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Chemistry

D-Index
76
Citations
94336
World Ranking
4155
National Ranking
1310

Research.com Recognitions

  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Thomas C. Terwilliger is affiliated with Los Alamos National Laboratory in the United States. Their research primarily spans fields including Biochemistry, Genetics and Molecular Biology, and Materials Science, with notable subfields in Molecular Biology, Materials Chemistry, and Structural Biology.

Their work frequently addresses themes connected to Enzyme Structure and Function, Advanced Electron Microscopy Techniques and Applications, Protein Structure and Dynamics, RNA and protein synthesis mechanisms, as well as Bacteriophages and microbial interactions and Mass Spectrometry Techniques and Applications.

Terwilliger has contributed to several peer-reviewed papers in prominent scientific journals. Selected recent publications include:

  • Improvement of cryo-EM maps by density modification, 2020, Nature Methods
  • AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination, 2023, Nature Methods
  • Improved AlphaFold modeling with implicit experimental information, 2022, Nature Methods

Their coauthors include Paul D. Adams, Randy J. Read, Pavel V. Afonine, Airlie J. McCoy, and Billy K. Poon, illustrating sustained collaborative research efforts.

Terwilliger's publications appear most frequently in specialized venues such as bioRxiv (Cold Spring Harbor Laboratory), Acta Crystallographica Section D Structural Biology, Nature Methods, Zenodo (CERN European Organization for Nuclear Research), and Acta Crystallographica Section A Foundations and Advances.

Recognition in their professional career includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2000.

Best Publications

  • Phenix - a comprehensive python-based system for macromolecular structure solution

    Paul D Adams;Paul D Adams;Pavel Afonine;Gábor Bunkóczi;Vincent B Chen

  • Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

    D. Liebschner;P.V. Afonine;M.L. Baker;G. Bunkóczi

  • Towards automated crystallographic structure refinement with phenix.refine

    Pavel V. Afonine;Ralf W. Grosse-Kunstleve;Nathaniel Echols;Jeffrey J. Headd

  • PHENIX: building new software for automated crystallographic structure determination

    Paul D Adams;Ralf W Grosse-Kunstleve;Li Wei Hung;Thomas R Ioerger

  • Automated MAD and MIR structure solution

    Thomas C. Terwilliger;Joel Berendzen

  • Real-space refinement in PHENIX for cryo-EM and crystallography.

    Pavel V. Afonine;Pavel V. Afonine;Billy K. Poon;Randy J. Read;Oleg V. Sobolev

  • Engineering and characterization of a superfolder green fluorescent protein.

    Jean-Denis Pédelacq;Stéphanie Cabantous;Timothy Tran;Thomas C Terwilliger

  • Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard

    Thomas C Terwilliger;Ralf W Grosse-Kunstleve;Pavel V Afonine;Nigel W Moriarty

  • The helical hydrophobic moment: a measure of the amphiphilicity of a helix

    David Eisenberg;Robert M. Weiss;Thomas C. Terwilliger

  • Rapid protein-folding assay using green fluorescent protein.

    Geoffrey S. Waldo;Blake M. Standish;Joel Berendzen;Thomas C. Terwilliger

  • The hydrophobic moment detects periodicity in protein hydrophobicity

    David Eisenberg;Robert M. Weiss;Thomas C. Terwilliger

  • Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein

    Stéphanie Cabantous;Thomas C Terwilliger;Geoffrey S Waldo

  • The Phenix software for automated determination of macromolecular structures.

    Paul D. Adams;Pavel V. Afonine;Gábor Bunkóczi;Vincent B. Chen

  • Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard

    Thomas C Terwilliger;Paul D Adams;Randy J Read;Airlie J McCoy

  • Automated main-chain model building by template matching and iterative fragment extension.

    Thomas C. Terwilliger

  • SOLVE and RESOLVE: automated structure solution and density modification.

    Thomas C Terwilliger

  • Polder maps: improving OMIT maps by excluding bulk solvent.

    Dorothee Liebschner;Pavel V. Afonine;Nigel W. Moriarty;Billy K. Poon

  • The structure of melittin. II. Interpretation of the structure.

    T C Terwilliger;D Eisenberg

  • Automated Structure Solution with the PHENIX Suite

    Peter H. Zwart;Pavel V. Afonine;Ralf W. Grosse-Kunstleve;Li-Wei Hung

  • SOLVE and RESOLVE: automated structure solution, density modification and model building

    Thomas Terwilliger

  • Hydrophobic moments and protein structure

    David Eisenberg;Robert M. Weiss;Thomas C. Terwilliger;William Wilcox

  • The structure of melittin in the form I crystals and its implication for melittin's lytic and surface activities

    T.C. Terwilliger;L. Weissman;D. Eisenberg

  • Automated structure solution, density modification and model building

    Thomas C. Terwilliger

  • The structure of melittin. I. Structure determination and partial refinement.

    T C Terwilliger;D Eisenberg

Frequent Co-Authors

Paul D. Adams
Paul D. Adams Lawrence Berkeley National Laboratory
Pavel V. Afonine
Pavel V. Afonine Lawrence Berkeley National Laboratory
Randy J. Read
Randy J. Read University of Cambridge
Ralf W. Grosse-Kunstleve
Ralf W. Grosse-Kunstleve Lawrence Berkeley National Laboratory
David Eisenberg
David Eisenberg Harvard University
Jane S. Richardson
Jane S. Richardson Duke University
Frank DiMaio
Frank DiMaio University of Washington
David Baker
David Baker University of Washington
Axel T. Brunger
Axel T. Brunger Stanford University
James C. Sacchettini
James C. Sacchettini Texas A&M University

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