World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
80
Citations
31565
World Ranking
1136
National Ranking
515

Research.com Recognitions

  • 2006 - Hellman Fellow
  • 2005 - Hellman Fellow

Overview

Sean P. J. Whelan is affiliated with Washington University in St. Louis in the United States. Their research primarily falls within the field of Medicine, with a focus on Infectious Diseases. Additional areas of study include Animal Science and Zoology, Immunology, Genetics, and Molecular Biology.

The scientist has contributed extensively to research on SARS-CoV-2 and COVID-19, including clinical research studies and investigations into viral infections and outbreaks. Other topics within their scope of work involve viral gastroenteritis research and epidemiology, animal virus infections, viral infections and vectors, and virus-based gene therapy research.

Sean P. J. Whelan's frequent co-authors include:

  • Zhuoming Liu
  • Paul W. Rothlauf
  • Michael Diamond
  • Louis-Marie Bloyet
  • James Brett Case

Their works have been published in several prominent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature
  • mBio
  • Cell Host & Microbe

Among recent papers authored or co-authored by Sean P. J. Whelan are:

  • Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus, 2020, Cell
  • Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition, 2020, Cell Host & Microbe
  • TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes, 2020, Science Immunology
  • N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2, 2021, Cell
  • Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization, 2021, Cell Host & Microbe

Sean P. J. Whelan was awarded the Hellman Fellow distinction in both 2005 and 2006.

Best Publications

  • Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.

    Bette Korber;Will M. Fischer;Sandrasegaram Gnanakaran;Hyejin Yoon

  • Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

    Jan E Carette;Jan E Carette;Matthijs Raaben;Anthony C. Wong;Andrew S. Herbert

  • Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.

    Allison J. Greaney;Allison J. Greaney;Tyler N. Starr;Pavlo Gilchuk;Seth J. Zost

  • Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection

    Kartik Chandran;Nancy J. Sullivan;Ute Felbor;Sean P. Whelan

  • TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.

    Ruochen Zang;Ruochen Zang;Maria Florencia Gomez Castro;Broc T. McCune;Qiru Zeng

  • N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2.

    Matthew McCallum;Anna De Marco;Florian A. Lempp;M. Alejandra Tortorici;M. Alejandra Tortorici

  • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

    Tobias Junt;E. Ashley Moseman;Matteo Iannacone;Steffen Massberg

  • Peroxisomes are signaling platforms for antiviral innate immunity

    Evelyn Dixit;Steeve Boulant;Yijing Zhang;Amy S.Y. Lee

  • Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.

    Zhuoming Liu;Laura A. VanBlargan;Louis Marie Bloyet;Paul W. Rothlauf;Paul W. Rothlauf

  • Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones

    S. P. J. Whelan;L. A. Ball;J. N. Barr;G. T. W. Wertz

  • Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.

    Seth J. Zost;Pavlo Gilchuk;Rita E. Chen;James Brett Case

  • SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.

    Tyler N. Starr;Nadine Czudnochowski;Zhuoming Liu;Fabrizia Zatta

  • Germinal centre-driven maturation of B cell response to mRNA vaccination

    Unknown

  • Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.

    James Brett Case;Paul W Rothlauf;Rita E Chen;Zhuoming Liu

  • Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.

    David K. Cureton;Ramiro H. Massol;Ramiro H. Massol;Saveez Saffarian;Tomas L. Kirchhausen

  • Transcription and Replication of Nonsegmented Negative-Strand RNA Viruses

    S. P. J. Whelan;J. N. Barr;G. W. Wertz

  • Ebola virus entry requires the host-programmed recognition of an intracellular receptor

    Emily Happy Miller;Gregor Obernosterer;Matthijs Raaben;Andrew S Herbert

  • Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

    Matteo Iannacone;E. Ashley Moseman;Elena Tonti;Lidia Bosurgi

  • SARS-CoV-2 spreads through cell-to-cell transmission

    Unknown

  • Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

    Lucas T. Jae;Matthijs Raaben;Moniek Riemersma;Ellen van Beusekom

  • Lassa virus entry requires a trigger-induced receptor switch

    Lucas T. Jae;Matthijs Raaben;Andrew S. Herbert;Ana I. Kuehne

  • TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes

    Ruochen Zang;Ruochen Zang;Maria F.G. Castro;Broc T. McCune;Qiru Zeng

Frequent Co-Authors

Michael S. Diamond
Michael S. Diamond Washington University in St. Louis
Stephen C. Harrison
Stephen C. Harrison Harvard University
Kartik Chandran
Kartik Chandran Albert Einstein College of Medicine
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital
Jesse D. Bloom
Jesse D. Bloom Fred Hutchinson Cancer Research Center
Daved H. Fremont
Daved H. Fremont Washington University in St. Louis
John M. Dye
John M. Dye United States Army Medical Research Institute of Infectious Diseases
Davide Corti
Davide Corti Vir Biotechnology (Switzerland)
Nikolaus Grigorieff
Nikolaus Grigorieff Howard Hughes Medical Institute

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