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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
28610
World Ranking
9969
National Ranking
265

Research.com Recognitions

  • 2015 - Gottschalk Medal, Australian Academy of Science

Overview

Peter E. Czabotar is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research primarily focuses on the biochemical and molecular biological mechanisms underlying cell death processes, with significant contributions to the understanding of apoptosis and mitochondrial function.

Their publication record includes a number of recent papers, notable among these are:

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2, 2020, The EMBO Journal
  • Mechanisms of BCL-2 family proteins in mitochondrial apoptosis, 2023, Nature Reviews Molecular Cell Biology
  • The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs, 2021, Nature Reviews Cancer
  • Apoptotic cell death in disease-Current understanding of the NCCD 2023, 2023, Cell Death and Differentiation
  • Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax, 2020, Blood

Peter E. Czabotar frequently collaborates with several researchers, including:

  • Richard W. Birkinshaw
  • Ana J. García-Sáez
  • James M. Murphy
  • Séamus J. Martin
  • Dublin Chair

Their research is regularly published in journals such as:

  • FEBS Journal
  • Nature Communications
  • Cell Death and Differentiation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Structure

Peter E. Czabotar's main fields of study encompass biochemistry, genetics, and molecular biology, along with medicine. Their work has a strong emphasis on several subfields:

  • Molecular Biology
  • Immunology
  • Oncology
  • Genetics
  • Cell Biology

The primary topics covered in their research include:

  • Cell death mechanisms and regulation
  • RNA interference and gene delivery
  • Interferon and immune responses
  • PARP inhibition in cancer therapy
  • Hippo pathway signaling and YAP/TAZ
  • Peptidase inhibition and analysis
  • Mitochondrial function and pathology

In recognition of their scientific contributions, Peter E. Czabotar received the Gottschalk Medal from the Australian Academy of Science in 2015.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

    Peter E Czabotar;Guillaume Lessene;Andreas Strasser;Jerry M Adams

  • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

    Mark F. van Delft;Andrew H. Wei;Kylie D. Mason;Kylie D. Mason;Cassandra J. Vandenberg

  • Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

    Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft

  • The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

    James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

  • BCL-2 family antagonists for cancer therapy

    Guillaume Lessene;Peter E. Czabotar;Peter M. Colman

  • Molecular biology of Bax and Bak activation and action

    Dana Westphal;Grant Dewson;Peter E. Czabotar;Ruth M. Kluck

  • Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

    Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma

  • Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

  • Structural insights into the degradation of Mcl-1 induced by BH3 domains.

    Peter E. Czabotar;Erinna F. Lee;Mark F. van Delft;Catherine L. Day

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

    Theresa Klemm;Gregor Ebert;Dale J Calleja;Cody C Allison

  • Structure-guided design of a selective BCL-XL inhibitor

    Guillaume Lessene;Guillaume Lessene;Peter Edward Czabotar;Peter Edward Czabotar;Brad Sleebs;Brad Sleebs;Kerry Zobel

  • The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

    Jian Guo Zhang;Jian Guo Zhang;Peter E. Czabotar;Peter E. Czabotar;Antonia N. Policheni;Antonia N. Policheni;Irina Caminschi;Irina Caminschi;Irina Caminschi

  • Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia.

    Piers Blombery;Piers Blombery;Mary Ann Anderson;Mary Ann Anderson;Mary Ann Anderson;Jia-nan Gong;Jia-nan Gong;Rachel Thijssen;Rachel Thijssen

  • Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

    E F Lee;E F Lee;P E Czabotar;B J Smith;K Deshayes

  • Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

    Zhi-Fu Tao;Lisa Hasvold;Le Wang;Xilu Wang

  • Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.

    M Kvansakul;H Yang;W D Fairlie;P E Czabotar

  • Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

    Grant Dewson;Tobias Kratina;Peter Czabotar;Catherine L. Day

  • The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs.

    Sarah T Diepstraten;Mary Ann Anderson;Peter E Czabotar;Peter E Czabotar;Guillaume Lessene;Guillaume Lessene

  • The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

    Richard W Birkinshaw;Peter E Czabotar;Peter E Czabotar

Frequent Co-Authors

Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
James M. Murphy
James M. Murphy Walter and Eliza Hall Institute of Medical Research
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Grant Dewson
Grant Dewson Walter and Eliza Hall Institute of Medical Research
Jonathan B. Baell
Jonathan B. Baell Monash University
John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Andrew I. Webb
Andrew I. Webb Walter and Eliza Hall Institute of Medical Research

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