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Homme W. Hellinga

Homme W. Hellinga

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
10342
World Ranking
14519
National Ranking
6101

Research.com Recognitions

  • 2004 - National Institutes of Health Director's Pioneer Award

Overview

Homme W. Hellinga is affiliated with Duke University in the United States. Their scholarly work primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on specialized subfields including Molecular Biology, Genetics, Materials Chemistry, Infectious Diseases, and Epidemiology.

The scientist's research topics cover a diverse set of areas such as RNA and protein synthesis mechanisms, protein structure and dynamics, bacterial genetics and biotechnology, enzyme structure and function, antifungal resistance and susceptibility, fungal infections and studies, and peptidase inhibition and analysis.

Frequent co-authors collaborating with Homme W. Hellinga include:

  • Malin Allert
  • You Wang
  • L.S. Beese
  • Yuqian Shi
  • S. Kumar

Research contributions have been published in various scientific venues, including:

  • Journal of Molecular Biology
  • Biochemistry
  • Journal of Medicinal Chemistry
  • Nucleic Acids Research
  • Communications Chemistry

Selected recent publications by Homme W. Hellinga are:

  • "Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium," 2020, Journal of Molecular Biology
  • "Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase," 2022, Journal of Medicinal Chemistry
  • "Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics," 2023, Nucleic Acids Research
  • "Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation," 2022, Biochemistry
  • "Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching," 2023, Communications Chemistry

Homme W. Hellinga received the National Institutes of Health Director's Pioneer Award in 2004, acknowledging contributions to their field.

Best Publications

  • Computational design of receptor and sensor proteins with novel functions

    Loren L. Looger;Mary A. Dwyer;James J. Smith;Homme W. Hellinga

  • Periplasmic binding proteins: a versatile superfamily for protein engineering

    Mary A Dwyer;Homme W Hellinga

  • Computational Design of a Biologically Active Enzyme

    Mary A. Dwyer;Loren L. Looger;Homme W. Hellinga

  • Construction of a fluorescent biosensor family

    Robert M. De Lorimier;J. Jeff Smith;Mary A. Dwyer;Loren L. Looger

  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.

    Homme W. Hellinga;Frederic M. Richards

  • Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.

    Weina Wang;Homme W. Hellinga;Lorena S. Beese

  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics.

    Loren L. Looger;Homme W. Hellinga

  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors

    J. S. Marvin;E. E. Corcoran;N. A. Hattangadi;J. V. Zhang

  • Engineering Biosensors by Introducing Fluorescent Allosteric Signal Transducers: Construction of a Novel Glucose Sensor

    Jonathan S. Marvin;Homme W. Hellinga

  • Conversion of a maltose receptor into a zinc biosensor by computational design

    Jonathan S. Marvin;Homme W. Hellinga

  • Optimal sequence selection in proteins of known structure by simulated evolution.

    H W Hellinga;F M Richards

  • Protein engineering and the development of generic biosensors

    Homme W Hellinga;Jonathan S Marvin

  • Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase.

    Homme W. Hellinga;Philip R. Evans

  • Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins

    David E. Benson;David W. Conrad;Robert M. de;Lorimier

  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch

    Haiqing Liu;Jacob J. Schmidt;George D. Bachand;Shahir S. Rizk

  • Manipulation of ligand binding affinity by exploitation of conformational coupling.

    Jonathan S. Marvin;Homme W. Hellinga

  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin.

    H W Hellinga;J P Caradonna;F M Richards

  • Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

    Jillian Orans;Elizabeth A. McSweeney;Ravi R. Iyer;Michael A. Hast

  • Structural analysis, identification, and design of calcium-binding sites in proteins.

    Wei Yang;Hsiau-Wei Lee;Homme Hellinga;Jenny J. Yang

  • Rational design of nascent metalloenzymes.

    David E. Benson;Michael S. Wisz;Homme W. Hellinga

Frequent Co-Authors

Loren L. Looger
Loren L. Looger Howard Hughes Medical Institute
Lorena S. Beese
Lorena S. Beese Duke University
Frederic M. Richards
Frederic M. Richards Yale University
John E. Ladbury
John E. Ladbury University of Leeds
Paul Modrich
Paul Modrich Duke University
Julian M. Sturtevant
Julian M. Sturtevant Yale University
S. Scott Saavedra
S. Scott Saavedra University of Arizona
J. Andrew Alspaugh
J. Andrew Alspaugh Duke University
Leslie M. Loew
Leslie M. Loew University of Connecticut
Donald Hilvert
Donald Hilvert ETH Zurich

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