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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
30434
World Ranking
16904
National Ranking
6963

Overview

Donald D. Newmeyer is affiliated with the La Jolla Institute For Allergy & Immunology in the United States. Their research spans several fields within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and epidemiology as subfields of study.

The scientist's main research topics include:

  • Autophagy in Disease and Therapy
  • Cell death mechanisms and regulation
  • Mitochondrial Function and Pathology
  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Cancer therapeutics and mechanisms
  • Histone Deacetylase Inhibitors Research

Newmeyer's work has been published notably in:

  • Journal of Biological Chemistry (2 publications)
  • Life (1 publication)
  • bioRxiv (Cold Spring Harbor Laboratory) (1 publication)

Selected recent papers include:

  • "Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization," 2020, Journal of Biological Chemistry
  • "Targeting Ca2+ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells," 2022, Life
  • "Disruption of mitochondrial quality control genes promotes caspase-resistant cell survival following apoptotic stimuli," 2022, Journal of Biological Chemistry
  • "Disruption of Mitochondrial Quality Control Genes Promotes Caspase-Resistant Cell Survival Following Apoptotic Stimuli," 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include:

  • Tomomi Kuwana
  • Julian Suess
  • Vivian Moraes
  • Yulia Kushnareva
  • Bjoern Peters

Best Publications

  • The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

    Ruth M. Kluck;Ella Bossy-Wetzel;Douglas R. Green;Donald D. Newmeyer

  • Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.

    Elizabeth A. Slee;Mary T. Harte;Ruth M. Kluck;Beni B. Wolf

  • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.

    Jerry E. Chipuk;Tomomi Kuwana;Lisa Bouchier-Hayes;Nathalie M. Droin

  • Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

    Tomomi Kuwana;Mason R. Mackey;Guy Perkins;Mark H. Ellisman

  • Mitochondria - Releasing Power for Life and Unleashing the Machineries of Death

    Donald D Newmeyer;Shelagh Ferguson-Miller

  • Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

    Ella Bossy‐Wetzel;Donald D. Newmeyer;Douglas R. Green

  • BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

    Tomomi Kuwana;Lisa Bouchier-Hayes;Jerry E. Chipuk;Christine Bonzon

  • Bcl-2-family proteins and the role of mitochondria in apoptosis.

    Tomomi Kuwana;Donald D Newmeyer

  • Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

    Donal D. Newmeyer;Donal D. Newmeyer;David M. Farschon;John C. Reed

  • PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.

    Jerry E. Chipuk;Lisa Bouchier-Hayes;Lisa Bouchier-Hayes;Tomomi Kuwana;Tomomi Kuwana;Donald D. Newmeyer;Donald D. Newmeyer

  • Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation.

    Donald D. Newmeyer;Douglass J. Forbes

  • Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

    D R Finlay;D D Newmeyer;T M Price;D J Forbes

  • GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

    Anna Colell;Jean-Ehrland Ricci;Stephen Tait;Sandra Milasta

  • Cytochrome c activation of CPP32‐like proteolysis plays a critical role in a Xenopus cell‐free apoptosis system

    Ruth M. Kluck;Seamus J. Martin;Brian M. Hoffman;Jian S. Zhou

  • Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

    Nigel J. Waterhouse;Joshua C. Goldstein;Oliver von Ahsen;Martin Schuler

  • Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c

    Tomomi Kuwana;Jesse J. Smith;Marta Muzio;Vishva Dixit

  • The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

    Ruth M Kluck;Mauro Dogli Esposti;Guy Perkins;Christian Renken

  • Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

    S. J. Martin;D. D. Newmeyer;S. Mathias;D. M. Farschon

  • Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release.

    Oliver von Ahsen;Christian Renken;Guy Perkins;Ruth M. Kluck

  • Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

    Ryuji Yamaguchi;Lydia Lartigue;Guy A Perkins;Ray T Scott

Frequent Co-Authors

Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Ruth M. Kluck
Ruth M. Kluck Walter and Eliza Hall Institute of Medical Research
Ella Bossy-Wetzel
Ella Bossy-Wetzel University of Central Florida
Guy A. Perkins
Guy A. Perkins University of California, San Diego
Jerry E. Chipuk
Jerry E. Chipuk Icahn School of Medicine at Mount Sinai
Nigel J. Waterhouse
Nigel J. Waterhouse QIMR Berghofer Medical Research Institute
Douglass J. Forbes
Douglass J. Forbes University of California, San Diego
Seamus J. Martin
Seamus J. Martin Trinity College Dublin
Mark H. Ellisman
Mark H. Ellisman University of California, San Diego
Bjoern Peters
Bjoern Peters La Jolla Institute For Allergy & Immunology

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