Terrence R. Burke spends much of his time researching Stereochemistry, Integrase, Biochemistry, Peptide and SH2 domain. His work deals with themes such as Chemical synthesis, Small molecule and Active site, which intersect with Stereochemistry. His biological study spans a wide range of topics, including Molecular biology and Enzyme inhibitor, Enzyme.
The study incorporates disciplines such as Lead compound, IC50 and Structure–activity relationship in addition to Enzyme inhibitor. His study in Peptide is interdisciplinary in nature, drawing from both Phosphonate, Phosphatase and Phenylalanine. Terrence R. Burke interconnects Tumor necrosis factor alpha, Okadaic acid, Transcription factor and Ceramide in the investigation of issues within Protein subunit.
Terrence R. Burke mainly investigates Stereochemistry, Biochemistry, Peptide, Integrase and SH2 domain. In his research on the topic of Stereochemistry, Membrane is strongly related with Binding site. His work in Peptide addresses issues such as Phenylalanine, which are connected to fields such as Enantioselective synthesis.
Terrence R. Burke usually deals with Integrase and limits it to topics linked to Virology and Mutant. His SH2 domain study incorporates themes from Cyclic peptide, GRB2 and Ligand. His Protein tyrosine phosphatase research includes elements of Yersinia pestis and Small molecule.
His primary areas of study are Integrase, Stereochemistry, Biochemistry, Peptide and PLK1. His Integrase research integrates issues from Strand transfer, Mutant and Virology. His studies in Stereochemistry integrate themes in fields like Residue, Tyrosyl-DNA phosphodiesterase and Histidine.
The Biochemistry study combines topics in areas such as Conjugated system and Drug. His biological study spans a wide range of topics, including Amino acid, Phosphothreonine, Protein tyrosine phosphatase and Protein–protein interaction. His PLK1 research is multidisciplinary, incorporating perspectives in Computational biology, Kinase, Bioinformatics and Polo-like kinase.
His scientific interests lie mostly in Integrase, Biochemistry, Virology, Raltegravir and Computational biology. His work on Integrases as part of general Integrase research is frequently linked to Dolutegravir, thereby connecting diverse disciplines of science. In his works, Terrence R. Burke performs multidisciplinary study on Biochemistry and Conjugate.
His Virology study combines topics from a wide range of disciplines, such as Structure–activity relationship and Mutant. Raltegravir is integrated with Potency, Raltegravir Potassium and Stereochemistry in his research. His Stereochemistry research is multidisciplinary, relying on both Phosphoserine, Pivaloyloxymethyl, Polo kinase, Peptide and Histidine.
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Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B
K. Natarajan;Sanjaya Singh;Terrence R. Burke;Dezider Grunberger.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
Masaya Baba;Seung-Beom Hong;Nirmala Sharma;Michelle B. Warren.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Coumarin-based inhibitors of HIV integrase.
He Zhao;Nouri Neamati;Huixiao Hong;Abhijit Mazumder.
Journal of Medicinal Chemistry (1997)
Potent Inhibition of Insulin Receptor Dephosphorylation by a Hexamer Peptide Containing the Phosphotyrosyl Mimetic F2Pmp
T.R. Burke;H.K. Kole;P.P. Roller.
Biochemical and Biophysical Research Communications (1994)
Retroviral DNA integration: reaction pathway and critical intermediates.
Min Li;Michiyo Mizuuchi;Terrence R Burke;Robert Craigie.
The EMBO Journal (2006)
Hydroxylated aromatic inhibitors of HIV-1 integrase.
T. R. Burke;M. R. Fesen;Abhijit Mazumder;Jian Wang.
Journal of Medicinal Chemistry (1995)
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Godwin C. G. Pais;Xuechun Zhang;Christophe Marchand;Nouri Neamati.
Journal of Medicinal Chemistry (2002)
Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery.
Terrence R. Burke;Zhong Yin Zhang.
Preparation of fluoro- and hydroxy-4-(phosphonomethyl)-D,L-phenylalanine suitably protected for solid-phase synthesis of peptides containing hydrolytically stable analogs of O-phosphotyrosine
Terrence R. Burke;Mark S. Smyth;Motoyoshi Nomizu;Akira Otaka.
Journal of Organic Chemistry (1993)
Nonhydrolyzable Phosphotyrosyl Mimetics for the Preparation Of Phosphatase-Resistant SH2 Domain Inhibitors
Terrence R. Jr. Burke;Mark S. Smyth;Akira Otaka;Motoyoshi Nomizu.
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