academy of Sciences of the United States of America (2007)
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