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Stefan Pöhlmann

Stefan Pöhlmann

D-Index & Metrics

Microbiology

D-Index
91
Citations
64165
World Ranking
634
National Ranking
37

Overview

Stefan Pöhlmann is affiliated with the German Primate Center in Germany and focuses primarily on research in the field of Medicine, with significant contributions to Infectious Diseases, Immunology, Molecular Biology, Epidemiology, and Animal Science and Zoology. Their work encompasses various aspects of virus biology and immune responses, largely centered on SARS-CoV-2 and COVID-19 research.

The main topics covered in Pöhlmann's research include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • Animal Virus Infections Studies
  • Virus-based gene therapy research
  • Viral gastroenteritis research and epidemiology
  • Immunotherapy and Immune Responses

Recent notable publications by Pöhlmann include:

  • "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor," 2020, Cell
  • "A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells," 2020, Molecular Cell
  • "SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies," 2021, Cell
  • "The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic," 2021, Cell
  • "The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Pöhlmann frequently collaborates with several researchers, including:

  • Markus Hoffmann
  • Amy Kempf
  • Inga Nehlmeier
  • Georg M. N. Behrens
  • Sebastian Schulz

Their work is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Lancet Infectious Diseases
  • Viruses
  • Nature Communications
  • Cellular and Molecular Immunology

Stefan Pöhlmann's research contributes extensively to understanding the mechanisms of virus cell entry, immune escape by variants, and neutralization resistance, with a strong focus on SARS-CoV-2 and its variants. Their interdisciplinary approach spans molecular virology, immunology, and epidemiology, addressing both fundamental viral processes and clinical aspects of COVID-19.

Best Publications

  • SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

    Markus Hoffmann;Hannah Kleine-Weber;Simon Schroeder;Nadine Krüger

  • A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.

    Markus Hoffmann;Hannah Kleine-Weber;Stefan Pöhlmann

  • The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

    Unknown

  • Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

    Ilona Glowacka;Stephanie Bertram;Marcel A. Müller;Paul Allen

  • Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

    Heike Hofmann;Krzysztof Pyrc;Lia van der Hoek;Martina Geier

  • TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.

    Adeline Heurich;Heike Hofmann-Winkler;Stefanie Gierer;Thomas Liepold

  • SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.

    Markus Hoffmann;Markus Hoffmann;Prerna Arora;Prerna Arora;Rüdiger Groß;Alina Seidel

  • The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

    Markus Hoffmann;Hannah Kleine-Weber;Nadine Krueger;Marcel A Mueller

  • Diversity of receptors binding HIV on dendritic cell subsets

    Stuart G. Turville;Paul U. Cameron;Amanda Handley;George Lin

  • Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

    Daniel Wrapp;Dorien De Vlieger;Kizzmekia S. Corbett;Gretel M. Torres

  • Protease inhibitors targeting coronavirus and filovirus entry

    Yanchen Zhou;Punitha Vedantham;Kai Lu;Juliet Agudelo

  • A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

    Katsue Suzuki-Inoue;Gemma L J Fuller;Angel Garcia;Johannes A Eble

  • Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR

    Stefan Pöhlmann;Jie Zhang;Frédéric Baribaud;Zhiwei Chen

  • Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19.

    Markus Hoffmann;Simon Schroeder;Simon Schroeder;Hannah Kleine-Weber;Marcel A. Müller;Marcel A. Müller

  • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

    Jacqueline D. Reeves;Stephen A. Gallo;Navid Ahmad;John L. Miamidian

  • Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

    Ilona Glowacka;Stephanie Bertram;Petra Herzog;Susanne Pfefferle

  • DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus

    Andrea Marzi;Thomas Gramberg;Graham Simmons;Peggy Möller

  • Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.

    Graham Simmons;Pawel Zmora;Stefanie Gierer;Adeline Heurich

  • Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.

    Markus Hoffmann;Markus Hoffmann;Kirstin Mösbauer;Kirstin Mösbauer;Heike Hofmann-Winkler;Artur Kaul

  • The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

    Susanne Pfefferle;Julia Schöpf;Manfred Kögl;Caroline C. Friedel;Caroline C. Friedel

  • DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

    Graham Simmons;Jacqueline D. Reeves;Case C. Grogan;Luk H. Vandenberghe

  • DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.

    Stefan Pöhlmann;Elizabeth J. Soilleux;Frédéric Baribaud;George J. Leslie

Frequent Co-Authors

Robert W. Doms
Robert W. Doms Children's Hospital of Philadelphia
Christian Drosten
Christian Drosten Charité - University Medicine Berlin
Frank Kirchhoff
Frank Kirchhoff University of Ulm
Andrea Marzi
Andrea Marzi National Institutes of Health
Jan Münch
Jan Münch University of Ulm
Marcel A. Müller
Marcel A. Müller Charité - University Medicine Berlin
Stephan Becker
Stephan Becker Philipp University of Marburg
Klaus Schughart
Klaus Schughart Helmholtz Centre for Infection Research
Friedemann Weber
Friedemann Weber University of Giessen
Erich Gulbins
Erich Gulbins University of Duisburg-Essen

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