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Biology and Biochemistry

D-Index
80
Citations
20775
World Ranking
4135
National Ranking
2028

Overview

Nouri Neamati is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with specific emphasis on molecular biology, oncology, cell biology, infectious diseases, and epidemiology.

The scientist's recent publications highlight a focus on molecular mechanisms related to disease processes, cancer, and cellular stress responses. Notable papers include:

  • Role of the ERO1-PDI interaction in oxidative protein folding and disease (2020, Pharmacology & Therapeutics)
  • Why All the Fuss about Oxidative Phosphorylation (OXPHOS)? (2020, Journal of Medicinal Chemistry)
  • The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer (2021, Cancer Research)
  • Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy (2023, Nature Communications)
  • Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91 (2021, Journal of Medicinal Chemistry)

The main topics of their work include:

  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • SARS-CoV-2 and COVID-19 Research
  • Cytokine Signaling Pathways and Interactions
  • COVID-19 Clinical Research Studies

Neamati's frequent co-authors reflect collaborations across several prominent researchers, including Mats Ljungman, Armita Kyani, Yibin Xu, Ding Xue, and Duxin Sun.

The scientist has published extensively in respected academic venues, with a significant number of papers appearing in:

  • Journal of Medicinal Chemistry
  • European Journal of Medicinal Chemistry
  • ACS Pharmacology & Translational Science
  • Cancer Research
  • Neoplasia

Their work addresses complex biomedical challenges such as oxidative protein folding, apoptosis in cancer cells, and innovative chemoimmunotherapy approaches involving nanomedicine. This research portfolio encompasses experimental and mechanistic studies, often focusing on molecular targets relevant to cancer and infectious diseases.

Best Publications

  • Role of the CXCL8-CXCR1/2 axis in cancer and inflammatory diseases

    Helen Ha;Bikash Debnath;Nouri Neamati

  • Coumarin-based inhibitors of HIV integrase.

    He Zhao;Nouri Neamati;Huixiao Hong;Abhijit Mazumder

  • Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery.

    Xiaoyuan Chen;Carmen Plasencia;Yingping Hou;Nouri Neamati

  • Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

    Nouri Neamati;Huixiao Hong;Abhijit Mazumder;Shaomeng Wang

  • Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

    Divya Pathania;Melissa Millard;Nouri Neamati

  • Small Molecule Inhibitors of CXCR4

    Bikash Debnath;Shili Xu;Fedora Grande;Antonio Garofalo

  • Protein disulfide isomerase: a promising target for cancer therapy.

    Shili Xu;Saranya Sankar;Nouri Neamati

  • Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

    Godwin C. G. Pais;Xuechun Zhang;Christophe Marchand;Nouri Neamati

  • Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4

    Qian Zhao;Liying Ma;Shibo Jiang;Hong Lu

  • In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide.

    Yanbin Ji;Subhabrata Majumder;Melissa Millard;Radhika Borra

  • Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

    Shili Xu;Alexey N. Butkevich;Roppei Yamada;Yu Zhou

  • Chicoric acid analogues as HIV-1 integrase inhibitors.

    Zhaiwei Lin;Nouri Neamati;He Zhao;Yoshimitsu Kiryu

  • Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein

    Bikash Debnath;Shili Xu;Nouri Neamati

  • HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.

    Marc C. Nicklaus;Nouri Neamati;Huixiao Hong;Abhijit Mazumder

  • Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors

    Erik Serrao;Srinivas Odde;Kavya Ramkumar;Nouri Neamati

  • Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

    Abhijit Mazumder;Shaomeng Wang;Nouri Neamati;Marc Nicklaus

  • Copper-transporting P-type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP.

    Kentaro Nakayama;Atsuko Kanzaki;Kenji Ogawa;Kohji Miyazaki

  • Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.

    Jinxia Deng;Tino Sanchez;Laith Q. Al-Mawsawi;Raveendra Dayam

  • Structural Determinants for HIV-1 Integrase Inhibition by β-Diketo Acids

    Christophe Marchand;Xuechun Zhang;Godwin C.G. Pais;Kiriana Cowansage

  • Design and Synthesis of Novel Indole β-Diketo Acid Derivatives as HIV-1 Integrase Inhibitors

    Mario Sechi;Massimiliano Derudas;Roberto Dallocchio;Alessandro Dessì

Frequent Co-Authors

Zeger Debyser
Zeger Debyser KU Leuven
Frauke Christ
Frauke Christ KU Leuven
Terrence R. Burke
Terrence R. Burke National Institutes of Health
Fabrizio Carta
Fabrizio Carta University of Florence
Christoph H. Borchers
Christoph H. Borchers McGill University
Xiaoyuan Chen
Xiaoyuan Chen National University of Singapore
Nicos A. Petasis
Nicos A. Petasis University of Southern California
Valter D. Longo
Valter D. Longo University of Southern California
Gang Niu
Gang Niu Xi'an Jiaotong University

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