World's Best Scientists 2026 revealed!
Homme W. Hellinga

Homme W. Hellinga

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
10342
World Ranking
14519
National Ranking
6101

Homme W. Hellinga publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Homme W. Hellinga sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 128 publications — 16th percentile

16% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Homme W. Hellinga D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Homme W. Hellinga sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 56 D-Index — 28th percentile

28% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2004 - National Institutes of Health Director's Pioneer Award

Overview

Homme W. Hellinga is affiliated with Duke University in the United States. Their scholarly work primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on specialized subfields including Molecular Biology, Genetics, Materials Chemistry, Infectious Diseases, and Epidemiology.

The scientist's research topics cover a diverse set of areas such as RNA and protein synthesis mechanisms, protein structure and dynamics, bacterial genetics and biotechnology, enzyme structure and function, antifungal resistance and susceptibility, fungal infections and studies, and peptidase inhibition and analysis.

Frequent co-authors collaborating with Homme W. Hellinga include:

  • Malin Allert
  • You Wang
  • L.S. Beese
  • Yuqian Shi
  • S. Kumar

Research contributions have been published in various scientific venues, including:

  • Journal of Molecular Biology
  • Biochemistry
  • Journal of Medicinal Chemistry
  • Nucleic Acids Research
  • Communications Chemistry

Selected recent publications by Homme W. Hellinga are:

  • "Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium," 2020, Journal of Molecular Biology
  • "Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase," 2022, Journal of Medicinal Chemistry
  • "Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics," 2023, Nucleic Acids Research
  • "Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation," 2022, Biochemistry
  • "Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching," 2023, Communications Chemistry

Homme W. Hellinga received the National Institutes of Health Director's Pioneer Award in 2004, acknowledging contributions to their field.

Best Publications

  • Computational design of receptor and sensor proteins with novel functions

    Loren L. Looger;Mary A. Dwyer;James J. Smith;Homme W. Hellinga

  • Periplasmic binding proteins: a versatile superfamily for protein engineering

    Mary A Dwyer;Homme W Hellinga

  • Computational Design of a Biologically Active Enzyme

    Mary A. Dwyer;Loren L. Looger;Homme W. Hellinga

  • Construction of a fluorescent biosensor family

    Robert M. De Lorimier;J. Jeff Smith;Mary A. Dwyer;Loren L. Looger

  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.

    Homme W. Hellinga;Frederic M. Richards

  • Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.

    Weina Wang;Homme W. Hellinga;Lorena S. Beese

  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics.

    Loren L. Looger;Homme W. Hellinga

  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors

    J. S. Marvin;E. E. Corcoran;N. A. Hattangadi;J. V. Zhang

  • Engineering Biosensors by Introducing Fluorescent Allosteric Signal Transducers: Construction of a Novel Glucose Sensor

    Jonathan S. Marvin;Homme W. Hellinga

  • Conversion of a maltose receptor into a zinc biosensor by computational design

    Jonathan S. Marvin;Homme W. Hellinga

  • Optimal sequence selection in proteins of known structure by simulated evolution.

    H W Hellinga;F M Richards

  • Protein engineering and the development of generic biosensors

    Homme W Hellinga;Jonathan S Marvin

  • Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase.

    Homme W. Hellinga;Philip R. Evans

  • Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins

    David E. Benson;David W. Conrad;Robert M. de;Lorimier

  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch

    Haiqing Liu;Jacob J. Schmidt;George D. Bachand;Shahir S. Rizk

  • Manipulation of ligand binding affinity by exploitation of conformational coupling.

    Jonathan S. Marvin;Homme W. Hellinga

  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin.

    H W Hellinga;J P Caradonna;F M Richards

  • Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

    Jillian Orans;Elizabeth A. McSweeney;Ravi R. Iyer;Michael A. Hast

  • Structural analysis, identification, and design of calcium-binding sites in proteins.

    Wei Yang;Hsiau-Wei Lee;Homme Hellinga;Jenny J. Yang

  • Rational design of nascent metalloenzymes.

    David E. Benson;Michael S. Wisz;Homme W. Hellinga

Frequent Co-Authors

Loren L. Looger
Loren L. Looger Howard Hughes Medical Institute
Lorena S. Beese
Lorena S. Beese Duke University
Frederic M. Richards
Frederic M. Richards Yale University
John E. Ladbury
John E. Ladbury University of Leeds
Paul Modrich
Paul Modrich Duke University
Julian M. Sturtevant
Julian M. Sturtevant Yale University
S. Scott Saavedra
S. Scott Saavedra University of Arizona
J. Andrew Alspaugh
J. Andrew Alspaugh Duke University
Leslie M. Loew
Leslie M. Loew University of Connecticut
Donald Hilvert
Donald Hilvert ETH Zurich

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