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Klaus Schulze-Osthoff

Klaus Schulze-Osthoff

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
121
Citations
49115
World Ranking
612
National Ranking
42

Medicine

D-Index
121
Citations
49088
World Ranking
3632
National Ranking
196

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Klaus Schulze-Osthoff is affiliated with the University of Tübingen in Germany and has an extensive record of research publications primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their scientific work spans multiple subfields including Molecular Biology, Cancer Research, Oncology, Immunology, and Epidemiology.

Their research covers a number of focused topics, such as:

  • Liver Disease Diagnosis and Treatment
  • Cancer Genomics and Diagnostics
  • Fibroblast Growth Factor Research
  • NF-κB Signaling Pathways
  • Protein Degradation and Inhibitors
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Immune Response and Inflammation

Schulze-Osthoff has published frequently in several scientific journals. The most common venues include:

  • Zeitschrift für Gastroenterologie
  • Cell Death and Disease
  • Journal of Investigative Dermatology
  • Liver International
  • Cancer Research

Some of the recent papers associated with their research are:

  • "Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers," 2021, Cancer Discovery
  • "Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL," 2021, Blood
  • "TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice," 2020, Cell Death and Disease
  • "Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers," 2022, Annals of Oncology
  • "The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis," 2020, Journal of Clinical Investigation

In collaborative research, Schulze-Osthoff frequently works with several researchers, including:

  • Michael Bitzer
  • Stephan Hailfinger
  • Katharina John
  • Heike Bantel
  • Heiner Wedemeyer

Best Publications

  • Many cuts to ruin: a comprehensive update of caspase substrates

    U Fischer;R U Jänicke;K Schulze-Osthoff

  • Apoptosis signaling by death receptors

    Klaus Schulze-Osthoff;Davide Ferrari;Marek Los;Sebastian Wesselborg

  • Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

    Kirsten Lauber;Erwin Bohn;Stefan Martin Kröber;Yi Jin Xiao

  • Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

    K Schulzeosthoff;Ac Bakker;Bart Vanhaesebroeck;Rudi Beyaert

  • Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.

    Heike Schenk;Matthias Klein;Wilhelm Erdbrugger;Wulf Droge

  • T-helper-1-cell cytokines drive cancer into senescence

    Heidi Braumüller;Thomas Wieder;Ellen Brenner;Sonja Aßmann

  • Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

    Marek Los;Marek Los;Marc Van de Craen;Louis C. Penning;Heike Schenk

  • Small Stress Proteins as Novel Regulators of Apoptosis HEAT SHOCK PROTEIN 27 BLOCKs FAS/APO-1- AND STAUROSPORINE-INDUCED CELL DEATH

    Patrick Mehlen;Klaus Schulze-Osthoff;André-Patrick Arrigo

  • PARP is important for genomic stability but dispensable in apoptosis

    Zhao-Qi Wang;Laura Stingl;Ciaran Morrison;Michael Jantsch

  • Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

    K Schulzeosthoff;Rudi Beyaert;Veronique Vandevoorde;Guy Haegeman

  • Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

    Susanne Feil;Birgit Fehrenbacher;Robert Lukowski;Frank Essmann

  • Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling

    Marek Los;Malgorzata Mozoluk;Davide Ferrari;Anna Stepczynska

  • Functions of glutathione and glutathione disulfide in immunology and immunopathology.

    Wulf Dröge;Klaus Schulze-Osthoff;Sabine Mihm;Dagmar Galter

  • Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

    Paolo Pinton;Davide Ferrari;Paulo Magalhães;Klaus Schulze-Osthoff

  • The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction: Lessons from Knockout Mice

    Marek Los;Sebastian Wesselborg;Klaus Schulze-Osthoff

  • Cell nucleus and DNA fragmentation are not required for apoptosis

    Klaus Schulze-Osthoff;Henning Walczak;Wulf Dröge;Peter H. Krammer

  • Regulation of apoptosis by alternative pre-mRNA splicing.

    Christian Schwerk;Klaus Schulze-Osthoff

  • Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis

    C P Berg;I H Engels;A Rothbart;K Lauber

  • Cancer stem cell markers in common cancers – therapeutic implications

    Thomas Klonisch;Emilia Wiechec;Sabine Hombach-Klonisch;Sudharsana R. Ande

  • SESQUITERPENE LACTONES SPECIFICALLY INHIBIT ACTIVATION OF NF-λB BY PREVENTING THE DEGRADATION OF IλB-α AND IλB-$g(b)

    Michael Heinrich;M. Lienhard Schmitz

Frequent Co-Authors

Frank Essmann
Frank Essmann University of Tübingen
Marek Los
Marek Los Silesian University of Technology
Sebastian Wesselborg
Sebastian Wesselborg University of Tübingen
Peter T. Daniel
Peter T. Daniel Max Delbrück Center for Molecular Medicine
Michael P. Manns
Michael P. Manns Hannover Medical School
Claus Belka
Claus Belka Ludwig-Maximilians-Universität München
Kirsten Lauber
Kirsten Lauber Ludwig-Maximilians-Universität München
Walter Fiers
Walter Fiers Ghent University
Bernd Dörken
Bernd Dörken Charité - University Medicine Berlin
Davide Ferrari
Davide Ferrari University of Ferrara

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