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Stephen C. Harrison

Stephen C. Harrison

Award Badge
Biology and Biochemistry
USA
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
151
Citations
88039
World Ranking
171
National Ranking
118

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2015 - Welch Award in Chemistry, Robert A. Welch Foundation
  • 2014 - Fellow of the Royal Society, United Kingdom
  • 2006 - Gregori Aminoff Prize, Royal Swedish Academy of Sciences for their remarkable contributions in virus crystallography
  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 1991 - Member of the National Academy of Sciences
  • 1990 - Louisa Gross Horwitz Prize, Columbia University
  • 1989 - Fellow of the American Academy of Arts and Sciences

Overview

Stephen C. Harrison is affiliated with Harvard University in the United States. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. Subfields of particular interest include Molecular Biology, Infectious Diseases, Epidemiology, Cell Biology, and Plant Science.

Their recent research papers cover diverse topics with notable publications such as:

  • Structure of a nascent membrane protein as it folds on the BAM complex, 2020, Nature
  • Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate, 2020, eLife
  • Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike, 2021, Cell
  • Structure of a rabies virus polymerase complex from electron cryo-microscopy, 2020, Proceedings of the National Academy of Sciences
  • Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth, 2020, Science

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Proceedings of the National Academy of Sciences, Nature, and ACS Infectious Diseases.

Key research topics include:

  • Microtubule and mitosis dynamics
  • Influenza virus research studies
  • RNA and protein synthesis mechanisms
  • Respiratory viral infections research
  • SARS-CoV-2 and COVID-19 research
  • Monoclonal and polyclonal antibodies research
  • Plant nutrient uptake and metabolism

Stephen C. Harrison has collaborated often with other researchers, including Simon Jenni, Garnett Kelsoe, Stephen M. Hinshaw, Masayuki Kuraoka, and Ian W. Windsor.

The scientist has received several awards over the years. These include:

  • Welch Award in Chemistry, Robert A. Welch Foundation, 2015
  • Fellow of the Royal Society, United Kingdom, 2014
  • Gregori Aminoff Prize, Royal Swedish Academy of Sciences, 2006, for contributions in virus crystallography
  • Fellow of the American Association for the Advancement of Science (AAAS), 2005
  • Paul Ehrlich and Ludwig Darmstaedter Prize, 2001
  • Member of the National Academy of Sciences, 1991
  • Louisa Gross Horwitz Prize, Columbia University, 1990
  • Fellow of the American Academy of Arts and Sciences, 1989

Best Publications

  • Viral membrane fusion

    Stephen C. Harrison

  • Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor

    Fang Li;Wenhui Li;Wenhui Li;Michael Farzan;Michael Farzan;Stephen C. Harrison;Stephen C. Harrison

  • Atomic structure of the ectodomain from HIV-1 gp41

    W. Weissenhorn;A. Dessen;S. C. Harrison;S. C. Harrison;J. J. Skehel

  • The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution

    Félix A. Rey;Franz X. Heinz;Christian Mandl;Christian Kunz

  • Three-dimensional structure of the tyrosine kinase c-Src

    Wenqing Xu;Stephen C. Harrison;Michael J. Eck

  • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.

    Huifang Huang;Rajiv Chopra;Gregory L. Verdine;Stephen C. Harrison

  • X-ray structure of a protein-conducting channel

    Bert van den Berg;William M. Clemons;Ian Collinson;Yorgo Modis

  • Structure of the dengue virus envelope protein after membrane fusion

    Yorgo Modis;Steven Ogata;David Clements;Stephen C. Harrison

  • The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

    Thomas E. Ellenberger;Christopher J. Brandl;Kevin Struhl;Stephen C. Harrison

  • A Ligand-Binding Pocket in the Dengue Virus Envelope Glycoprotein.

    Yorgo Modis;Steven Ogata;David Clements;Stephen C. Harrison

  • Structure and mechanism of DNA topoisomerase II

    James M. Berger;Steven J. Gamblin;Steven J. Gamblin;Stephen C. Harrison;James C. Wang

  • Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

    Zhou Songyang;Zhou Songyang;Kermit L. Carraway;Michael J. Eck;Stephen C. Harrison

  • Structure of an IkappaBalpha/NF-kappaB complex.

    Marc D. Jacobs;Stephen C. Harrison;Stephen C. Harrison

  • Crystal structures of c-Src reveal features of its autoinhibitory mechanism.

    Wenqing Xu;Amish Doshi;Ming Lei;Michael J Eck

  • Crystal structure of the heterodimeric bZIP transcription factor c-Fos–c-Jun bound to DNA

    J. N. M. Glover;S. C. Harrison

  • Structure of simian virus 40 at 3.8-Å resolution

    R. C. Liddington;R. C. Liddington;Y. Yan;Y. Yan;J. Moulai;J. Moulai;R. Sahli;R. Sahli

  • Tomato bushy stunt virus at 2.9 A resolution.

    S. C. Harrison;A. J. Olson;C. E. Schutt;C. E. Schutt;F. K. Winkler;F. K. Winkler

  • DNA recognition by GAL4: structure of a protein-DNA complex

    Ronen Marmorstein;Michael Carey;Michael Carey;Mark Ptashne;Stephen C. Harrison;Stephen C. Harrison

  • A structural taxonomy of DNA-binding domains.

    Stephen C. Harrison

  • Lipid-protein interactions in double-layered two-dimensional AQP0 crystals

    Tamir Gonen;Yifan Cheng;Piotr Sliz;Piotr Sliz;Yoko Hiroaki

Frequent Co-Authors

Aaron G. Schmidt
Aaron G. Schmidt Ragon Institute of MGH, MIT and Harvard
Nikolaus Grigorieff
Nikolaus Grigorieff Howard Hughes Medical Institute
Tomas Kirchhausen
Tomas Kirchhausen Boston Children's Hospital
Don C. Wiley
Don C. Wiley Harvard University
Bing Chen
Bing Chen Harvard University
Philip R. Dormitzer
Philip R. Dormitzer Pfizer (United States)
Barton F. Haynes
Barton F. Haynes Duke University
Thomas B. Kepler
Thomas B. Kepler Boston University
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
Michael J. Eck
Michael J. Eck Harvard University

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