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Biology and Biochemistry

D-Index
55
Citations
23911
World Ranking
14741
National Ranking
404

Overview

Grant Dewson is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research spans multiple interconnected fields within biochemistry, genetics, and molecular biology, with significant contributions to medicine.

The main fields of study for Dewson include biochemistry, genetics, and molecular biology, supported by a body of 51 publications. Medicine represents another major area, encompassing 29 publications. Subfields include molecular biology with 37 publications, immunology (10), epidemiology (8), genetics (7), and cell biology (6).

Dewson's work covers several primary topics of research:

  • Cell death mechanisms and regulation
  • Autophagy in disease and therapy
  • Ubiquitin and proteasome pathways
  • RNA interference and gene delivery
  • Interferon and immune responses
  • NF-κB signaling pathways
  • Parkinson's disease mechanisms and treatments

Their publication record includes papers in several frequent venues:

  • bioRxiv (Cold Spring Harbor Laboratory), 9 publications
  • The EMBO Journal, 3 publications
  • Cell Death and Differentiation, 3 publications
  • Nature, 2 publications
  • Science Advances, 2 publications

Recent papers by Dewson and collaborators include:

  • "Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2" (2020, The EMBO Journal)
  • "Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities" (2021, Cell Death and Differentiation)
  • "Mitochondria and cell death" (2024, Nature Cell Biology)
  • "Mesenchymal stromal cell apoptosis is required for their therapeutic function" (2021, Nature Communications)
  • "Deubiquitinases in cancer" (2023, Nature Reviews Cancer)

Dewson has collaborated frequently with several researchers, including:

  • Peter E. Czabotar
  • David Komander
  • David C.S. Huang
  • Mark F. van Delft
  • Richard W. Birkinshaw

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins

    Simon N. Willis;Lin Chen;Grant Dewson;Andrew Wei

  • BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

    Kate McArthur;Kate McArthur;Kate McArthur;Lachlan W. Whitehead;Lachlan W. Whitehead;John M. Heddleston;Lucy Li

  • Molecular biology of Bax and Bak activation and action

    Dana Westphal;Grant Dewson;Peter E. Czabotar;Ruth M. Kluck

  • RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

    James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

  • Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

    Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

    Theresa Klemm;Gregor Ebert;Dale J Calleja;Cody C Allison

  • Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis.

    D Westphal;R M Kluck;G Dewson

  • Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

    Grant Dewson;Ruth M. Kluck

  • To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

    Grant Dewson;Tobias Kratina;Huiyan W. Sim;Hamsa Puthalakath

  • Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

    Nicholas D Huntington;Hamsa Puthalakath;Priscilla Gunn;Edwina Naik;Edwina Naik

  • Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities.

    Marlene F. Schmidt;Zhong Yan Gan;Zhong Yan Gan;David Komander;David Komander;Grant Dewson;Grant Dewson

  • Parkin and mitophagy in cancer

    J. P. Bernardini;M Lazarou;Grant Dewson;Grant Dewson

  • Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

    Grant Dewson;Tobias Kratina;Peter Czabotar;Catherine L. Day

  • Mitochondrial Release of Pro-apoptotic Proteins ELECTROSTATIC INTERACTIONS CAN HOLD CYTOCHROME c BUT NOT Smac/DIABLO TO MITOCHONDRIAL MEMBRANES

    Rachel T Uren;Grant Dewson;Christine Bonzon;Trevor James Lithgow

  • Bax dimerizes via a symmetric BH3:groove interface during apoptosis

    G Dewson;S Ma;P Frederick;P Frederick;C Hockings

  • Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

    Delphine Merino;Delphine Merino;James R. Whittle;James R. Whittle;James R. Whittle;François Vaillant;François Vaillant;Antonin Serrano;Antonin Serrano

  • Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow.

    Gerrit Woltmann;Claire A. McNulty;Grant Dewson;Fiona A. Symon

  • Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

    Rachel T. Uren;Grant Dewson;Lin Chen;Stephanie C. Coyne

  • Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

    Jason M. Brouwer;Jason M. Brouwer;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Adeline Y. Robin;Adeline Y. Robin

Frequent Co-Authors

Ruth M. Kluck
Ruth M. Kluck Walter and Eliza Hall Institute of Medical Research
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
Gordon K. Smyth
Gordon K. Smyth Walter and Eliza Hall Institute of Medical Research
Jerry M. Adams
Jerry M. Adams Walter and Eliza Hall Institute of Medical Research
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Erinna F. Lee
Erinna F. Lee La Trobe University

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