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Michael B. Yaffe

Michael B. Yaffe

D-Index & Metrics

Biology and Biochemistry

D-Index
118
Citations
58287
World Ranking
696
National Ranking
441

Overview

Michael B. Yaffe is a researcher primarily affiliated with MIT in the United States. Their work spans several fields, notably Medicine and Biochemistry, Genetics, and Molecular Biology, with a substantial focus on Molecular Biology and Immunology as leading subfields. Other areas of research include Oncology, Pulmonary and Respiratory Medicine, and Infectious Diseases.

The scientist's research addresses diverse topics in biomedical science. Key areas include COVID-19 Clinical Research Studies, DNA Repair Mechanisms, Immune Cells in Cancer, Long-Term Effects of COVID-19, Respiratory Support and Mechanisms, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, and Microtubule and Mitosis Dynamics.

Michael B. Yaffe's publication record features numerous articles published in well-regarded venues. Frequent publication venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The Journal of Trauma: Injury, Infection, and Critical Care
  • The Journal of Immunology

Among recent papers, several are noted for their scientific contributions and citation counts. Representative publications include:

  • "An atlas of substrate specificities for the human serine/threonine kinome" (2023), published in Nature
  • "Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series" (2020), published in Journal of Thrombosis and Haemostasis
  • "ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A comment" (2020), published in Journal of Thrombosis and Haemostasis
  • "BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage" (2020), published in Nature Communications
  • "The intrinsic substrate specificity of the human tyrosine kinome" (2024), published in Nature

Frequent co-authors collaborating with Michael B. Yaffe include:

  • Christopher D. Barrett
  • Ernest E. Moore
  • Hunter B. Moore
  • Yi Wen Kong
  • Brian A. Joughin

Best Publications

  • The structural basis for 14-3-3:phosphopeptide binding specificity.

    Michael B Yaffe;Katrin Rittinger;Stefano Volinia;Paul R Caron

  • Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs

    John C. Obenauer;Lewis C. Cantley;Michael B. Yaffe

  • MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

    Manuel Stucki;Julie A. Clapperton;Duaa Mohammad;Michael B. Yaffe

  • The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

    P. P. Hsu;S. A. Kang;J. Rameseder;Y. Zhang

  • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.

    Jeong Ho Hong;Eun Sook Hwang;Michael T. McManus;Adam Amsterdam

  • RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly.

    Michael S.Y. Huen;Robert Grant;Isaac Manke;Kay Minn

  • Systematic Discovery of In Vivo Phosphorylation Networks

    Rune Linding;Rune Linding;Lars Juhl Jensen;Gerard J. Ostheimer;Marcel A.T.M. van Vugt;Marcel A.T.M. van Vugt

  • Sequence-specific and phosphorylation dependent proline isomerization: A potential mitotic regulatory mechanism

    Michael B. Yaffe;Mike Schutkowski;Minhui Shen;Xiao Zhen Zhou

  • How do 14-3-3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis

    Michael B Yaffe

  • Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates

    Andrew E. H. Elia;Lewis C. Cantley;Michael B. Yaffe

  • The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

    Andrew E.H. Elia;Peter Rellos;Lesley F. Haire;Jerry W. Chao

  • 14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

    Sandeep Robert Datta;Alex Katsov;Linda Hu;Andrew Petros

  • The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

    Fumihiko Kanai;Hui Liu;Seth J. Field;Seth J. Field;Hares Akbary

  • TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

    Fumihiko Kanai;Paola A. Marignani;Dilara Sarbassova;Ryohei Yagi;Ryohei Yagi

  • Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

    Libor Macůrek;Arne Lindqvist;Dan Lim;Michael A. Lampson

  • TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

    Xaralabos Varelas;Rui Sakuma;Payman Samavarchi-Tehrani;Raheem Peerani

  • Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A

    José Aramburu;Michael B. Yaffe;Cristina López-Rodrı́guez;Lewis C. Cantley

  • Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

    Michael J. Lee;Albert S. Ye;Albert S. Ye;Alexandra K. Gardino;Anne Margriet Heijink

  • p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

    H. Christian Reinhardt;Aaron S. Aslanian;Jacqueline A. Lees;Michael B. Yaffe

  • BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

    Isaac A. Manke;Drew M. Lowery;Anhco Nguyen;Michael B. Yaffe

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
Stephen J. Smerdon
Stephen J. Smerdon University of Birmingham
Ernest E. Moore
Ernest E. Moore University of Colorado Denver
Terrence R. Burke
Terrence R. Burke National Institutes of Health
Andrew E. H. Elia
Andrew E. H. Elia Harvard University
Vuk Stambolic
Vuk Stambolic University of Toronto
Peter K. Sorger
Peter K. Sorger Harvard University

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