Ruth M. Kluck

Overview

Best Publications

• The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

  Ruth M. Kluck;Ella Bossy-Wetzel;Douglas R. Green;Donald D. Newmeyer

  6080
  Citations

• Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.

  Elizabeth A. Slee;Mary T. Harte;Ruth M. Kluck;Beni B. Wolf

  2524
  Citations

• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

  Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft

  1447
  Citations

• Molecular biology of Bax and Bak activation and action

  Dana Westphal;Grant Dewson;Peter E. Czabotar;Ruth M. Kluck

  662
  Citations

• Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

  Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma

  617
  Citations

• Cytochrome c activation of CPP32‐like proteolysis plays a critical role in a Xenopus cell‐free apoptosis system

  Ruth M. Kluck;Seamus J. Martin;Brian M. Hoffman;Jian S. Zhou

  573
  Citations

• Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis.

  D Westphal;R M Kluck;G Dewson

  436
  Citations

• Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

  Grant Dewson;Ruth M. Kluck

  411
  Citations

• The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

  Ruth M Kluck;Mauro Dogli Esposti;Guy Perkins;Christian Renken

  407
  Citations

• To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

  Grant Dewson;Tobias Kratina;Huiyan W. Sim;Hamsa Puthalakath

  387
  Citations

• Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release.

  Oliver von Ahsen;Christian Renken;Guy Perkins;Ruth M. Kluck

  331
  Citations

• Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

  Grant Dewson;Tobias Kratina;Peter Czabotar;Catherine L. Day

  252
  Citations

• Mitochondrial Release of Pro-apoptotic Proteins ELECTROSTATIC INTERACTIONS CAN HOLD CYTOCHROME c BUT NOT Smac/DIABLO TO MITOCHONDRIAL MEMBRANES

  Rachel T Uren;Grant Dewson;Christine Bonzon;Trevor James Lithgow

  212
  Citations

• A Distinct Pathway of Cell-Mediated Apoptosis Initiated by Granulysin

  Allan A. Kaspar;Satoshi Okada;Jayant Kumar;Francis R. Poulain

  208
  Citations

• Bax dimerizes via a symmetric BH3:groove interface during apoptosis

  G Dewson;S Ma;P Frederick;P Frederick;C Hockings

  206
  Citations

• Determinants of Cytochrome c Pro-apoptotic Activity: THE ROLE OF LYSINE 72 TRIMETHYLATION *

  Ruth M. Kluck;Lisa M. Ellerby;H.Michael Ellerby;Shahrouz Naiem

  175
  Citations

• Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

  Rachel T. Uren;Grant Dewson;Lin Chen;Stephanie C. Coyne

  170
  Citations

• Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

  Jason M. Brouwer;Jason M. Brouwer;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Adeline Y. Robin;Adeline Y. Robin

  159
  Citations

• VDAC2 enables BAX to mediate apoptosis and limit tumor development.

  Hui San Chin;Hui San Chin;Mark X. Li;Mark X. Li;Iris K. L. Tan;Robert L. Ninnis;Robert L. Ninnis

  152
  Citations

• Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

  Dana Westphal;Grant Dewson;Marie Menard;Paul Frederick

  147
  Citations