World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
125
Citations
85520
World Ranking
499
National Ranking
316

Research.com Recognitions

  • 2005 - Member of the National Academy of Sciences
  • 2003 - Gregori Aminoff Prize, Royal Swedish Academy of Sciences for his development of refinement techniques for macromolecules". Jones: "for his pioneering development of methods to interpret electron density maps and to build models of biological macromolecules with the aid of computer graphics

Overview

Axel T. Brunger is affiliated with Stanford University in the United States and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields including Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience, Physiology, and Infectious Diseases.

The scientist's main topics of work focus on areas such as:

  • Cellular transport and secretion
  • Lipid Membrane Structure and Behavior
  • Neuroscience and Neuropharmacology Research
  • RNA and protein synthesis mechanisms
  • SARS-CoV-2 and COVID-19 Research
  • Retinal Development and Disorders
  • Advanced Electron Microscopy Techniques and Applications

Axel T. Brunger has authored or co-authored papers published in a variety of venues. Among frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Biophysical Journal
  • Biopolymers
  • Nature

Several recent papers credited to or closely associated with their research include:

  • "The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines" (2021), Critical Reviews in Biochemistry and Molecular Biology
  • "The protein-folding problem: Not yet solved" (2022), Science
  • "Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies" (2020), Neuron
  • "Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides" (2022), Nature
  • "Prefused lysosomes cluster on autophagosomes regulated by VAMP8" (2021), Cell Death and Disease

The scientist has collaborated frequently with several co-authors, including:

  • Luis Esquivies
  • Richard A. Pfuetzner
  • Jeremy Leitz
  • Chuchu Wang
  • K. Ian White

Axel T. Brunger has been recognized with awards such as:

  • Member of the National Academy of Sciences (2005)
  • Gregori Aminoff Prize, Royal Swedish Academy of Sciences (2003) - awarded for contributions to the development of refinement techniques and methods for interpreting electron density maps to build models of biological macromolecules using computer graphics

Best Publications

  • Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

    A.T. Brünger;A.T. Brünger;P.D. Adams;G.M. Clore;W.L. DeLano

  • X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

    Axel T. Brünger

  • Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.

    Axel T. Brünger

  • Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

    Sutton Rb;Fasshauer D;Jahn R;Brunger At

  • Crystallographic R Factor Refinement by Molecular Dynamics

    Axel T. Brünger;John Kuriyan;Martin Karplus

  • Version 1.2 of the Crystallography and NMR system

    Axel T Brunger

  • Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

    Michael V. Milburn;Liang Tong;Abraham M. deVos;Axel Brünger

  • Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

    D Fasshauer;R B Sutton;A T Brunger;R Jahn

  • Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2.

    Michael Nilges;Angela M. Gronenborn;Axel T. Brünger;G. Marius Clore

  • Assessment of Phase Accuracy by Cross Validation: the Free R Value. Methods and Applications

    A. T. Brünger

  • Stochastic boundary conditions for molecular dynamics simulations of ST2 water

    Axel Brünger;Charles L. Brooks;Martin Karplus

  • Polar hydrogen positions in proteins: empirical energy placement and neutron diffraction comparison.

    Axel T. Brünger;Martin Karplus

  • Crystallographic refinement by simulated annealing

    A. T. Brünger

  • ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

    Jiajie Diao;Rong Liu;Yueguang Rong;Minglei Zhao

  • Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

    Daniel M Pinkas;Pavel Strop;Axel T Brunger;Chaitan Khosla

  • Torsion angle dynamics: reduced variable conformational sampling enhances crystallographic structure refinement

    Luke M. Rice;Axel T. BrüNger

  • A New Generation of Crystallographic Validation Tools for the Protein Data Bank

    Randy J. Read;Paul D. Adams;W. Bryan Arendall;Axel T. Brunger

  • Extension of molecular replacement: a new search strategy based on Patterson correlation refinement

    A. T. Brünger

  • Model bias in macromolecular crystal structures

    A. Hodel;Sung-Hou Kim;A. T. Brünger

  • Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

    Jian-Sheng Jiang;Axel T. Brünger

Frequent Co-Authors

Paul D. Adams
Paul D. Adams Lawrence Berkeley National Laboratory
William I. Weis
William I. Weis Stanford University
Thomas C. Südhof
Thomas C. Südhof Stanford University
Martin Karplus
Martin Karplus Harvard University
Steven Chu
Steven Chu Stanford University
Donald M. Engelman
Donald M. Engelman Yale University
Randy J. Read
Randy J. Read University of Cambridge
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Mark A. Lemmon
Mark A. Lemmon Yale University
Thomas C. Terwilliger
Thomas C. Terwilliger Los Alamos National Laboratory

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