2026 Nigel J. Waterhouse: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	48	18250	16755	532	512	96	11579

Overview

Nigel J. Waterhouse is affiliated with the QIMR Berghofer Medical Research Institute in Australia. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a strong focus on Oncology and Immunology as subfields. Their scholarly work addresses various aspects of cancer treatment, immunotherapy, and biomedical applications.

The main topics covered in Waterhouse's research include:

Cancer Immunotherapy and Biomarkers
Immunotherapy and Immune Responses
Cancer, Stress, Anesthesia, and Immune Response
Colorectal Cancer Treatments and Studies
Cancer Cells and Metastasis
Computational Drug Discovery Methods
3D Printing in Biomedical Research

The scientist's publication record includes the following recent papers:

"Immune contexture analysis in immuno-oncology: applications and challenges of multiplex fluorescent immunohistochemistry," 2020, Clinical & Translational Immunology
"Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors," 2023, Journal for ImmunoTherapy of Cancer
"Strategies to reduce the use of non-human primates in development of oncology ADCs with cytotoxic payloads," 2025, Regulatory Toxicology and Pharmacology
"341 A phase Ib expansion cohort of pixatimod plus nivolumab in previously treated, microsatellite stable metastatic colorectal cancer (MSS mCRC)," 2021, Regular and Young Investigator Award Abstracts
"Two-Year Inhalation Studies in Mice and Rats With HFO-1234ze(E), a Near Zero Global Warming Potential Propellant for Use in Pressurized Metered Dose Inhalers," 2025, International Journal of Toxicology

Frequent coauthors collaborating with Waterhouse include:

Charlotte Lemech
Keith Dredge
Darryn Bampton
Edward Hammond
Amanda C. Stanley

The regular publication venues for Waterhouse's work include:

Journal for ImmunoTherapy of Cancer
Clinical & Translational Immunology
Regulatory Toxicology and Pharmacology
Regular and Young Investigator Award Abstracts
International Journal of Toxicology

Best Publications

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant.

Joshua C. Goldstein;Joshua C. Goldstein;Nigel J. Waterhouse;Phillipe Juin;Gerard I. Evan

1324
Citations
Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

Deborah M. Finucane;Ella Bossy-Wetzel;Nigel J. Waterhouse;Thomas G. Cotter

955
Citations
GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

Anna Colell;Jean-Ehrland Ricci;Stephen Tait;Sandra Milasta

591
Citations
Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

Nigel J. Waterhouse;Joshua C. Goldstein;Oliver von Ahsen;Martin Schuler

519
Citations
Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity.

Purnima Bhat;Graham Leggatt;Nigel J Waterhouse;Ian H Frazer

518
Citations
Quantitation of Apoptosis and Necrosis by Annexin V Binding, Propidium Iodide Uptake, and Flow Cytometry

Lisa C. Crowley;Brooke J. Marfell;Adrian P. Scott;Nigel J. Waterhouse;Nigel J. Waterhouse;Nigel J. Waterhouse

467
Citations
Novel Mechanisms of Apoptosis Induced by Histone Deacetylase Inhibitors

Melissa J Peart;Kellie M Tainton;Astrid A Ruefli;Anthony E Dear

320
Citations
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

Mandy J. Ludford-Menting;Jane Oliaro;Faruk Sacirbegovic;Eric T.-Y. Cheah

314
Citations
Measuring Cell Death by Propidium Iodide Uptake and Flow Cytometry.

Lisa C. Crowley;Adrian P. Scott;Brooke J. Marfell;Jeanne A. Boughaba

314
Citations
Analyzing Cell Death by Nuclear Staining with Hoechst 33342.

Lisa C. Crowley;Brooke J. Marfell;Nigel J. Waterhouse

290
Citations
Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway.

Michael J. Pinkoski;Nigel J. Waterhouse;Jeffrey A. Heibein;Beni B. Wolf

248
Citations
Calpain activation is upstream of caspases in radiation- induced apoptosis

Nigel J Waterhouse;Debra M Finucane;Douglas R Green;John S Elce

242
Citations
Detecting Cleaved Caspase-3 in Apoptotic Cells by Flow Cytometry.

Lisa C. Crowley;Nigel J. Waterhouse;Nigel J. Waterhouse;Nigel J. Waterhouse

225
Citations
Tumor cell-selective cytotoxicity by targeting cell cycle checkpoints

Robyn Warrener;Heather Beamish;Andrew Burgess;Nigel J. Waterhouse

185
Citations
A new quantitative assay for cytochrome c release in apoptotic cells.

N J Waterhouse;J A Trapani

184
Citations
Granzyme M Mediates a Novel Form of Perforin-dependent Cell Death

Janice M. Kelly;Nigel J. Waterhouse;Erika Cretney;Kylie A. Browne

175
Citations
And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis.

Nigel J. Waterhouse;Jean-Ehrland Ricci;Douglas R. Green

175
Citations
The 'harmless' release of cytochrome c.

O Von Ahsen;N J Waterhouse;T Kuwana;D D Newmeyer

174
Citations
Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.

Deborah M. Finucane;Nigel J. Waterhouse;Gustavo P. Amarante-Mendes;Thomas G. Cotter

171
Citations
Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1β-converting enzyme-like proteases in apoptosis

Nigel Waterhouse;Sharad Kumar;Qizhong Song;Phil Strike

167
Citations