World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
30068
World Ranking
4226
National Ranking
2069

Overview

Nikolaus Grigorieff is affiliated with the Howard Hughes Medical Institute in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions to subfields including Molecular Biology, Structural Biology, Surfaces, Coatings and Films, Radiation, and Electrical and Electronic Engineering.

The scientist has published extensively in topics related to Advanced Electron Microscopy Techniques and Applications, Electron and X-Ray Spectroscopy Techniques, RNA and protein synthesis mechanisms, Advanced X-ray Imaging Techniques, Integrated Circuits and Semiconductor Failure Analysis, RNA modifications and cancer, and Protein Structure and Dynamics.

Grigorieff's frequent co-authors include Johannes Elferich, Bronwyn A. Lucas, Pilar Cossio, Timothy Grant, and Lingli Kong.

They have contributed multiple articles to the following publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Biophysical Journal
  • EMPIAR dataset
  • Proceedings of the National Academy of Sciences

Selected recent papers include:

  • Locating macromolecular assemblies in cells by 2D template matching with cisTEM, 2021, eLife
  • Structure and assembly of calcium homeostasis modulator proteins, 2020, Nature Structural & Molecular Biology
  • Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor, 2020, Cell Reports
  • Quantification of gallium cryo-FIB milling damage in biological lamellae, 2023, Proceedings of the National Academy of Sciences
  • mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding, 2020, eLife

Best Publications

  • CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

    Alexis Rohou;Nikolaus Grigorieff

  • Accurate determination of local defocus and specimen tilt in electron microscopy

    Joseph A. Mindell;Nikolaus Grigorieff

  • A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

    Susan Lynne McGovern;Emilia Caselli;Emilia Caselli;Nikolaus Grigorieff;Brian K. Shoichet

  • Electron-crystallographic refinement of the structure of bacteriorhodopsin.

    N. Grigorieff;N. Grigorieff;T.A. Ceska;T.A. Ceska;K.H. Downing;K.H. Downing;J.M. Baldwin;J.M. Baldwin

  • cisTEM, user-friendly software for single-particle image processing

    Timothy Grant;Alexis Rohou;Nikolaus Grigorieff

  • Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

    Timothy Grant;Nikolaus Grigorieff

  • Molecular model for a complete clathrin lattice from electron cryomicroscopy

    Alexander Fotin;Yifan Cheng;Piotr Sliz;Nikolaus Grigorieff

  • A primer to single-particle cryo-electron microscopy.

    Yifan Cheng;Nikolaus Grigorieff;Pawel A. Penczek;Thomas Walz

  • FREALIGN: high-resolution refinement of single particle structures.

    Nikolaus Grigorieff

  • Outcome of the First Electron Microscopy Validation Task Force Meeting

    Richard Henderson;Andrej Sali;Matthew L. Baker;Bridget Carragher

  • Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

    Melissa S Jurica;Lawrence J Licklider;Steven R Gygi;Nikolaus Grigorieff

  • Beam-induced motion of vitrified specimen on holey carbon film.

    Axel F. Brilot;James Z. Chen;James Z. Chen;Anchi Cheng;Junhua Pan

  • Three-dimensional structure of bovine NADH:ubiquinone oxidoreductase (complex I) at 22 å in ice

    N Grigorieff

  • Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.

    Xing Zhang;Ethan Settembre;Chen Xu;Philip R. Dormitzer

  • The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

    Gregory M. Alushin;Vincent H. Ramey;Sebastiano Pasqualato;David A. Ball

  • Atomic model of an infectious rotavirus particle.

    Ethan C Settembre;James Z Chen;Philip R Dormitzer;Nikolaus Grigorieff

  • Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

    Marcus Fändrich;Jessica Meinhardt;Nikolaus Grigorieff

  • Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils

    Jessica Meinhardt;Carsten Sachse;Carsten Sachse;Peter Hortschansky;Nikolaus Grigorieff

  • Movies of Ice-Embedded Particles Enhance Resolution in Electron Cryo-Microscopy

    Melody G. Campbell;Anchi Cheng;Axel F. Brilot;Arne Moeller

  • Comparison of Alzheimer Aβ(1–40) and Aβ(1–42) amyloid fibrils reveals similar protofilament structures

    Matthias Schmidt;Carsten Sachse;Walter Richter;Chen Xu

Frequent Co-Authors

Stephen C. Harrison
Stephen C. Harrison Harvard University
Marcus Fändrich
Marcus Fändrich University of Ulm
Thomas Walz
Thomas Walz Rockefeller University
Yifan Cheng
Yifan Cheng University of California, San Francisco
Philip R. Dormitzer
Philip R. Dormitzer Pfizer (United States)
John L. Rubinstein
John L. Rubinstein University of Toronto
Bruce L. Goode
Bruce L. Goode Brandeis University
Tomas Kirchhausen
Tomas Kirchhausen Boston Children's Hospital
Stephen J. Tucker
Stephen J. Tucker University of Oxford
Sean P. J. Whelan
Sean P. J. Whelan Washington University in St. Louis

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