D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 48 Citations 16,597 127 World Ranking 13883 National Ranking 386

Research.com Recognitions

Awards & Achievements

2015 - Gottschalk Medal, Australian Academy of Science

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Amino acid

Peter E. Czabotar mainly investigates Cell biology, Programmed cell death, Apoptosis, Protein structure and Bcl-2-associated X protein. Peter E. Czabotar has included themes like Membrane protein, Cell membrane and Ligand in his Cell biology study. His Programmed cell death research focuses on Necroptosis and Myeloid Cell Leukemia Sequence 1 Protein.

The study incorporates disciplines such as Pyroptosis, Autophagy, Entosis, Protein kinase A and Immunogenic cell death in addition to Necroptosis. His Apoptosis research incorporates themes from Cancer, Cancer research and Neuroscience. His Protein structure research incorporates elements of Peptide sequence and Protein–protein interaction.

His most cited work include:

  • Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy (1632 citations)
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. (1421 citations)
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. (1421 citations)

What are the main themes of his work throughout his whole career to date?

Peter E. Czabotar mainly focuses on Cell biology, Programmed cell death, Protein structure, Apoptosis and Necroptosis. His work on Effector, Mitochondrion and Signal transduction as part of general Cell biology research is frequently linked to Bcl-2-associated X protein, thereby connecting diverse disciplines of science. Bcl-2 family and Intrinsic apoptosis are among the areas of Programmed cell death where Peter E. Czabotar concentrates his study.

Peter E. Czabotar interconnects Biophysics, Binding site, Peptide sequence and Plasma protein binding in the investigation of issues within Protein structure. His studies in Apoptosis integrate themes in fields like Cancer, Cancer research and Cell. His study looks at the relationship between Necroptosis and topics such as Phosphorylation, which overlap with Protein domain.

He most often published in these fields:

  • Cell biology (76.06%)
  • Programmed cell death (50.53%)
  • Protein structure (36.17%)

What were the highlights of his more recent work (between 2019-2021)?

  • Cell biology (76.06%)
  • Necroptosis (35.64%)
  • Programmed cell death (50.53%)

In recent papers he was focusing on the following fields of study:

Peter E. Czabotar spends much of his time researching Cell biology, Necroptosis, Programmed cell death, Effector and Phosphorylation. His Cell biology research is multidisciplinary, incorporating perspectives in Ubiquitin, Ubiquitin ligase, Cross-presentation and Antigen. His study in Necroptosis is interdisciplinary in nature, drawing from both Phenotype, Missense mutation, Mutation and Cancer research.

His Programmed cell death study deals with the bigger picture of Apoptosis. His Effector research focuses on Protein kinase A and how it relates to Photoaffinity labeling, Serine, Signal transducing adaptor protein and Transport protein. His Phosphorylation study combines topics in areas such as Protein structure, Kinase and Cell membrane.

Between 2019 and 2021, his most popular works were:

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. (54 citations)
  • Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax (28 citations)
  • Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax (28 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

Effector, Cell biology, Necroptosis, Programmed cell death and Phosphorylation are his primary areas of study. The Effector study combines topics in areas such as Transport protein, Protein structure, Signal transducing adaptor protein and Protein kinase A. His Protein structure study incorporates themes from Papain, Ubiquitin, ISG15 and Protease.

His Necroptosis research integrates issues from Phenotype, Missense mutation and Compound heterozygosity. His Programmed cell death study is focused on Apoptosis in general. His biological study spans a wide range of topics, including Xenopus, Cell membrane, HEK 293 cells, Signal transduction and Regulator.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E Czabotar;Guillaume Lessene;Andreas Strasser;Jerry M Adams.
Nature Reviews Molecular Cell Biology (2014)

2796 Citations

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft.
Science (2007)

1403 Citations

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

Mark F. van Delft;Andrew H. Wei;Kylie D. Mason;Kylie D. Mason;Cassandra J. Vandenberg.
Cancer Cell (2006)

1389 Citations

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet.
Immunity (2013)

939 Citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams.
Nature (2018)

784 Citations

BCL-2 family antagonists for cancer therapy

Guillaume Lessene;Peter E. Czabotar;Peter M. Colman.
Nature Reviews Drug Discovery (2008)

682 Citations

Molecular biology of Bax and Bak activation and action

Dana Westphal;Grant Dewson;Peter E. Czabotar;Ruth M. Kluck.
Biochimica et Biophysica Acta (2011)

603 Citations

Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma.
Cell (2013)

545 Citations

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young.
Proceedings of the National Academy of Sciences of the United States of America (2014)

445 Citations

Structural insights into the degradation of Mcl-1 induced by BH3 domains.

Peter E. Czabotar;Erinna F. Lee;Mark F. van Delft;Catherine L. Day.
Proceedings of the National Academy of Sciences of the United States of America (2007)

441 Citations

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