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Chemistry

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Molecular Biology

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Overview

John E. Ladbury is affiliated with the University of Leeds in the United Kingdom and has a research focus primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their work spans several specialized subfields including Molecular Biology, Cell Biology, Cancer Research, Biophysics, and Immunology.

The scientist's research topics cover a range of areas, with particular emphasis on:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Fibroblast Growth Factor Research
  • Protein Kinase Regulation and GTPase Signaling
  • Protein Structure and Dynamics
  • Cell Image Analysis Techniques
  • Epigenetics and DNA Methylation

Ladbury has contributed to numerous research publications, with recent papers including:

  • "Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state" (2022) published in Molecular Cell
  • "Phase separation enhances probability of receptor signalling and drug targeting" (2023) published in Trends in Biochemical Sciences
  • "DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans" (2020) published in Nature Communications
  • "Grb2 binding induces phosphorylation-independent activation of Shp2" (2021) published in Communications Biology
  • "Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction" (2021) published in Scientific Reports

The scientist frequently publishes alongside co-authors such as Chi-Chuan Lin, Kin Man Suen, Arndt Rohwedder, Sabine Knipp, and Łukasz Wieteska.

Among the venues where John E. Ladbury's work is commonly published are:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology
  • Scientific Reports
  • Life Science Alliance

Best Publications

  • A landscape of driver mutations in melanoma

    Eran Hodis;Ian R. Watson;Ian R. Watson;Gregory V. Kryukov;Gregory V. Kryukov;Gregory V. Kryukov;Stefan T. Arold

  • Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

    Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien;John Edward Simon Durham Ladbury

  • Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

    S M Roe;C Prodromou;R O'Brien;J E Ladbury

  • ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

    Barry Panaretou;Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien

  • Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.

    T. Spivak-Kroizman;M.A. Lemmon;I. Dikic;J.E. Ladbury

  • Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

    Susanne A.I. Seidel;Patricia M. Dijkman;Wendy A. Lea;Geert van den Bogaart

  • Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.

    John Edward Simon Durham Ladbury

  • The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N-terminal domains

    Chrisostomos Prodromou;Barry Panaretou;Barry Panaretou;Shahzad Chohan;Giuliano Siligardi

  • Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

    Chrisostomos Prodromou;Giuliano Siligardi;Ronan O'Brien;Derek N. Woolfson

  • Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions.

    John Edward Simon Durham Ladbury;Babur Z. Chowdhry

  • Two EGF molecules contribute additively to stabilization of the EGFR dimer

    Mark A. Lemmon;Zimei Bu;John Edward Simon Durham Ladbury;Min Zhou;Min Zhou

  • Adding calorimetric data to decision making in lead discovery: a hot tip

    John E. Ladbury;Gerhard Klebe;Ernesto Freire

  • Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

    Chia Hsin Chan;John Kenneth Morrow;John Kenneth Morrow;Chien Feng Li;Yuan Gao;Yuan Gao

  • Structure and Interactions of the Human Programmed Cell Death 1 Receptor

    Xiaoxiao Cheng;Vaclav Veverka;Anand Radhakrishnan;Lorna C. Waters

  • The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.

    Tjelvar S.G. Olsson;Mark A. Williams;William R. Pitt;John E. Ladbury

  • TCR binding to peptide-MHC stabilizes a flexible recognition interface.

    Benjamin E. Willcox;George F. Gao;Jessica R. Wyer;John Edward Simon Durham Ladbury

  • Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies.

    Ihtshamul Haq;Ihtshamul Haq;John E Ladbury;Babur Z Chowdhry;Terence C Jenkins

  • Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

    John E. Ladbury;Mark A. Lemmon;Min Zhou;Jeremy Green

  • A Thermodynamic Study of the trp Repressor—Operator Interaction

    John E. Ladbury;Jeffrey G. Wright;Julian M. Sturtevant;Paul B. Sigler

  • Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.

    Elena Baraldi;Kristina Djinovic Carugo;Marko Hyvönen;Paola Lo Surdo

Frequent Co-Authors

Stefan T. Arold
Stefan T. Arold King Abdullah University of Science and Technology
Eric A. Miska
Eric A. Miska University of Cambridge
Paul C. Driscoll
Paul C. Driscoll University College London
Mien Chie Hung
Mien Chie Hung China Medical University
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Joseph Schlessinger
Joseph Schlessinger Yale University
Mark A. Lemmon
Mark A. Lemmon Yale University
Julian M. Sturtevant
Julian M. Sturtevant Yale University
Chrisostomos Prodromou
Chrisostomos Prodromou University of Sussex
Michael D. Waterfield
Michael D. Waterfield Ludwig Cancer Research

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