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Biology and Biochemistry

D-Index
58
Citations
9604
World Ranking
13417
National Ranking
374

Overview

Brian Gabrielli is a researcher affiliated with the University of Queensland in Australia. Their work primarily focuses on biochemistry, genetics, molecular biology, and medicine, with a significant emphasis on oncology and molecular biology. They have contributed extensively to several subfields including oncology, immunology, cell biology, and immunology and allergy.

Their recent papers cover a diverse array of topics related to cancer biology and treatment mechanisms. Notable publications include:

  • Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture (2020, bioRxiv - Cold Spring Harbor Laboratory)
  • Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours (2021, Oncogenesis)
  • Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression (2021, Cancers)
  • Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells (2024, British Journal of Cancer)
  • Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition (2024, Cell Death and Disease)

Brian Gabrielli often collaborates with a number of co-authors who are significant contributors to their research projects. Frequent collaborators include Martina Proctor, Shivam Vora, Jazmina L. Gonzalez Cruz, Nikolas K. Haass, and John D. Hooper.

Their research is published in venues that include bioRxiv (Cold Spring Harbor Laboratory), Cancers, Cell Death and Disease, Oncogenesis, and the British Journal of Cancer. They have multiple publications in bioRxiv and Cancers, reflecting ongoing engagement with both preprint and peer-reviewed platforms.

Key topics covered by their research include:

  • Cancer-related Molecular Pathways
  • Microtubule and mitosis dynamics
  • Cancer Immunotherapy and Biomarkers
  • Cell Adhesion Molecules Research
  • Immune cells in cancer
  • Melanoma and MAPK Pathways
  • Cellular Mechanics and Interactions

Overall, the body of work presents a focus on the molecular and cellular mechanisms underlying cancer development, progression, and therapeutic intervention, with a particular interest in the immune responses and chemotherapy enhancement strategies.

Best Publications

  • ATM associates with and phosphorylates p53: mapping the region of interaction

    Kum Kum Khanna.;Katherine E. Keating;Sergei Kozlov;Shaun Scott

  • Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis

    Megan Fabbro;Bin-Bing Zhou;Mikiko Takahashi;Boris Sarcevic

  • The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

    Nicole Cloonan;Mellissa K Brown;Anita L Steptoe;Shivangi Wani

  • Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells

    Ling Qiu;Andrew Burgess;David P. Fairlie;Helen Leonard

  • Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

    B. G. Gabrielli;C. P. C. De Souza;I. D. Tonks;J. M. Clark

  • Histone-Deacetylase Inhibitors for the Treatment of Cancer

    Ralph K. Lindemann;Brian G. Gabrielli;Ricky W. Johnstone

  • Evidence for label-retaining tumour-initiating cells in human glioblastoma

    Loic P. Deleyrolle;Angus Harding;Kathleen Cato;Florian A. Siebzehnrubl

  • APC mutation and tumour budding in colorectal cancer

    J R Jass;M Barker;L Fraser;M D Walsh

  • Up-regulation of p21(WAF1/CIP1) by histone deacetylase inhibitors reduces their cytotoxicity.

    Andrew J. Burgess;Sandra Pavey;Robyn Warrener;Lisa-Jane K. Hunter

  • Tumor cell-selective cytotoxicity by targeting cell cycle checkpoints

    Robyn Warrener;Heather Beamish;Andrew Burgess;Nigel J. Waterhouse

  • Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events.

    C. P. C. De Souza;K. A. O. Ellem;B. G. Gabrielli

  • CDKN2A/p16 is inactivated in most melanoma cell lines.

    Marina Castellano;Pamela M. Pollock;Marilyn K. Walters;Louise E. Sparrow

  • A stress-induced early innate response causes multidrug tolerance in melanoma

    D Ravindran Menon;D Ravindran Menon;S Das;C Krepler;A Vultur

  • Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.

    L De Boer;V Oakes;H Beamish;N Giles

  • Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

    Andrew Burgess;Astrid Ruefli;Heather Beamish;Robyn Warrener

  • Cell cycle regulation of the p34cdc2 inhibitory kinases.

    Sue Atherton-Fessler;Feng Liu;Brian Gabrielli;Margaret S. Lee

  • RNA Interference against Human Papillomavirus Oncogenes in Cervical Cancer Cells Results in Increased Sensitivity to Cisplatin

    Lisa N. Putral;Megan J. Bywater;Wenyi Gu;Nicholas A. Saunders

  • Regulation of CDC25B phosphatases subcellular localization

    Noélie Davezac;Véronique Baldin;Brian Gabrielli;Alistair Forrest

  • Hyperphosphorylation of the N-terminal Domain of Cdc25 Regulates Activity toward Cyclin B1/Cdc2 But Not Cyclin A/Cdk2

    Brian G. Gabrielli;Joanne M. Clark;Andrew K. McCormack;Kay A.O. Ellem

  • MicroRNA-182-5p targets a network of genes involved in DNA repair

    Keerthana Krishnan;Anita L. Steptoe;Hilary C. Martin;Shivangi Wani

Frequent Co-Authors

Nikolas K. Haass
Nikolas K. Haass University of Queensland
Thomas J. Gonda
Thomas J. Gonda University of South Australia
Wolfgang Weninger
Wolfgang Weninger Medical University of Vienna
Richard A. Sturm
Richard A. Sturm University of Queensland
Nicholas K. Hayward
Nicholas K. Hayward QIMR Berghofer Medical Research Institute
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Peter G. Parsons
Peter G. Parsons QIMR Berghofer Medical Research Institute
Alistair R. R. Forrest
Alistair R. R. Forrest Harry Perkins Institute of Medical Research
H. Peter Soyer
H. Peter Soyer University of Queensland
James L. Maller
James L. Maller University of Colorado Denver

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