World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
98
Citations
45251
World Ranking
1630
National Ranking
910

Research.com Recognitions

  • 2016 - Fellow of the Royal Society, United Kingdom

Overview

Mark A. Lemmon is affiliated with Yale University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on Molecular Biology, Oncology, Immunology, Pulmonary and Respiratory Medicine, and Neurology.

The scientist's recent publications include the following papers:

  • Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases (2020, Molecular Cell)
  • Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics (2020, Science Signaling)
  • Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias (2022, Nature)
  • Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers (2021, Cancer Research)
  • Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations (2020, Cancer Research)

Frequent co-authors include:

  • Yuko Tsutsui (11 co-publications)
  • Kumar Dilip Ashtekar (9 co-publications)
  • Steven E. Stayrook (8 co-publications)
  • Joshua B. Sheetz (7 co-publications)
  • Courtney M. Smith (7 co-publications)

Mark A. Lemmon has published extensively in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Nature Communications (3 publications)
  • Nature (2 publications)
  • Cancer Research (2 publications)
  • Biochemical Journal (2 publications)

The main research topics addressed include:

  • Lung Cancer Treatments and Mutations
  • Cancer therapeutics and mechanisms
  • HER2/EGFR in Cancer Research
  • Neuroblastoma Research and Treatments
  • PI3K/AKT/mTOR signaling in cancer
  • Monoclonal and Polyclonal Antibodies Research
  • Galectins and Cancer Biology

Mark A. Lemmon was awarded the title of Fellow of the Royal Society, United Kingdom, in 2016.

Best Publications

  • Cell signaling by receptor-tyrosine kinases

    Mark A. Lemmon;Joseph Schlessinger

  • Membrane recognition by phospholipid-binding domains.

    Mark A. Lemmon

  • An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

    Antony W. Burgess;Hyun Soo Cho;Hyun Soo Cho;Charles Eigenbrot;Kathryn M. Ferguson

  • EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization

    Kathryn M. Ferguson;Mitchell B. Berger;Jeannine M. Mendrola;Hyun Soo Cho

  • Signal-dependent membrane targeting by pleckstrin homology (PH) domains

    Mark A. Lemmon;Kathryn M. Ferguson

  • Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.

    T. Spivak-Kroizman;M.A. Lemmon;I. Dikic;J.E. Ladbury

  • Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

    Kathryn M. Ferguson;Mark A. Lemmon;Joseph Schlessinger;Paul B. Sigler

  • Phosphoinositide Recognition Domains

    Mark A. Lemmon

  • Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting

    M. Falasca;S.K. Logan;V.P. Lehto;G. Baccante

  • Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

    Mark A. Lemmon;Kathryn M. Ferguson;Ronan O'Brien;Paul B. Sigler

  • Regulation of signal transduction and signal diversity by receptor oligomerization.

    Mark A. Lemmon;Joseph Schlessinger

  • Sequence specificity in the dimerization of transmembrane alpha-helices.

    Mark A. Lemmon;John M. Flanagan;Herbert R. Treutlein;Jian Zhang

  • Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

    Joseph Schlessinger;Irit Lax;Mark Lemmon

  • Glycophorin A dimerization is driven by specific interactions between transmembrane alpha helices

    M.A. Lemmon;J.M. Flanagan;J.F. Hunt;B.D. Adair

  • PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

    Mark A Lemmon;Kathryn M Ferguson;Joseph Schlessinger

  • Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

    Jennifer M. Kavran;Daryl E. Klein;Anthony Lee;Marco Falasca

  • ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

    Fumin Shi;Shannon E. Telesco;Yingting Liu;Ravi Radhakrishnan

  • Two EGF molecules contribute additively to stabilization of the EGFR dimer

    Mark A. Lemmon;Zimei Bu;John Edward Simon Durham Ladbury;Min Zhou;Min Zhou

  • The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

    Mark A. Lemmon;Joseph Schlessinger;Kathryn M. Ferguson

  • SH2 and PTB domains in tyrosine kinase signaling

    Joseph Schlessinger;Mark A. Lemmon

Frequent Co-Authors

Joseph Schlessinger
Joseph Schlessinger Yale University
Yael P. Mosse
Yael P. Mosse Children's Hospital of Philadelphia
Donald M. Engelman
Donald M. Engelman Yale University
Irit Lax
Irit Lax Yale University
John E. Ladbury
John E. Ladbury University of Leeds
Edward Y. Skolnik
Edward Y. Skolnik New York University
Axel T. Brunger
Axel T. Brunger Stanford University
Jun Yu
Jun Yu Chinese University of Hong Kong
Michael S. Marks
Michael S. Marks Children's Hospital of Philadelphia
Graça Raposo
Graça Raposo Institut Curie

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